DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nsf2 and Fign

DIOPT Version :9

Sequence 1:	NP_001287318.1	Gene:	Nsf2 / 41694	FlyBaseID:	FBgn0266464	Length:	752	Species:	Drosophila melanogaster
Sequence 2:	NP_068362.1	Gene:	Fign / 60344	MGIID:	1890647	Length:	759	Species:	Mus musculus

Alignment Length:	336	Identity:	86/336 - (25%)
Similarity:	144/336 - (42%)	Gaps:	60/336 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   191 EKAENSVLNLQGRSKGKIVRQSIINP--DWDFGKMGIGGLDKEFNAIFRRAFASRVFPPELVEQL 253
            |:.:|:..:|......:|:.|   .|  ||.    .|.|||     :.:......|..|.|....
Mouse   459 EQLKNTDTHLIDLVTNEIITQ---GPPVDWS----DIAGLD-----LVKAVIKEEVLWPVLRSDA 511

  Fly   254 --GIKHV-KGILLYGPPGTGKTLMARQIGTMLNAREPKIVNGPQILDKYVGESEANIRRLFAEAE 315
              |:..: :.|||:||.||||||:.|.|.:.|.|...||. |..::.|::||:|..|...|..|.
Mouse   512 FSGLTALPRSILLFGPRGTGKTLLGRCIASQLGATFFKIA-GSGLVAKWIGEAEKIIHASFLVAR 575

  Fly   316 EEEKRLGPNSGLHIIIFDEIDAICKARGSVAGNSGVHDTVV---NQLLAKIDGV--EQLNNILVI 375
            ..:    |:    :|...:||.:..::.|..     |..|.   .:.|.::|.|  ...:.|:||
Mouse   576 CRQ----PS----VIFVSDIDMLLSSQVSEE-----HSPVSRMRTEFLMQLDTVLTSAEDQIVVI 627

  Fly   376 GMTNRRDMIDEALLRPGRLEVQMEISLPNEQGRVQILNIHTKRMRDFNKIASDVDNNEIAAKTKN 440
            ..|::.:.|||:|.|  ....::.|.||:...|.||:   .:.:...|...:|.:...:..:|:.
Mouse   628 CATSKPEEIDESLRR--YFMKRLLIPLPDSTARHQII---VQLLTQHNYCLNDKEFALLVQRTEG 687

  Fly   441 FSGAELEGLVRAAQSTAMNRLIKADSKVHVDPEAMEKLRVTRADFLHALDNDIKPA--------- 496
            |||.::..|.:.|....::.:...|... :.|..:..  ||..||.:|... |:|:
Mouse   688 FSGLDVAHLCQEAAVGPLHAMPATDLSA-IMPSQLRP--VTYQDFENAFCK-IQPSISQKELDMY 748

  Fly   497 ------FGAAQ 501
                  ||.:|
Mouse   749 VEWNKMFGCSQ 759

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nsf2	NP_001287318.1	CDC48_N	9..89	CDD:215012
		CDC48_2	117..>170	CDD:215011
		AAA	259..404	CDD:214640	46/149 (31%)
		AAA	261..402	CDD:278434	45/145 (31%)
		AAA	543..674	CDD:214640
		P-loop_NTPase	544..>613	CDD:304359
Fign	NP_068362.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	89..111
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	200..237
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	258..293
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	337..429
		26Sp45	389..736	CDD:130309	81/311 (26%)
		AAA	522..652	CDD:278434	45/145 (31%)
		Vps4_C	<723..756	CDD:286426	7/35 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900