DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nsf2 and Atad1

DIOPT Version :9

Sequence 1:	NP_001287318.1	Gene:	Nsf2 / 41694	FlyBaseID:	FBgn0266464	Length:	752	Species:	Drosophila melanogaster
Sequence 2:	NP_080763.2	Gene:	Atad1 / 67979	MGIID:	1915229	Length:	361	Species:	Mus musculus

Alignment Length:	380	Identity:	95/380 - (25%)
Similarity:	163/380 - (42%)	Gaps:	92/380 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   159 LEAVDPRTVGDSLPKTRNVRFGRILGNTVVQFEKAENSVLNLQGRSKGKI------VRQSIINP- 216
            ::|:||         ||..:         |:.:|....::...|....|:      :...:::|
Mouse    38 VDAIDP---------TRKQK---------VEAQKQAEKLMKQIGVKNVKLSEYEMSIAAHLVDPL 84

  Fly   217 ----DWDFGKMGIGGLDKEFNAI---------FRRAFA-SRVFPPELVEQLGIKHVKGILLYGPP 267
                .|.    .|.|||.....:         .:..|. ||:..|.          ||:||||||
Mouse    85 NMHVTWS----DIAGLDDVITDLKDTVILPIKKKHLFENSRLLQPP----------KGVLLYGPP 135

  Fly   268 GTGKTLMARQIGTMLNAREP--KIVN-GPQIL-DKYVGESEANIRRLFAEAEEEEKRLGPNSGLH 328
            |.||||:|:     ..|:|.  :.:| .|..| ||:.|||:.....:|:.|    .:|.|:
Mouse   136 GCGKTLIAK-----ATAKEAGCRFINLQPSTLTDKWYGESQKLAAAVFSLA----IKLQPS---- 187

  Fly   329 IIIFDEIDAICKARGSVAGNSGVHDTVV---NQLLAKIDGVEQLNN--ILVIGMTNRRDMIDEAL 388
            ||..||||:..:.|     :|..|:...   .|.::..||::..::  ::|:|.|||...:|.|:
Mouse   188 IIFIDEIDSFLRNR-----SSSDHEATAMMKAQFMSLWDGLDTDHSCQVIVMGATNRPQDLDSAI 247

  Fly   389 LRPGRLEVQMEISLPNEQGRVQILNIHTKRMRDFNKIASDVDNNEIAAKTKNFSGAELEGLVRAA 453
            :|  |:..:..|:.|..:.|..||.:..|.    ..:...||..|:|.:|..|||::|:.:.|.|
Mouse   248 MR--RMPTRFHINQPALKQREAILKLILKN----ENVDRHVDLLEVAQETDGFSGSDLKEMCRDA 306

  Fly   454 QSTAMNRLIKADSKVHVDPEAMEKLRVTRADFLHALDNDIKPAFGAAQEMLENLL 508
            ....:...:.:.|:...|.   :::|..:...||.....:|.:..||   .:|:|
Mouse   307 ALLCVREYVNSTSEESHDE---DEIRPVQQQDLHRAIEKMKKSKDAA---FQNVL 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nsf2	NP_001287318.1	CDC48_N	9..89	CDD:215012
		CDC48_2	117..>170	CDD:215011	3/10 (30%)
		AAA	259..404	CDD:214640	50/153 (33%)
		AAA	261..402	CDD:278434	48/149 (32%)
		AAA	543..674	CDD:214640
		P-loop_NTPase	544..>613	CDD:304359
Atad1	NP_080763.2	RecA-like_ATAD1	92..257	CDD:410928	57/194 (29%)
Atad1	NP_080763.2	AAA_lid_3	282..321	CDD:407720	12/38 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900