Protein Alignment ems and Cdx1

DIOPT Version :10

• Sequence 1: NP_731868.1
• Gene: ems / 41697
• FlyBaseID: FBgn0000576
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: NP_034010.3
• Gene: Cdx1 / 12590
• MGIID: 88360
• Length: 268
• Species: Mus musculus
• Alignment Length: 236
• Identity: 71/236 - (30%)
• Similarity: 91/236 - (38%)
• Gaps: 50/236 - (21%)

  Fly   240 PNYPKPAMMHPGGAGPMMMPGMPPAGLVRPFPMGPGGPPMPQGQPGLPDIKALPPYINAPPELPP 304
            |.||.||.....|.||   |...|          ||..|.|   |..||.... .::...|..||
Mouse    12 PVYPGPARPSSLGLGP---PTYAP----------PGPAPAP---PQYPDFAGY-THVEPAPAPPP 59

  Fly   305 QHNPHLIAAAQF-----QMAAALQAGHVLGPAAAAAAAAGLPPH----AAQFMPNPGMARDSYQL 360
            ..      ||.|     ..|||...|.....|:.|..|.|.||.    .|...|.||:...|...
Mouse    60 TW------AAPFPAPKDDWAAAYGPGPTASAASPAPLAFGPPPDFSPVPAPPGPGPGILAQSLGA 118

  Fly   361 YPWLLSRHGRIFPHRFPGSFL-----------VPPFRKPKRIRTAFSPSQLLKLEHAFESNQYVV 414
             |...|..|.  |.|.|..::           ....|...:.|..::..|.|:||..|..::|:.
Mouse   119 -PGAPSSPGA--PRRTPYEWMRRSVAAAGGGGSGKTRTKDKYRVVYTDHQRLELEKEFHYSRYIT 180

  Fly   415 GAERKALAQNLNLSETQVKVWFQNRRTK----HKRMQQEDE 451
            ...:..||.||.|:|.|||:||||||.|    :|:.||:.:
Mouse   181 IRRKSELAANLGLTERQVKIWFQNRRAKERKVNKKKQQQQQ 221

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ems	NP_731868.1	Homeodomain	389..445	CDD:459649	23/59 (39%)
Cdx1	NP_034010.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..152		44/165 (27%)
		Caudal_act	13..140	CDD:461413	43/152 (28%)
		Homeodomain	156..211	CDD:459649	23/54 (43%)
		Interaction with DNA. /evidence=ECO:0000250|UniProtKB:P47902	157..178		6/20 (30%)
		Interaction with 5-mCpG DNA. /evidence=ECO:0000250|UniProtKB:P47902	196..207		8/10 (80%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	209..268		3/13 (23%)