DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nsf2 and ATAD1

DIOPT Version :9

Sequence 1:	NP_001287318.1	Gene:	Nsf2 / 41694	FlyBaseID:	FBgn0266464	Length:	752	Species:	Drosophila melanogaster
Sequence 2:	NP_001308896.1	Gene:	ATAD1 / 84896	HGNCID:	25903	Length:	361	Species:	Homo sapiens

Alignment Length:	383	Identity:	95/383 - (24%)
Similarity:	163/383 - (42%)	Gaps:	98/383 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   159 LEAVDPRTVGDSLPKTRNVRFGRILGNTVVQFEKAENSVLNLQGRSKGKI------VRQSIINP- 216
            ::|:||         ||..:         |:.:|....::...|....|:      :...:::|
Human    38 VDAIDP---------TRKQK---------VEAQKQAEKLMKQIGVKNVKLSEYEMSIAAHLVDPL 84

  Fly   217 ----DWDFGKMGIGGLDK-------------EFNAIFRRAFASRVFPPELVEQLGIKHVKGILLY 264
                .|.    .|.|||.             :...:|..   ||:..|.          ||:|||
Human    85 NMHVTWS----DIAGLDDVITDLKDTVILPIKKKHLFEN---SRLLQPP----------KGVLLY 132

  Fly   265 GPPGTGKTLMARQIGTMLNAREP--KIVN-GPQIL-DKYVGESEANIRRLFAEAEEEEKRLGPNS 325
            ||||.||||:|:     ..|:|.  :.:| .|..| ||:.|||:.....:|:.|    .:|.|:
Human   133 GPPGCGKTLIAK-----ATAKEAGCRFINLQPSTLTDKWYGESQKLAAAVFSLA----IKLQPS- 187

  Fly   326 GLHIIIFDEIDAICKARGSVAGNSGVHDTVV---NQLLAKIDGVEQLNN--ILVIGMTNRRDMID 385
               ||..||||:..:.|     :|..|:...   .|.::..||::..::  ::|:|.|||...:|
Human   188 ---IIFIDEIDSFLRNR-----SSSDHEATAMMKAQFMSLWDGLDTDHSCQVIVMGATNRPQDLD 244

  Fly   386 EALLRPGRLEVQMEISLPNEQGRVQILNIHTKRMRDFNKIASDVDNNEIAAKTKNFSGAELEGLV 450
            .|::|  |:..:..|:.|..:.|..||.:..|.    ..:...||..|:|.:|..|||::|:.:.
Human   245 SAIMR--RMPTRFHINQPALKQREAILKLILKN----ENVDRHVDLLEVAQETDGFSGSDLKEMC 303

  Fly   451 RAAQSTAMNRLIKADSKVHVDPEAMEKLRVTRADFLHALDNDIKPAFGAAQEMLENLL 508
            |.|....:...:.:.|:...|.   :::|..:...||.....:|.:..||   .:|:|
Human   304 RDAALLCVREYVNSTSEESHDE---DEIRPVQQQDLHRAIEKMKKSKDAA---FQNVL 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nsf2	NP_001287318.1	CDC48_N	9..89	CDD:215012
		CDC48_2	117..>170	CDD:215011	3/10 (30%)
		AAA	259..404	CDD:214640	50/153 (33%)
		AAA	261..402	CDD:278434	48/149 (32%)
		AAA	543..674	CDD:214640
		P-loop_NTPase	544..>613	CDD:304359
ATAD1	NP_001308896.1	RecA-like_ATAD1	92..257	CDD:410928	57/197 (29%)
ATAD1	NP_001308896.1	AAA_lid_3	282..321	CDD:407720	12/38 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810