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Protein Alignment Nsf2 and AFG2B

DIOPT Version :10

Sequence 1:	NP_788676.1	Gene:	Nsf2 / 41694	FlyBaseID:	FBgn0266464	Length:	752	Species:	Drosophila melanogaster
Sequence 2:	NP_076968.2	Gene:	AFG2B / 79029	HGNCID:	28762	Length:	753	Species:	Homo sapiens

Alignment Length:	587	Identity:	158/587 - (26%)
Similarity:	250/587 - (42%)	Gaps:	136/587 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   225 IGGLDKEFNAIFRRAFASRVFPPELVEQLGIKHVKGILLYGPPGTGKTLMARQIGTMLNAREPKI 289
            :|||.:..::: |......:..|..:..||:...:|:||.||||.|||.:.|.:.....| |...
Human   202 LGGLSEAADSL-RELLRLPLRYPRALTALGLAVPRGVLLAGPPGVGKTQLVRAVAREAGA-ELLA 264

  Fly   290 VNGPQILDKYVGESEANIRRLFAEAEEEEKRLGPNSGLHIIIFDEIDAICKARGSVAGNSGVHDT 354
            |:.|.:.....||:|.|:||:|..|.|...| ||:    ::..||:||:|..|||.|..|    .
Human   265 VSAPALQGSRPGETEENVRRVFQRARELASR-GPS----LLFLDEMDALCPQRGSRAPES----R 320

  Fly   355 VVNQLLAKIDGVEQLNNILVIGMTNRRDMIDEALLRPGRLEVQMEISLPNEQGRVQILNIHTKRM 419
            ||.|:|..:||......::|:|.|||.|.:|.||.||||.:.::.|..|..:.|.:||.:.|.:|
Human   321 VVAQVLTLLDGASGDREVVVVGATNRPDALDPALRRPGRFDREVVIGTPTLKQRKEILQVITSKM 385

  Fly   420 RDFNKIASDVDNNEIAAKTKNFSGAELEGLVRAAQSTAMNRLIKADSKVHVDPEAMEKLRVTRAD 484
                .|:|.||...:|..|..:.||:|..|.|.|   ||:.|:  .|:.:.|...::::     |
Human   386 ----PISSHVDLGLLAEMTVGYVGADLTALCREA---AMHALL--HSEKNQDNPVIDEI-----D 436

  Fly   485 FLHALDN-------------DIKPA----FGAAQEMLENLLARGIINWGPPVTELLEDGMLSVQQ 532
            ||.|..|             ||||.    .|..:::  .|..:..|.|  |:....|...:.:.|
Human   437 FLEAFKNIQPSSFRSVIGLMDIKPVDWEEIGGLEDV--KLKLKQSIEW--PLKFPWEFVRMGLTQ 497

  Fly   533 AKATESSGLVSVLIEGAPNSGKSALAANLAQLSDFPFVKVCSPE---DMVGFTESAKCLHIRKIF 594
            .|        .||:.|.|...|:.|...||......||.|...:   ..||.:|..    :.:||
Human   498 PK--------GVLLYGPPGCAKTTLVRALATSCHCSFVSVSGADLFSPFVGDSEKV----LSQIF 550

  Fly   595 DDAYRSTLSCIVVDNVERLLDYGPIGPRYSNLT--------LQALL-----VLLKKQPPKG---- 642
            ..|..||.:.:.:|.::.:|     |.|.::.|        |..||     |.||....:|
Human   551 RQARASTPAILFLDEIDSIL-----GARSASKTGCDVQERVLSVLLNELDGVGLKTIERRGSKSS 610

  Fly   643 ---------RKLLILCTSSRRDVLE----------------------EMEMLSAFTSVLHVSNLS 676
                     |.::|:..::|.|||:                      .:.:|...|..:.:....
Human   611 QQEFQEVFNRSVMIIAATNRPDVLDTALLRPGRLDKIIYIPPPDHKGRLSILKVCTKTMPIGPDV 675

  Fly   677 TPENVLAVLDDSDLFSPEELQSIARKMAGKRLCIGIKKLLAL----IDMIRQSEPHQRVIKFLSK 737
            :.||:.|   ::..||..:|:::..:.|          ||||    :|.....:.|     ||..
Human   676 SLENLAA---ETCFFSGADLRNLCTEAA----------LLALQENGLDATTVKQEH-----FLKS 722

  Fly   738 ME 739
            ::
Human   723 LK 724

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.