Protein Alignment ems and CDX1

DIOPT Version :10

• Sequence 1: NP_731868.1
• Gene: ems / 41697
• FlyBaseID: FBgn0000576
• Length: 494
• Species: Drosophila melanogaster
• Sequence 2: NP_001795.2
• Gene: CDX1 / 1044
• HGNCID: 1805
• Length: 265
• Species: Homo sapiens
• Alignment Length: 260
• Identity: 70/260 - (26%)
• Similarity: 94/260 - (36%)
• Gaps: 98/260 - (37%)

  Fly   240 PNYPKPAMMHPGGAGPMMMPGMPPAGLVRPFPMGPG----GPPMPQGQPGLPDIKALPPYINAPP 300
            |.||.||                     ||..:|.|    |||.|            ||   |||
Human    12 PVYPGPA---------------------RPASLGLGPQAYGPPAP------------PP---APP 40

  Fly   301 ELP---------PQHNPHLIAAAQF-----QMAAALQAGHVLGPAAAAAAAAGLPPHAAQF--MP 349
            :.|         |...|.....|.|     ..|||...|.....|:.|:.|.|.||..:..  .|
Human    41 QYPDFSSYSHVEPAPAPPTAWGAPFPAPKDDWAAAYGPGPAAPAASPASLAFGPPPDFSPVPAPP 105

  Fly   350 NPGMARDSYQLYPWLLSRHGRIFPHRFPGSFLVPPFRKP------------------------KR 390
            .||         |.||::     |...||:...|..::|                        .:
Human   106 GPG---------PGLLAQ-----PLGGPGTPSSPGAQRPTPYEWMRRSVAAGGGGGSGKTRTKDK 156

  Fly   391 IRTAFSPSQLLKLEHAFESNQYVVGAERKALAQNLNLSETQVKVWFQNRRTK----HKRMQQEDE 451
            .|..::..|.|:||..|..::|:....:..||.||.|:|.|||:||||||.|    :|:.||:.:
Human   157 YRVVYTDHQRLELEKEFHYSRYITIRRKSELAANLGLTERQVKIWFQNRRAKERKVNKKKQQQQQ 221

  Fly   452  451
            Human   222  221

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ems	NP_731868.1	Homeodomain	389..445	CDD:459649	23/59 (39%)
CDX1	NP_001795.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	9..153		44/190 (23%)
		Caudal_act	13..142	CDD:461413	43/178 (24%)
		Homeodomain	156..211	CDD:459649	23/54 (43%)
		Interaction with DNA. /evidence=ECO:0000305|PubMed:28473536	157..178		6/20 (30%)
		Interaction with 5-mCpG DNA. /evidence=ECO:0000305|PubMed:28473536	196..207		8/10 (80%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	207..265		4/15 (27%)