DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nsf2 and Iqca

DIOPT Version :9

Sequence 1:	NP_001287318.1	Gene:	Nsf2 / 41694	FlyBaseID:	FBgn0266464	Length:	752	Species:	Drosophila melanogaster
Sequence 2:	NP_001355651.1	Gene:	Iqca / 74918	MGIID:	1922168	Length:	838	Species:	Mus musculus

Alignment Length:	501	Identity:	97/501 - (19%)
Similarity:	180/501 - (35%)	Gaps:	141/501 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   302 ESEANIRRLFAEAEEEEKRLGPNSGLHIIIFDEIDAICKARGSVAGNSGVHDTVVNQLLAKIDGV 366
            |.:.:::....:.|:||.::.|:  |.:.:.:|            |||...|..:|:
Mouse   376 EKKVSLKEKAMKDEDEEWKMSPS--LFLQLMEE------------GNSLYKDIWLNK-------- 418

  Fly   367 EQLNNILVIGMTNRRDMIDEALLRPGRLEVQMEISLPNEQGRVQILNIHTKRMRDFNKIA----S 427
            ::..|.       .:|...|.:....|.|::|||       |||:..:..:.:::. |:|    .
Mouse   419 DESWNF-------PQDYDPELIKEEKRKELEMEI-------RVQVDELMRQELKNL-KLAVNREM 468

  Fly   428 DVDNNEIAAKTKNFSGAELEGLVRAAQSTAMNRLIKADSKVHVDPEAMEKLRVTRADFLHALDND 492
            ::...:...|.|| .|.:    .|..:.....:.:.||..:    |::.:..|.:...:.||..:
Mouse   469 EIPPRQKKGKKKN-KGRK----GRRGKRGKKEKDLTADRTI----ESLYQELVEKGLLIQALKVN 524

  Fly   493 IKPAFGAAQEMLENLLARGIINWGPPVTELLE-------DGMLSVQQAKATESSGLV-SVLIEGA 549
            :....|....:...|....|    .|:..||:       .|:|.:..|:..|.:.|| |:|:.|.
Mouse   525 LSDYIGEYSYLGTTLRQVAI----EPMPSLLDVRQLITLYGILPLGSAEVHERAPLVKSLLLAGP 585

  Fly   550 PNSGKSAL--------AANLAQLS------DFPFVKVCSPEDMVGFTESAKCLHIRKIFDDAYRS 600
            ...||..|        .|||..||      .:|           |.|.....:|:  :|..|.:.
Mouse   586 SGVGKKMLVHAICTETGANLFNLSALNIAGKYP-----------GKTGLQMMIHL--VFKVARQL 637

  Fly   601 TLSCIVVDNVERLLDYGPI-------GPRYSNLTLQALLVLLKKQPPKGRKLLILCTSSRRDVLE 658
            ..|.:.:.:.|:.. |..:       .|:.....|..||.|||   |..| :||:.|:.|....|
Mouse   638 QPSVVWIQDTEKTF-YKKVPQAEKRFEPKRLKRYLPKLLKLLK---PDDR-ILIVGTTHRPFDAE 697

  Fly   659 EMEMLSAFTSVLHV--------------------SNLSTPENVLAVLDDSDLFSPEELQSIARKM 703
            .......:..::.|                    ..|:...|:..:...:|.|:..::..:
Mouse   698 LQPFCRVYQKIILVPRPDYASRYVLWKEIILRNGGKLTNSLNISCLSKVTDGFTQGQIVQV---- 758

  Fly   704 AGKRLCIGIKKLLALIDMIRQSEPHQRVIKFLSKM--------EEE 741
                    ||.:|....:.:|:......|:|::.|        |||
Mouse   759 --------IKDVLTERRLRQQAHKPLTAIEFITMMTNMNPVYREEE 796

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nsf2	NP_001287318.1	CDC48_N	9..89	CDD:215012
		CDC48_2	117..>170	CDD:215011
		AAA	259..404	CDD:214640	20/101 (20%)
		AAA	261..402	CDD:278434	20/99 (20%)
		AAA	543..674	CDD:214640	35/171 (20%)
		P-loop_NTPase	544..>613	CDD:304359	18/82 (22%)
Iqca	NP_001355651.1	SpoVK	<578..797	CDD:223540	49/249 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900