DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nsf2 and SAP1

DIOPT Version :9

Sequence 1:	NP_001287318.1	Gene:	Nsf2 / 41694	FlyBaseID:	FBgn0266464	Length:	752	Species:	Drosophila melanogaster
Sequence 2:	NP_010966.1	Gene:	SAP1 / 856771	SGDID:	S000000849	Length:	897	Species:	Saccharomyces cerevisiae

Alignment Length:	343	Identity:	94/343 - (27%)
Similarity:	157/343 - (45%)	Gaps:	73/343 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   191 EKAENSVL-NLQG---RSKGKIVRQSIINPD---WDFGKMGIGGLDKEFNAIFRRAFASRVFPPE 248
            |..|:.:: :|||   ::..:|..:.:::.|   ||    .|.||:....:: :.|.......|:
Yeast   570 EILEDEIIDSLQGVDRQAAKQIFAEIVVHGDEVHWD----DIAGLESAKYSL-KEAVVYPFLRPD 629

  Fly   249 LVEQLGIKH-VKGILLYGPPGTGKTLMARQIGTMLNAREPKIVNGPQILDKYVGESEANIRRLFA 312
            |..  |::. |:|:||:||||||||::||.:.|..::....| :...:..||:||||..:|.|||
Yeast   630 LFR--GLREPVRGMLLFGPPGTGKTMLARAVATESHSTFFSI-SASSLTSKYLGESEKLVRALFA 691

  Fly   313 EAEEEEKRLGPNSGLHIIIFDEIDAICKAR----------------------------GSVAGNS 349
            .|    |:|.|:    ||..||||:|..:|                            ||...|:
Yeast   692 IA----KKLSPS----IIFVDEIDSIMGSRNNENENESSRRIKNEFLVQWSSLSSAAAGSNKSNT 748

  Fly   350 GVHDTVVNQLLAKIDGVEQLNNILVIGMTNRRDMIDEALLRPGRLEVQMEISLPNEQGRVQILNI 414
            ...||         :|.|....:||:..||....||||..|  |...:..|.||.:|.|    ::
Yeast   749 NNSDT---------NGDEDDTRVLVLAATNLPWSIDEAARR--RFVRRQYIPLPEDQTR----HV 798

  Fly   415 HTKRMRDFNK-IASDVDNNEIAAKTKNFSGAELEGLVRAAQSTAMNRLIKADSKVHVDPEAMEKL 478
            ..|::....| ..::.|.:|:...|:.:||:::..|.:.|....:..|  .|..:..:.|.:..:
Yeast   799 QFKKLLSHQKHTLTESDFDELVKITEGYSGSDITSLAKDAAMGPLRDL--GDKLLETEREMIRPI 861

  Fly   479 RVTRADFLHALDNDIKPA 496
            .:  .||.::|.. |||:
Yeast   862 GL--VDFKNSLVY-IKPS 876

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nsf2	NP_001287318.1	CDC48_N	9..89	CDD:215012
		CDC48_2	117..>170	CDD:215011
		AAA	259..404	CDD:214640	56/172 (33%)
		AAA	261..402	CDD:278434	54/168 (32%)
		AAA	543..674	CDD:214640
		P-loop_NTPase	544..>613	CDD:304359
SAP1	NP_010966.1	Herpes_BLLF1	<353..543	CDD:282904
SAP1	NP_010966.1	SpoVK	<557..890	CDD:223540	94/343 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810