DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nsf2 and MSP1

DIOPT Version :9

Sequence 1:	NP_001287318.1	Gene:	Nsf2 / 41694	FlyBaseID:	FBgn0266464	Length:	752	Species:	Drosophila melanogaster
Sequence 2:	NP_011542.3	Gene:	MSP1 / 852915	SGDID:	S000003260	Length:	362	Species:	Saccharomyces cerevisiae

Alignment Length:	300	Identity:	95/300 - (31%)
Similarity:	144/300 - (48%)	Gaps:	36/300 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   207 KIVRQSIINPD-WDFGKMGIGGLDKEFNAIFRRAFASRVFP---PELVEQLGIKHV-KGILLYGP 266
            :.:..||:.|| .:.....|||||...:.:..    |.::|   ||:.....:... .|:|||||
Yeast    74 RTILSSIVTPDEINITFQDIGGLDPLISDLHE----SVIYPLMMPEVYSNSPLLQAPSGVLLYGP 134

  Fly   267 PGTGKTLMARQIGTMLNAREPKIVNGPQILDKYVGESEANIRRLFAEAEEEEKRLGPNSGLHIII 331
            ||.|||::|:.:.....|....| ....|:||:.|||...:..:|:.|    .:|.|    .||.
Yeast   135 PGCGKTMLAKALAKESGANFISI-RMSSIMDKWYGESNKIVDAMFSLA----NKLQP----CIIF 190

  Fly   332 FDEIDAICKARGSVAGNSGVHDTVVNQLLAKIDGVEQLNN--ILVIGMTNRRDMIDEALLRPGRL 394
            .||||:..:.|.|.  :..|..|:..:.:...||:  |||  :::||.|||.:.||:|.||  ||
Yeast   191 IDEIDSFLRERSST--DHEVTATLKAEFMTLWDGL--LNNGRVMIIGATNRINDIDDAFLR--RL 249

  Fly   395 EVQMEISLPNEQGRVQILNIHTKRMRDFNKIASDVDNNEIAAKTKNFSGAELEGLVRAAQSTAMN 459
            ..:..:|||....|.:||::   .::|......:.|...||..||.|||::|:.|.|.|...|..
Yeast   250 PKRFLVSLPGSDQRYKILSV---LLKDTKLDEDEFDLQLIADNTKGFSGSDLKELCREAALDAAK 311

  Fly   460 RLIK-----ADS-KVHVDPEAMEKLRVTRA-DFLHALDND 492
            ..||     .|| .:.|:..:..|:|..:. ||...|..|
Yeast   312 EYIKQKRQLIDSGTIDVNDTSSLKIRPLKTKDFTKKLRMD 351

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nsf2	NP_001287318.1	CDC48_N	9..89	CDD:215012
		CDC48_2	117..>170	CDD:215011
		AAA	259..404	CDD:214640	53/146 (36%)
		AAA	261..402	CDD:278434	50/142 (35%)
		AAA	543..674	CDD:214640
		P-loop_NTPase	544..>613	CDD:304359
MSP1	NP_011542.3	MDN1	<10..>164	CDD:227596	28/94 (30%)
		RecA-like_ATAD1	92..255	CDD:410928	60/181 (33%)
		AAA_lid_3	280..319	CDD:407720	15/38 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810