Protein Alignment Nsf2 and CDC48

DIOPT Version :10

• Sequence 1: NP_788676.1
• Gene: Nsf2 / 41694
• FlyBaseID: FBgn0266464
• Length: 752
• Species: Drosophila melanogaster
• Sequence 2: NP_010157.1
• Gene: CDC48 / 851431
• SGDID: S000002284
• Length: 835
• Species: Saccharomyces cerevisiae
• Alignment Length: 648
• Identity: 186/648 - (28%)
• Similarity: 285/648 - (43%)
• Gaps: 132/648 - (20%)

  Fly   159 LEAVDPRTVGDSLPKTRNVRFG-RILGNTVVQFEK------AENSVLNLQGRSKGKIVRQSIINP 216
            :||..|...||...    ||.| |.:...||..|.      |::::::.:|....:...::.:|
Yeast   150 VEAYRPVRKGDHFV----VRGGMRQVEFKVVDVEPEEYAVVAQDTIIHWEGEPINREDEENNMN- 209

  Fly   217 DWDFGKMGIGGLDKEFNAIFRRAFASRVFPPELVEQLGIKHVKGILLYGPPGTGKTLMARQIGTM 281
              :.|...|||..|:. |..|......:..|:|.:.:|||..:|:|:|||||||||||||.:
Yeast   210 --EVGYDDIGGCRKQM-AQIREMVELPLRHPQLFKAIGIKPPRGVLMYGPPGTGKTLMARAV--- 268

  Fly   282 LNAREPK----IVNGPQILDKYVGESEANIRRLFAEAEEEEKRLGPNSGLHIIIFDEIDAICKAR 342
              |.|..    ::|||:::.|..||||:|:|:.|.|||:....        ||..||||:|...|
Yeast   269 --ANETGAFFFLINGPEVMSKMAGESESNLRKAFEEAEKNAPA--------IIFIDEIDSIAPKR 323

  Fly   343 GSVAGNSGVHDTVVNQLLAKIDGVEQLNNILVIGMTNRRDMIDEALLRPGRLEVQMEISLPNEQG 407
            ...  |..|...||:|||..:||::..:|::||..|||.:.||.||.|.||.:.:::|.:|:..|
Yeast   324 DKT--NGEVERRVVSQLLTLMDGMKARSNVVVIAATNRPNSIDPALRRFGRFDREVDIGIPDATG 386

  Fly   408 RVQILNIHTKRMRDFNKIASDVDNNEIAAKTKNFSGAELEGLVRAAQSTAMNR------LIKADS 466
            |:::|.||||.|    |:|.|||...:||:|..:.||::..|...|   ||.:      ||..|.
Yeast   387 RLEVLRIHTKNM----KLADDVDLEALAAETHGYVGADIASLCSEA---AMQQIREKMDLIDLDE 444

  Fly   467 KVHVDPEAMEKLRVTRADFLHALDNDIKPAF---------------GAAQEMLENLLARGIINWG 516
            . .:|.|.::.|.||..:|..||.|....|.               |...|:.|.|
Yeast   445 D-EIDAEVLDSLGVTMDNFRFALGNSNPSALRETVVESVNVTWDDVGGLDEIKEEL--------- 499

  Fly   517 PPVTELLEDGMLSVQQAKATESSGLVSVLIEGAPNSGKSALAANLAQLSDFPFVKVCSPEDM--- 578
               .|.:|..:|...|......|....||..|.|.:||:.||..:|......|:.|..||.:
Yeast   500 ---KETVEYPVLHPDQYTKFGLSPSKGVLFYGPPGTGKTLLAKAVATEVSANFISVKGPELLSMW 561

  Fly   579 VGFTESAKCLHIRKIFDDAYRSTLSCIVVDNVERLL--------DYGPIGPRYSNLTLQALLVLL 635
            .|.:||    :||.|||.|..:..:.:.:|.::.:.        |.|....|..|..|..:..:.
Yeast   562 YGESES----NIRDIFDKARAAAPTVVFLDELDSIAKARGGSLGDAGGASDRVVNQLLTEMDGMN 622

  Fly   636 KKQPPKGRKLLILCTSSRRDVL-------------------EEMEMLSAFTSVLHVSNLSTPENV 681
            .|     :.:.::..::|.|.:                   :|...||...:.|..:.|.....:
Yeast   623 AK-----KNVFVIGATNRPDQIDPAILRPGRLDQLIYVPLPDENARLSILNAQLRKTPLEPGLEL 682

  Fly   682 LAVLDDSDLFSPEELQSIARKMAGKRLCIGIKKLLALIDMI---RQSEPHQRVIKFLSKMEEE 741
            .|:...:..||..:|..|.::.|          ..|:.|.|   ||.|..:.|     |:|.|
Yeast   683 TAIAKATQGFSGADLLYIVQRAA----------KYAIKDSIEAHRQHEAEKEV-----KVEGE 730

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nsf2	NP_788676.1	CDC48_N	9..89	CDD:215012
		CDC48_2	117..>170	CDD:215011	4/10 (40%)
		RecA-like_NSF-SEC18_r1-like	224..400	CDD:410912	72/179 (40%)
		CDC48	<225..>611	CDD:273521	141/413 (34%)
CDC48	NP_010157.1	CDC48	48..785	CDD:273521	186/648 (29%)