DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nsf2 and YTA6

DIOPT Version :9

Sequence 1:	NP_001287318.1	Gene:	Nsf2 / 41694	FlyBaseID:	FBgn0266464	Length:	752	Species:	Drosophila melanogaster
Sequence 2:	NP_015251.1	Gene:	YTA6 / 856031	SGDID:	S000005995	Length:	754	Species:	Saccharomyces cerevisiae

Alignment Length:	319	Identity:	94/319 - (29%)
Similarity:	155/319 - (48%)	Gaps:	50/319 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   192 KAENSVLNLQGRSKG---KIVRQSIINPD---WDFGKMGIGGLDKEFNAIFRRAFASRVFPPELV 250
            :.|:.:.::||..:.   :|:.:.::..:   |:    .|.||....|:: :.|.......|:|.
Yeast   438 RKEDILKSVQGVDRNACEQILNEILVTDEKVYWE----DIAGLRNAKNSL-KEAVVYPFLRPDLF 497

  Fly   251 EQLGIKH-VKGILLYGPPGTGKTLMARQIGTMLNAREPKIVNGPQILDKYVGESEANIRRLFAEA 314
            :  |::. |:|:||:||||||||::|:.:.|..|:.... |:...:|.||:||||..:|.||..|
Yeast   498 K--GLREPVRGMLLFGPPGTGKTMIAKAVATESNSTFFS-VSASSLLSKYLGESEKLVRALFYMA 559

  Fly   315 EEEEKRLGPNSGLHIIIFDEIDAICKARGSVAGNSGVHDTVVNQLLAKIDGV-------EQLNN- 371
                |:|.|:    ||..||||::..||......|.  ..:..:||.:...:       |..||
Yeast   560 ----KKLSPS----IIFIDEIDSMLTARSDNENESS--RRIKTELLIQWSSLSSATAQSEDRNNT 614

  Fly   372 ----ILVIGMTNRRDMIDEALLRPGRLEVQMEISLPNEQGRVQILNIHTKRMRDFNKIA-SDVDN 431
                :||:|.||....||:|..|  |...::.|.||:.:.|:    .|.||:....|.: .|:|.
Yeast   615 LDSRVLVLGATNLPWAIDDAARR--RFSRKLYIPLPDYETRL----YHLKRLMAKQKNSLQDLDY 673

  Fly   432 NEIAAKTKNFSGAELEGLVRAAQSTAMNRLIKADSKVHVDPEAMEKLR-VTRADFLHAL 489
            ..|...|:.|||::|..|.:.|....:..|  .|..:..|   .:|:| :...||.:||
Yeast   674 ELITEMTEGFSGSDLTSLAKEAAMEPIRDL--GDKLMFAD---FDKIRGIEIKDFQNAL 727

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nsf2	NP_001287318.1	CDC48_N	9..89	CDD:215012
		CDC48_2	117..>170	CDD:215011
		AAA	259..404	CDD:214640	55/156 (35%)
		AAA	261..402	CDD:278434	53/152 (35%)
		AAA	543..674	CDD:214640
		P-loop_NTPase	544..>613	CDD:304359
YTA6	NP_015251.1	SpoVK	201..747	CDD:223540	94/319 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810