DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nsf2 and Nsf

DIOPT Version :9

Sequence 1:	NP_001287318.1	Gene:	Nsf2 / 41694	FlyBaseID:	FBgn0266464	Length:	752	Species:	Drosophila melanogaster
Sequence 2:	NP_068516.2	Gene:	Nsf / 60355	RGDID:	621594	Length:	744	Species:	Rattus norvegicus

Alignment Length:	741	Identity:	470/741 - (63%)
Similarity:	584/741 - (78%)	Gaps:	6/741 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 MRAIKCPTDELSLTNKAIVNVSDFTEEVKYVDISPGPGLHYIFALEKISGPELPLGHVGFSLVQR 73
            |:|.:||||||||:|.|:||..|: :..::|.:...|...|||.|.  :.|.:..|.:.|||.||
  Rat     6 MQAARCPTDELSLSNCAVVNEKDY-QSGQHVMVRTSPNHKYIFTLR--THPSVVPGCIAFSLPQR 67

  Fly    74 KWATLSINQEIDVRPYRFDASADIITLVSFETDFLQKKTTTQEPYDSDEMAKEFLMQFAGMPLTV 138
            |||.|||.|:|:|..|.||.:...|..::.|.||||||.....|||:|:||.||:.||.....:|
  Rat    68 KWAGLSIGQDIEVALYSFDKAKQCIGTMTIEIDFLQKKNIDSNPYDTDKMAAEFIQQFNNQAFSV 132

  Fly   139 GQTLVFQFKDKKFLGLAVKTLEAVDPRTV-GD-SLPKTRNVRFGRILGNTVVQFEKAENSVLNLQ 201
            ||.|||.|.||.| ||.||.:||:||..: |: :..|.:.:..|.::||:.|.|||||||.|||.
  Rat   133 GQQLVFSFNDKLF-GLLVKDIEAMDPSILKGEPASGKRQKIEVGLVVGNSQVAFEKAENSSLNLI 196

  Fly   202 GRSKGKIVRQSIINPDWDFGKMGIGGLDKEFNAIFRRAFASRVFPPELVEQLGIKHVKGILLYGP 266
            |::|.|..|||||||||:|.|||||||||||:.||||||||||||||:|||:|.|||||||||||
  Rat   197 GKAKTKENRQSIINPDWNFEKMGIGGLDKEFSDIFRRAFASRVFPPEIVEQMGCKHVKGILLYGP 261

  Fly   267 PGTGKTLMARQIGTMLNAREPKIVNGPQILDKYVGESEANIRRLFAEAEEEEKRLGPNSGLHIII 331
            ||.||||:|||||.||||||||:||||:||:|||||||||||:|||:||||::|||.||||||||
  Rat   262 PGCGKTLLARQIGKMLNAREPKVVNGPEILNKYVGESEANIRKLFADAEEEQRRLGANSGLHIII 326

  Fly   332 FDEIDAICKARGSVAGNSGVHDTVVNQLLAKIDGVEQLNNILVIGMTNRRDMIDEALLRPGRLEV 396
            |||||||||.|||:||::|||||||||||:|||||||||||||||||||.|:|||||||||||||
  Rat   327 FDEIDAICKQRGSMAGSTGVHDTVVNQLLSKIDGVEQLNNILVIGMTNRPDLIDEALLRPGRLEV 391

  Fly   397 QMEISLPNEQGRVQILNIHTKRMRDFNKIASDVDNNEIAAKTKNFSGAELEGLVRAAQSTAMNRL 461
            :|||.||:|:||:|||:|||.|||....:::|||..|:|.:|||||||||||||||||||||||.
  Rat   392 KMEIGLPDEKGRLQILHIHTARMRGHQLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRH 456

  Fly   462 IKADSKVHVDPEAMEKLRVTRADFLHALDNDIKPAFGAAQEMLENLLARGIINWGPPVTELLEDG 526
            |||.:||.||.|..|.|:|||.|||.:|:||||||||..||...:.:..|||.||.|||.:|:||
  Rat   457 IKASTKVEVDMEKAESLQVTRGDFLASLENDIKPAFGTNQEDYASYIMNGIIKWGDPVTRVLDDG 521

  Fly   527 MLSVQQAKATESSGLVSVLIEGAPNSGKSALAANLAQLSDFPFVKVCSPEDMVGFTESAKCLHIR 591
            .|.|||.|.::.:.|||||:||.|:|||:||||.:|:.|:|||:|:|||:.|:||:|:|||..::
  Rat   522 ELLVQQTKNSDRTPLVSVLLEGPPHSGKTALAAKIAEESNFPFIKICSPDKMIGFSETAKCQAMK 586

  Fly   592 KIFDDAYRSTLSCIVVDNVERLLDYGPIGPRYSNLTLQALLVLLKKQPPKGRKLLILCTSSRRDV 656
            |||||||:|.|||:|||::||||||.|||||:|||.||||||||||.||:||||||:.|:||:||
  Rat   587 KIFDDAYKSQLSCVVVDDIERLLDYVPIGPRFSNLVLQALLVLLKKAPPQGRKLLIIGTTSRKDV 651

  Fly   657 LEEMEMLSAFTSVLHVSNLSTPENVLAVLDDSDLFSPEELQSIARKMAGKRLCIGIKKLLALIDM 721
            |:|||||:||::.:||.|::|.|.:|..|:....|..:|..:||:::.||::.|||||||.||:|
  Rat   652 LQEMEMLNAFSTTIHVPNIATGEQLLEALELLGNFKDKERTTIAQQVKGKKVWIGIKKLLMLIEM 716

  Fly   722 IRQSEPHQRVIKFLSKMEEEGGLEMD 747
            ..|.:|..||.|||:.|.|||...:|
  Rat   717 SLQMDPEYRVRKFLALMREEGASPLD 742

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nsf2	NP_001287318.1	CDC48_N	9..89	CDD:215012	37/79 (47%)
		CDC48_2	117..>170	CDD:215011	29/54 (54%)
		AAA	259..404	CDD:214640	124/144 (86%)
		AAA	261..402	CDD:278434	121/140 (86%)
		AAA	543..674	CDD:214640	90/130 (69%)
		P-loop_NTPase	544..>613	CDD:304359	43/68 (63%)
Nsf	NP_068516.2	CDC48_N	6..83	CDD:215012	37/79 (47%)
		CDC48_2	111..183	CDD:215011	33/72 (46%)
		CDC48	159..>606	CDD:273521	314/446 (70%)
		RecA-like_NSF-SEC18_r1-like	219..395	CDD:410912	151/175 (86%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341634
Domainoid	1	1.000	247	1.000	Domainoid score	I2084
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4502
Inparanoid	1	1.050	905	1.000	Inparanoid score	I355
OMA	1	1.010	-	-		QHG52406
OrthoDB	1	1.010	-	-		D156590at33208
OrthoFinder	1	1.000	-	-		FOG0003053
OrthoInspector	1	1.000	-	-		otm44990
orthoMCL	1	0.900	-	-		OOG6_101440
Panther	1	1.100	-	-	LDO	PTHR23078
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2410
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.910