DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nsf2 and Nvl

DIOPT Version :9

Sequence 1:	NP_001287318.1	Gene:	Nsf2 / 41694	FlyBaseID:	FBgn0266464	Length:	752	Species:	Drosophila melanogaster
Sequence 2:	NP_080447.1	Gene:	Nvl / 67459	MGIID:	1914709	Length:	855	Species:	Mus musculus

Alignment Length:	624	Identity:	161/624 - (25%)
Similarity:	254/624 - (40%)	Gaps:	170/624 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   200 LQGRSKGKIVRQSIINPDWDFGKMGIGGLDKEFNAIFRRAFASRVFPPELVEQLGIKHVKGILLY 264
            ||.::|.:.....|.|..::    .:||.|.....:.:.....|  .||:.:.||:...:|:||:
Mouse   245 LQKKAKARSTELQISNVKFE----DVGGNDATLKEVCKMLIHMR--HPEVYQHLGVVPPRGVLLH 303

  Fly   265 GPPGTGKTLMARQIGTMLNAREPKIVNGPQILDKYVGESEANIRRLFAEAEEEEKRLGPNSGLHI 329
            ||||.||||:|..|...|:....|:. .|:|:....||||..:|.||.:|        .::...|
Mouse   304 GPPGCGKTLLAHAIAGELDLPILKVA-APEIVSGVSGESEQKLRELFDQA--------VSNAPCI 359

  Fly   330 IIFDEIDAICKARGSVAGNSGVHDTVVNQLLAKIDGVEQLNN------ILVIGMTNRRDMIDEAL 388
            :..||||||...| .|| :..:...:|.|||..:|   .|||      :||||.|||.|.:|.||
Mouse   360 VFIDEIDAITPKR-EVA-SKDMERRIVAQLLTCMD---DLNNVAATARVLVIGATNRPDSLDPAL 419

  Fly   389 LRPGRLEVQMEISLPNEQGRVQILNIHTKRMR---DFNKIASDVDNNEIAAKTKNFSGAELEGLV 450
            .|.||.:.::.:.:|:|..|.:||....:::|   .||..       .:|..|..|.||:|..|.
Mouse   420 RRAGRFDREVCLGIPDEAARERILQTLCRKLRLPETFNFC-------HLAHLTPGFVGADLMALC 477

  Fly   451 RAAQSTAMNR-LIKADSKVHVDPEAMEKLRVTRADFLHALDNDIKPAFGA-----AQEMLENLLA 509
            |.|...|:|| |:|..::....|| :|.|         ..:.|.:...||     .|:.|:.||
Mouse   478 REAAMCAVNRVLMKQQAQQKKKPE-IEGL---------PSEGDQEERLGAEPTSETQDELQRLL- 531

  Fly   510 RGIINWGPPVTE--------LLEDGMLSVQQAK-ATESSGLVSV--------------------- 544
             |::....|::|        .|.|.::::.:.: :.:..|.|:|
Mouse   532 -GLLRDQDPLSEEQMQGLCIELNDFIVALAEVQPSAKREGFVTVPNVTWADIGALEDIRDELIMA 595

  Fly   545 ----------------------LIEGAPNSGKSALAANLAQLSDFPFVKVCSPEDM---VGFTES 584
                                  |:.|.|..||:.||..:|..|...|:.|..||.:   ||.:|.
Mouse   596 ILAPVRNPDQFRTLGLGTPAGILLAGPPGCGKTLLAKAVANESGLNFISVKGPELLNMYVGESER 660

  Fly   585 AKCLHIRKIFDDAYRSTLSCIVVDNVERLLDYGPIGPRYSNLTLQALLVLLKKQPPKGRKLLILC 649
            |    :|::|..|..|....|..|.|:.|.      ||.|:....|.:.::.:
Mouse   661 A----VRQVFQRAKNSAPCVIFFDEVDALC------PRRSDRETGASVRVVNQ------------ 703

  Fly   650 TSSRRDVLEEMEMLSAFTSVLHVSNLSTPENVLAVLDDSDLFSPEELQSIARKMAGKRLCIGIKK 714
                  :|.||:.|.....|.          :||..:..|:..|..|:.   ....|.|.:|:
Mouse   704 ------LLTEMDGLETRQQVF----------ILAATNRPDIIDPAILRP---GRLDKTLFVGL-- 747

  Fly   715 LLALIDMIRQSEPHQRV--IKFLSK------MEEEGGLE 745
                      ..|..||  :|.::|      ::|:..||
Mouse   748 ----------PPPADRVAILKTITKNGTKPPLDEDVNLE 776

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nsf2	NP_001287318.1	CDC48_N	9..89	CDD:215012
		CDC48_2	117..>170	CDD:215011
		AAA	259..404	CDD:214640	57/150 (38%)
		AAA	261..402	CDD:278434	56/146 (38%)
		AAA	543..674	CDD:214640	35/176 (20%)
		P-loop_NTPase	544..>613	CDD:304359	25/114 (22%)
Nvl	NP_080447.1	Interaction with RPL5. /evidence=ECO:0000250\|UniProtKB:O15381	1..219
		Nucleolin_bd	2..72	CDD:293330
		Nucleolar localization signal. /evidence=ECO:0000269\|PubMed:21474449	49..52
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	83..234
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:O15381	85..88
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:O15381	217..231
		Interaction with WDR74. /evidence=ECO:0000250\|UniProtKB:O15381	266..473		78/229 (34%)
		SpoVK	283..842	CDD:223540	153/582 (26%)
		AAA	300..432	CDD:278434	56/145 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	496..523		7/36 (19%)
		AAA	617..747	CDD:278434	41/170 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900