DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nsf2 and TRIP13

DIOPT Version :9

Sequence 1:	NP_001287318.1	Gene:	Nsf2 / 41694	FlyBaseID:	FBgn0266464	Length:	752	Species:	Drosophila melanogaster
Sequence 2:	NP_004228.1	Gene:	TRIP13 / 9319	HGNCID:	12307	Length:	432	Species:	Homo sapiens

Alignment Length:	393	Identity:	83/393 - (21%)
Similarity:	157/393 - (39%)	Gaps:	75/393 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   148 DKKFLGLAVKTLEAVDPR-TVGDSLPKTRNVRFGRILGNTVVQFEKAENSVLNLQGRSKGKIVRQ 211
            |:.||...|:::..:|.. .|.||.|...:   ...:...:.|..:...|..||:..::..|...
Human    62 DEPFLTRNVQSVSIIDTELKVKDSQPIDLS---ACTVALHIFQLNEDGPSSENLEEETENIIAAN 123

  Fly   212 SIINPDWDFGKMGIGGL------DKEFNA-IFRRAFASRVFPPELVEQLGIKHVKGILLYGPPGT 269
            ..:.|..:|     .||      |.|..: :......:.:|..:.|....|...:.:||:|||||
Human   124 HWVLPAAEF-----HGLWDSLVYDVEVKSHLLDYVMTTLLFSDKNVNSNLITWNRVVLLHGPPGT 183

  Fly   270 GKTLMARQIGTMLNAR--------EPKIVNGPQILDKYVGESEANIRRLFAEAEEEEKRLGPNSG 326
            |||.:.:.:...|..|        :...:|...:..|:..||...:.::|.:.::   .:.....
Human   184 GKTSLCKALAQKLTIRLSSRYRYGQLIEINSHSLFSKWFSESGKLVTKMFQKIQD---LIDDKDA 245

  Fly   327 LHIIIFDEIDAICKARGSVAGNSGVHDT--VVNQLLAKIDGVEQLNNILVIGMTNRRDMIDEALL 389
            |..::.||::::..||.:....:...|.  |||.:|.:||.:::.:|::::..:|..:.||.|.:
Human   246 LVFVLIDEVESLTAARNACRAGTEPSDAIRVVNAVLTQIDQIKRHSNVVILTTSNITEKIDVAFV 310

  Fly   390 RPGRLEVQMEISLPNEQG--------------------RVQILNIHTKRMRDFNKIASDVDN--- 431
              .|.:::..|..|:...                    |.|:|.:....|..|  |.::|..
Human   311 --DRADIKQYIGPPSAAAIFKIYLSCLEELMKCQIIYPRQQLLTLRELEMIGF--IENNVSKLSL 371

  Fly   432 --NEIAAKTKNFSGAELEGLVRAAQSTAMNRLIKADSKVHVDPEAMEKLRVTRADFLHALDNDIK 494
              |:|:.|::..||..|..|...|.:.    .::|.:             ||...||.||...:.
Human   372 LLNDISRKSEGLSGRVLRKLPFLAHAL----YVQAPT-------------VTIEGFLQALSLAVD 419

  Fly   495 PAF 497
            ..|
Human   420 KQF 422

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nsf2	NP_001287318.1	CDC48_N	9..89	CDD:215012
		CDC48_2	117..>170	CDD:215011	6/22 (27%)
		AAA	259..404	CDD:214640	36/154 (23%)
		AAA	261..402	CDD:278434	36/150 (24%)
		AAA	543..674	CDD:214640
		P-loop_NTPase	544..>613	CDD:304359
TRIP13	NP_004228.1	SpoVK	<136..360	CDD:223540	46/228 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.900