DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Nsf2 and SEC18

DIOPT Version :9

Sequence 1:NP_001287318.1 Gene:Nsf2 / 41694 FlyBaseID:FBgn0266464 Length:752 Species:Drosophila melanogaster
Sequence 2:NP_009636.3 Gene:SEC18 / 852372 SGDID:S000000284 Length:758 Species:Saccharomyces cerevisiae


Alignment Length:752 Identity:319/752 - (42%)
Similarity:482/752 - (64%) Gaps:39/752 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 KAHRMRAIKCPTDELSLTNKAIVNVSDFTEEVKYVDISPGPGLHYIFALEKISGPELPLGHVGFS 69
            :...::...||.:..:|.|.|.|:.:||...: |:.|.      .:|........::|.|.:||:
Yeast    25 RTRHLKVSNCPNNSYALANVAAVSPNDFPNNI-YIIID------NLFVFTTRHSNDIPPGTIGFN 82

  Fly    70 LVQRKWATLSINQEIDVRP---YRFDASADIITLVSFETDFLQKKTTTQEPYDSDEMAKEFLMQF 131
            ..||.|...|:||::..:.   :::......:..:..:..|..:.......:|.||:||:|:..:
Yeast    83 GNQRTWGGWSLNQDVQAKAFDLFKYSGKQSYLGSIDIDISFRARGKAVSTVFDQDELAKQFVRCY 147

  Fly   132 AGMPLTVGQTLVFQFKDKKFLGLAVKTLEAVDPRTVGDSLP--------KTRNVRFGRILGNTVV 188
            .....:..|.|:.:|:. .|..|.::.::|:|   :||..|        :|:    |.:...|.:
Yeast   148 ESQIFSPTQYLIMEFQG-HFFDLKIRNVQAID---LGDIEPTSAVATGIETK----GILTKQTQI 204

  Fly   189 QFEKAENSVLNLQGRSKGKIVRQSIINPDWDFGKMGIGGLDKEFNAIFRRAFASRVFPPELVEQL 253
            .|.|..:.::||:..:..:....::|.||:.|..:|:|||||||..|||||||||:|||.::|:|
Yeast   205 NFFKGRDGLVNLKSSNSLRPRSNAVIRPDFKFEDLGVGGLDKEFTKIFRRAFASRIFPPSVIEKL 269

  Fly   254 GIKHVKGILLYGPPGTGKTLMARQIGTMLNAREPKIVNGPQILDKYVGESEANIRRLFAEAEEEE 318
            ||.||||:||||||||||||:||:|||||||:||||||||:||.||||.||.|||.||.:||.|.
Yeast   270 GISHVKGLLLYGPPGTGKTLIARKIGTMLNAKEPKIVNGPEILSKYVGSSEENIRNLFKDAEAEY 334

  Fly   319 KRLGPNSGLHIIIFDEIDAICKARGSVAGNSGVHDTVVNQLLAKIDGVEQLNNILVIGMTNRRDM 383
            :..|..|.||||||||:|::.|.|||....:||.|.||||||||:|||:|||||||||||||:|:
Yeast   335 RAKGEESSLHIIIFDELDSVFKQRGSRGDGTGVGDNVVNQLLAKMDGVDQLNNILVIGMTNRKDL 399

  Fly   384 IDEALLRPGRLEVQMEISLPNEQGRVQILNIHTKRMRDFNKIASDVDNNEIAAKTKNFSGAELEG 448
            ||.|||||||.|||:||.||:|:||:||.:|.||:||:.|.::.||:..|:||.||||||||:||
Yeast   400 IDSALLRPGRFEVQVEIHLPDEKGRLQIFDIQTKKMRENNMMSDDVNLAELAALTKNFSGAEIEG 464

  Fly   449 LVRAAQSTAMNRLI---KADSKVHVDPEAMEKLRVTRADFLHALDNDIKPAFGAAQEMLENLLAR 510
            ||::|.|.|:|:.:   |..:|::.  :.:.||:|||.|||:|| ||:.||||.::|.|:..:..
Yeast   465 LVKSASSFAINKTVNIGKGATKLNT--KDIAKLKVTREDFLNAL-NDVTPAFGISEEDLKTCVEG 526

  Fly   511 GIINWGPPVTELLEDGMLSVQQAKATESSGLVSVLIEGAPNSGKSALAANLAQLSDFPFVKVCSP 575
            |::.:...|..:|::|...|:|.:.::.|.|||:||.|...|||:||||.:|..|.|||:::.||
Yeast   527 GMMLYSERVNSILKNGARYVRQVRESDKSRLVSLLIHGPAGSGKTALAAEIALKSGFPFIRLISP 591

  Fly   576 EDMVGFTESAKCLHIRKIFDDAYRSTLSCIVVDNVERLLDYGPIGPRYSNLTLQALLVLLKKQPP 640
            .::.|.:||||..:|...|.|||:|.|:.:|:|::|.|:|:.|||||:||..||.|.|.||::||
Yeast   592 NELSGMSESAKIAYIDNTFRDAYKSPLNILVIDSLETLVDWVPIGPRFSNNILQMLKVALKRKPP 656

  Fly   641 KGRKLLILCTSSRRDVLEEMEMLSAFTSVLHVSNLSTPENVLAVLDDSDLFSPEELQSIARKMAG 705
            :.|:|||:.|:|...||::|::||.|.:.:.|.|::..:.:..|:.:|:.........:..::: 
Yeast   657 QDRRLLIMTTTSAYSVLQQMDILSCFDNEIAVPNMTNLDELNNVMIESNFLDDAGRVKVINELS- 720

  Fly   706 KRLC----IGIKKLLALIDMIRQSE-PHQRVIKFLSK 737
             |.|    :||||.|..|:..|..| |...:::.:::
Yeast   721 -RSCPNFNVGIKKTLTNIETARHDEDPVNELVELMTQ 756

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nsf2NP_001287318.1 CDC48_N 9..89 CDD:215012 21/82 (26%)
CDC48_2 117..>170 CDD:215011 14/52 (27%)
AAA 259..404 CDD:214640 105/144 (73%)
AAA 261..402 CDD:278434 102/140 (73%)
AAA 543..674 CDD:214640 63/130 (48%)
P-loop_NTPase 544..>613 CDD:304359 32/68 (47%)
SEC18NP_009636.3 CDC48_N 29..98 CDD:215012 21/75 (28%)
CDC48_2 134..204 CDD:215011 19/77 (25%)
RecA-like_NSF-SEC18_r1-like 240..416 CDD:410912 128/175 (73%)
SpoVK 263..758 CDD:223540 251/499 (50%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C157343996
Domainoid 1 1.000 208 1.000 Domainoid score I519
eggNOG 1 0.900 - - E1_COG0464
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H4502
Inparanoid 1 1.050 595 1.000 Inparanoid score I135
Isobase 1 0.950 - 0 Normalized mean entropy S525
OMA 1 1.010 - - QHG52406
OrthoFinder 1 1.000 - - FOG0003053
OrthoInspector 1 1.000 - - otm46683
orthoMCL 1 0.900 - - OOG6_101440
Panther 1 1.100 - - LDO PTHR23078
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1308
SonicParanoid 1 1.000 - - X2410
TreeFam 1 0.960 - -
1615.740

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