DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nsf2 and zgc:136908

DIOPT Version :9

Sequence 1:	NP_001287318.1	Gene:	Nsf2 / 41694	FlyBaseID:	FBgn0266464	Length:	752	Species:	Drosophila melanogaster
Sequence 2:	NP_001035017.1	Gene:	zgc:136908 / 563679	ZFINID:	ZDB-GENE-060312-22	Length:	805	Species:	Danio rerio

Alignment Length:	614	Identity:	176/614 - (28%)
Similarity:	277/614 - (45%)	Gaps:	130/614 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   159 LEAVDPRTVGDSLPKTRNVRFG-RILGNTVVQFEK------AENSVLNLQGRSKGKIVRQSIINP 216
            |||..|...||..    .||.| |.:...||:.:.      |.:::::.:|....:...:..:|
Zfish   142 LEAYRPVHKGDIF----LVRGGMRAVEFKVVETDPTPHCIVAPDTIIHCEGEPIKREDEEESLN- 201

  Fly   217 DWDFGKMGIGGLDKEFNAIFRRAFASRVFPPELVEQLGIKHVKGILLYGPPGTGKTLMARQIGTM 281
              |.|...|||..|:. |..:......:..|.|.:.:|:|..:||||||||||||||:||.:
Zfish   202 --DIGYDDIGGCRKQL-AQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLVARAV--- 260

  Fly   282 LNAREPK----IVNGPQILDKYVGESEANIRRLFAEAEEEEKRLGPNSGLHIIIFDEIDAICKAR 342
              |.|..    ::|||:|:.|..||||:|:|:.|.|||:....        ||..||:|||...|
Zfish   261 --ANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPA--------IIFIDELDAIAPKR 315

  Fly   343 GSVAGNSGVHDTVVNQLLAKIDGVEQLNNILVIGMTNRRDMIDEALLRPGRLEVQMEISLPNEQG 407
            ....|.  |...:|:|||..:||::|..:::|:..|||.:.:|.||.|.||.:.:::|.:|:..|
Zfish   316 EKTHGE--VERRIVSQLLTLMDGLKQRAHVVVMAATNRPNSVDAALRRFGRFDREIDIGIPDSTG 378

  Fly   408 RVQILNIHTKRMRDFNKIASDVDNNEIAAKTKNFSGAELEGLVRAAQSTAMNRL-----IKADSK 467
            |::||.||||.|    |::.|||..:|:|:|....||:|..|...|...|:.:.     ::.||
Zfish   379 RLEILQIHTKNM----KLSEDVDLEQISAETHGHVGADLAALCSEAALQAIRKKMTLIDLEDDS- 438

  Fly   468 VHVDPEAMEKLRVTRADFLHALDNDIKPAFGAAQEMLENLLARGIINWGP--------------- 517
              :|.:.:..|.||..||..||......|      :.|.::....:||..
Zfish   439 --IDADLLNSLAVTMDDFKWALSQSNPSA------LRETVVEVPHVNWEDIGGLDEVKRELQELV 495

  Fly   518 --PV---TELLEDGMLSVQQAKATESSGLVSVLIEGAPNSGKSALAANLAQLSDFPFVKVCSPED 577
              ||   .:.|:.||        |.|.|   ||..|.|..||:.||..:|......||.:..||.
Zfish   496 QYPVEYPDKFLKFGM--------TPSRG---VLFYGPPGCGKTLLAKAIANECQANFVSIKGPEL 549

  Fly   578 M-VGFTESAKCLHIRKIFDDAYRSTLSCIV----VDNVERLL-----DYGPIGPRYSNLTLQALL 632
            : :.|.||.  .::|.:||.| |....||:    :|::.:..     |.|....|..|..|..:.
Zfish   550 LTMWFGESE--ANVRDVFDKA-RQAAPCILFFDELDSIAKARGGGAGDAGGAADRVINQILTEMD 611

  Fly   633 VLLKKQPPKGRKLLILCTSSRRDVLE---------------EMEMLSAFTSVLHVSNLSTPENVL 682
            .:..|     :.:.|:..::|.|:::               .:..:.:.|::|..:...:|
Zfish   612 GMTNK-----KNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPDMPSRTAILRANLRKSP---- 667

  Fly   683 AVLDDSDL---------FSPEELQSIARK 702
             |..|.||         ||..:|..|.::
Zfish   668 -VAKDVDLMYLSKITEGFSGADLTEICQR 695

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nsf2	NP_001287318.1	CDC48_N	9..89	CDD:215012
		CDC48_2	117..>170	CDD:215011	5/10 (50%)
		AAA	259..404	CDD:214640	61/148 (41%)
		AAA	261..402	CDD:278434	60/144 (42%)
		AAA	543..674	CDD:214640	35/155 (23%)
		P-loop_NTPase	544..>613	CDD:304359	24/73 (33%)
zgc:136908	NP_001035017.1	CDC48	27..766	CDD:273521	176/614 (29%)
		CDC48_N	27..109	CDD:280513
		CDC48_2	133..193	CDD:215011	14/54 (26%)
		AAA	243..372	CDD:278434	59/143 (41%)
		AAA	516..649	CDD:278434	33/140 (24%)
		Vps4_C	<731..762	CDD:286426
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810