Protein Alignment Nsf2 and SEC18

DIOPT Version :10

• Sequence 1: NP_788676.1
• Gene: Nsf2 / 41694
• FlyBaseID: FBgn0266464
• Length: 752
• Species: Drosophila melanogaster
• Sequence 2: NP_009636.3
• Gene: SEC18 / 852372
• SGDID: S000000284
• Length: 758
• Species: Saccharomyces cerevisiae
• Alignment Length: 752
• Identity: 319/752 - (42%)
• Similarity: 482/752 - (64%)
• Gaps: 39/752 - (5%)

  Fly     5 KAHRMRAIKCPTDELSLTNKAIVNVSDFTEEVKYVDISPGPGLHYIFALEKISGPELPLGHVGFS 69
            :...::...||.:..:|.|.|.|:.:||...: |:.|.      .:|........::|.|.:||:
Yeast    25 RTRHLKVSNCPNNSYALANVAAVSPNDFPNNI-YIIID------NLFVFTTRHSNDIPPGTIGFN 82

  Fly    70 LVQRKWATLSINQEIDVRP---YRFDASADIITLVSFETDFLQKKTTTQEPYDSDEMAKEFLMQF 131
            ..||.|...|:||::..:.   :::......:..:..:..|..:.......:|.||:||:|:..:
Yeast    83 GNQRTWGGWSLNQDVQAKAFDLFKYSGKQSYLGSIDIDISFRARGKAVSTVFDQDELAKQFVRCY 147

  Fly   132 AGMPLTVGQTLVFQFKDKKFLGLAVKTLEAVDPRTVGDSLP--------KTRNVRFGRILGNTVV 188
            .....:..|.|:.:|:. .|..|.::.::|:|   :||..|        :|:    |.:...|.:
Yeast   148 ESQIFSPTQYLIMEFQG-HFFDLKIRNVQAID---LGDIEPTSAVATGIETK----GILTKQTQI 204

  Fly   189 QFEKAENSVLNLQGRSKGKIVRQSIINPDWDFGKMGIGGLDKEFNAIFRRAFASRVFPPELVEQL 253
            .|.|..:.::||:..:..:....::|.||:.|..:|:|||||||..|||||||||:|||.::|:|
Yeast   205 NFFKGRDGLVNLKSSNSLRPRSNAVIRPDFKFEDLGVGGLDKEFTKIFRRAFASRIFPPSVIEKL 269

  Fly   254 GIKHVKGILLYGPPGTGKTLMARQIGTMLNAREPKIVNGPQILDKYVGESEANIRRLFAEAEEEE 318
            ||.||||:||||||||||||:||:|||||||:||||||||:||.||||.||.|||.||.:||.|.
Yeast   270 GISHVKGLLLYGPPGTGKTLIARKIGTMLNAKEPKIVNGPEILSKYVGSSEENIRNLFKDAEAEY 334

  Fly   319 KRLGPNSGLHIIIFDEIDAICKARGSVAGNSGVHDTVVNQLLAKIDGVEQLNNILVIGMTNRRDM 383
            :..|..|.||||||||:|::.|.|||....:||.|.||||||||:|||:|||||||||||||:|:
Yeast   335 RAKGEESSLHIIIFDELDSVFKQRGSRGDGTGVGDNVVNQLLAKMDGVDQLNNILVIGMTNRKDL 399

  Fly   384 IDEALLRPGRLEVQMEISLPNEQGRVQILNIHTKRMRDFNKIASDVDNNEIAAKTKNFSGAELEG 448
            ||.|||||||.|||:||.||:|:||:||.:|.||:||:.|.::.||:..|:||.||||||||:||
Yeast   400 IDSALLRPGRFEVQVEIHLPDEKGRLQIFDIQTKKMRENNMMSDDVNLAELAALTKNFSGAEIEG 464

  Fly   449 LVRAAQSTAMNRLI---KADSKVHVDPEAMEKLRVTRADFLHALDNDIKPAFGAAQEMLENLLAR 510
            ||::|.|.|:|:.:   |..:|::.  :.:.||:|||.|||:|| ||:.||||.::|.|:..:..
Yeast   465 LVKSASSFAINKTVNIGKGATKLNT--KDIAKLKVTREDFLNAL-NDVTPAFGISEEDLKTCVEG 526

  Fly   511 GIINWGPPVTELLEDGMLSVQQAKATESSGLVSVLIEGAPNSGKSALAANLAQLSDFPFVKVCSP 575
            |::.:...|..:|::|...|:|.:.::.|.|||:||.|...|||:||||.:|..|.|||:::.||
Yeast   527 GMMLYSERVNSILKNGARYVRQVRESDKSRLVSLLIHGPAGSGKTALAAEIALKSGFPFIRLISP 591

  Fly   576 EDMVGFTESAKCLHIRKIFDDAYRSTLSCIVVDNVERLLDYGPIGPRYSNLTLQALLVLLKKQPP 640
            .::.|.:||||..:|...|.|||:|.|:.:|:|::|.|:|:.|||||:||..||.|.|.||::||
Yeast   592 NELSGMSESAKIAYIDNTFRDAYKSPLNILVIDSLETLVDWVPIGPRFSNNILQMLKVALKRKPP 656

  Fly   641 KGRKLLILCTSSRRDVLEEMEMLSAFTSVLHVSNLSTPENVLAVLDDSDLFSPEELQSIARKMAG 705
            :.|:|||:.|:|...||::|::||.|.:.:.|.|::..:.:..|:.:|:.........:..:::
Yeast   657 QDRRLLIMTTTSAYSVLQQMDILSCFDNEIAVPNMTNLDELNNVMIESNFLDDAGRVKVINELS- 720

  Fly   706 KRLC----IGIKKLLALIDMIRQSE-PHQRVIKFLSK 737
             |.|    :||||.|..|:..|..| |...:::.:::
Yeast   721 -RSCPNFNVGIKKTLTNIETARHDEDPVNELVELMTQ 756

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nsf2	NP_788676.1	CDC48_N	9..89	CDD:215012	21/82 (26%)
		CDC48_2	117..>170	CDD:215011	14/52 (27%)
		RecA-like_NSF-SEC18_r1-like	224..400	CDD:410912	128/175 (73%)
		CDC48	<225..>611	CDD:273521	224/388 (58%)
SEC18	NP_009636.3	CDC48_N	29..98	CDD:215012	21/75 (28%)
		CDC48_2	134..204	CDD:215011	19/77 (25%)
		CDC48	<232..>629	CDD:273521	229/399 (57%)
		RecA-like_NSF-SEC18_r1-like	240..416	CDD:410912	128/175 (73%)