DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nsf2 and Fignl1

DIOPT Version :9

Sequence 1:	NP_001287318.1	Gene:	Nsf2 / 41694	FlyBaseID:	FBgn0266464	Length:	752	Species:	Drosophila melanogaster
Sequence 2:	XP_011242039.1	Gene:	Fignl1 / 60530	MGIID:	1890648	Length:	692	Species:	Mus musculus

Alignment Length:	359	Identity:	101/359 - (28%)
Similarity:	153/359 - (42%)	Gaps:	80/359 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   159 LEAVDPRTV----GDSLPKTRNVRFGRILGNTVVQFEKAENSVLNLQGRSKGKIVRQSIINPDWD 219
            |:.|:||.|    .:.:.....|.:..|.|   |:|.||          :..:||...::.||..
Mouse   394 LKNVEPRMVELIMNEIMDHGPPVHWDDIAG---VEFAKA----------TIKEIVVWPMMRPDIF 445

  Fly   220 FGKMGIGGLDKEFNAIFRRAFASRVFPPELVEQLGIKHVKGILLYGPPGTGKTLMARQIGTMLNA 284
            .|..|                     ||           |||||:|||||||||:.:.|.:...|
Mouse   446 TGLRG---------------------PP-----------KGILLFGPPGTGKTLIGKCIASQSGA 478

  Fly   285 REPKIVNGPQILDKYVGESEANIRRLFAEAEEEEKRLGPNSGLHIIIFDEIDAICKARGSVAGNS 349
            ....| :...:..|:|||.|..:|.|||.|..::..        :|..||||::...||     .
Mouse   479 TFFSI-SASSLTSKWVGEGEKMVRALFAVARCQQPA--------VIFIDEIDSLLSQRG-----D 529

  Fly   350 GVHDT---VVNQLLAKIDG--VEQLNNILVIGMTNRRDMIDEALLRPGRLEVQMEISLPNEQGRV 409
            |.|::   :..:.|.::||  ....:.|||:|.|||...||||..|  ||..::.|.||....|.
Mouse   530 GEHESSRRIKTEFLVQLDGATTSSEDRILVVGATNRPQEIDEAARR--RLVKRLYIPLPEASARK 592

  Fly   410 QIL-NIHTKRMRDFNKIASDVDNNEIAAKTKNFSGAELEGLVRAAQSTAMNRLIKADSKVHVDPE 473
            ||: |:.:|.    ....||.:.:.:..::..||||::..|.|.|....:..|..||... :.|:
Mouse   593 QIVGNLMSKE----QCCLSDEETDLVVQQSDGFSGADMTQLCREASLGPIRSLHAADIAT-ISPD 652

  Fly   474 AMEKLRVTRADFLHALDNDIKPAFGAAQ-EMLEN 506
            .:..  :...||.:|. ..::|...... |:.||
Mouse   653 QVRP--IAYIDFENAF-KTVRPTVSPKDLELYEN 683

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nsf2	NP_001287318.1	CDC48_N	9..89	CDD:215012
		CDC48_2	117..>170	CDD:215011	5/14 (36%)
		AAA	259..404	CDD:214640	55/149 (37%)
		AAA	261..402	CDD:278434	52/145 (36%)
		AAA	543..674	CDD:214640
		P-loop_NTPase	544..>613	CDD:304359
Fignl1	XP_011242039.1	RecA-like_Figl-1	398..583	CDD:410933	71/245 (29%)
		AAA_lid_3	608..>639	CDD:407720	8/30 (27%)
		Vps4_C	<649..689	CDD:401324	8/38 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900