DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nsf2 and spast

DIOPT Version :9

Sequence 1:	NP_001287318.1	Gene:	Nsf2 / 41694	FlyBaseID:	FBgn0266464	Length:	752	Species:	Drosophila melanogaster
Sequence 2:	XP_012818464.1	Gene:	spast / 549207	XenbaseID:	XB-GENE-947839	Length:	603	Species:	Xenopus tropicalis

Alignment Length:	342	Identity:	95/342 - (27%)
Similarity:	162/342 - (47%)	Gaps:	48/342 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   165 RTVGDSLPKTR------NVRFGRILGNTVVQFEKAENSVLNLQGRSKGKIVRQSI-INPDWDFGK 222
            |..|.:.|..|      |.|..:....|....:|...::.|:.......|:.:.: ..|...|.
Frog   266 RQAGPNAPSNRGAAGKNNTRTNKPTTPTTAVRKKDMKNLRNVDSNLANLILNEIVDSGPTVKFA- 329

  Fly   223 MGIGGLDKEFNAIFRRAFASRVFPPELVEQL--GIK-HVKGILLYGPPGTGKTLMARQIGTMLNA 284
             .|.|.|     :.::|....|..|.:..:|  |:: ..:|:||:||||.|||::|:.:....||
Frog   330 -DIAGQD-----LAKQALQEIVILPSIRPELFTGLRAPARGLLLFGPPGNGKTMLAKAVAAESNA 388

  Fly   285 REPKIVNGPQILDKYVGESEANIRRLFAEAEEEEKRLGPNSGLHIIIFDEIDA-ICKARGSVAGN 348
            ....| :...:..|||||.|..:|.||:.|.|    |.|:    ||..||:|: :|:.|
Frog   389 TFFNI-SAASLTSKYVGEGEKLVRALFSVARE----LQPS----IIFIDEVDSLLCERR------ 438

  Fly   349 SGVHDT---VVNQLLAKIDGVEQ--LNNILVIGMTNRRDMIDEALLRPGRLEVQMEISLPNEQGR 408
            .|.||.   :..:.|.:.|||:.  .:.:||:|.|||...:|:|:||  |...::.:|||||:.|
Frog   439 EGEHDASRRLKTEFLIEFDGVQSGGDDRVLVMGATNRPQELDDAVLR--RFTKRVYVSLPNEETR 501

  Fly   409 VQIL-NIHTKRMRDFNKIASDVDNNEIAAKTKNFSGAELEGLVRAAQSTAMNRLIKADSKVHVDP 472
            :.:| |:.:|:....|    :.:..:::..|:.:||:::..|.:.|....:..|.....|   :.
Frog   502 LLLLKNLLSKQGNPLN----EKELTQLSRLTEGYSGSDITALAKDAALGPIRELKPEQVK---NM 559

  Fly   473 EAMEKLRVTRADFLHAL 489
            .|.|...:..:|||.:|
Frog   560 AASEMRNIKYSDFLSSL 576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nsf2	NP_001287318.1	CDC48_N	9..89	CDD:215012
		CDC48_2	117..>170	CDD:215011	2/4 (50%)
		AAA	259..404	CDD:214640	54/150 (36%)
		AAA	261..402	CDD:278434	51/146 (35%)
		AAA	543..674	CDD:214640
		P-loop_NTPase	544..>613	CDD:304359
spast	XP_012818464.1	MIT_spastin	110..188	CDD:239142
spast	XP_012818464.1	SpoVK	<278..584	CDD:223540	91/330 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910