DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nsf2 and ATAD2B

DIOPT Version :9

Sequence 1:	NP_001287318.1	Gene:	Nsf2 / 41694	FlyBaseID:	FBgn0266464	Length:	752	Species:	Drosophila melanogaster
Sequence 2:	XP_011531220.1	Gene:	ATAD2B / 54454	HGNCID:	29230	Length:	1511	Species:	Homo sapiens

Alignment Length:	658	Identity:	175/658 - (26%)
Similarity:	278/658 - (42%)	Gaps:	165/658 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   192 KAENSVLNLQGRSK---GKIVRQSI-----------INPDWDFGKMGIGGLDKEFNAIFRRAFAS 242
            :|.|..|.:..|::   ..|:|:.:           :|.|.......||||....:|:....
Human   369 RARNRCLPMNFRAEDLASGILRERVKVGASLADVDPMNIDKSVRFDSIGGLSHHIHALKEMV--- 430

  Fly   243 RVFP---PELVEQLGIKHVKGILLYGPPGTGKTLMARQIGTMLNAREPKIV----NGPQILDKYV 300
             |||   ||:.|:..|:..:|.|.||||||||||:||.:....:..:.|:.    .|...|.|:|
Human   431 -VFPLLYPEIFEKFKIQPPRGCLFYGPPGTGKTLVARALANECSQGDKKVAFFMRKGADCLSKWV 494

  Fly   301 GESEANIRRLFAEAEEEEKRLGPNSGLHIIIFDEIDAICKARGSVAGNSGVHDTVVNQLLAKIDG 365
            ||||..:|.||.:|    ..:.|:    ||.|||||.:...|.|  ....:|.::|:.|||.:||
Human   495 GESERQLRLLFDQA----YLMRPS----IIFFDEIDGLAPVRSS--RQDQIHSSIVSTLLALMDG 549

  Fly   366 VEQLNNILVIGMTNRRDMIDEALLRPGRLEVQMEISLPNEQGRVQILNIHTKRMRDFNKIASDVD 430
            ::....|:|||.|||.|.||.||.||||.:.:...:||:::.|..||.|||   ||:|...||..
Human   550 LDNRGEIVVIGATNRLDSIDPALRRPGRFDREFLFNLPDQKARKHILQIHT---RDWNPKLSDAF 611

  Fly   431 NNEIAAKTKNFSGAELEGLVRAAQSTAMNR----LIKADSKVHVDPEAMEKLRVTRADFLHALDN 491
            ..|:|.|...:.||:::.|...|...|:.|    :..:..|:.:|   :..:.::..||.||:.|
Human   612 LGELAEKCVGYCGADIKALCTEAALIALRRRYPQIYASSHKLQLD---VSSIVLSAQDFYHAMQN 673

  Fly   492 DIKPAFGAA------------QEMLE----NLLARGIINWGPPVTE-------------LLED-- 525
             |.||...|            :.:||    |:||  ::....|..|             :|||
Human   674 -IVPASQRAVMSSGHALSPIIRPLLERSFNNILA--VLQKVFPHAEISQSDKKEDIETLILEDSE 735

  Fly   526 --GMLSVQQA-------KATESSGLV--------------------SVLIEGAPNSGKS-----A 556
              ..||:.:.       |...||..:                    .:|:.|...||::     |
Human   736 DENALSIFETNCHSGSPKKQSSSAAIHKPYLHFTMSPYHQPTSYRPRLLLSGERGSGQTSHLAPA 800

  Fly   557 LAANLAQLS----DFP---FVKVCSPEDMVGFTESAKCLHIRKIFDDAYRSTLSCIVVDNVERLL 614
            |...|.:.|    |.|   .|...:||:        .|   .:||.:|.|:..|.:
Human   801 LLHTLERFSVHRLDLPALYSVSAKTPEE--------SC---AQIFREARRTVPSIV--------- 845

  Fly   615 DYGP-IGPRYSNL--TLQALLVLLKKQPPKGRKLLILCTSSR--RDVLEEMEML--SAFTSVLHV 672
             |.| ||..:..:  |::|..:.|.:..|....:.:|.||..  .::.||::.:  ..:..||::
Human   846 -YMPHIGDWWEAVSETVRATFLTLLQDIPSFSPIFLLSTSETMYSELPEEVKCIFRIQYEEVLYI 909

  Fly   673 SNLSTPENVLAVLDDSDLFSPEELQSIARKMAGKR----LCIGIKKLLALIDMIRQSEPHQRVIK 733
            ..        .:.:|...|..|.:.:.|.....:|    ||     .:.::.:...|.|.|....
Human   910 QR--------PIEEDRRKFFQELILNQASMAPPRRKHAALC-----AMEVLPLALPSPPRQLSES 961

  Fly   734 FLSKMEEE 741
            ..|:||::
Human   962 EKSRMEDQ 969

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nsf2	NP_001287318.1	CDC48_N	9..89	CDD:215012
		CDC48_2	117..>170	CDD:215011
		AAA	259..404	CDD:214640	61/148 (41%)
		AAA	261..402	CDD:278434	59/144 (41%)
		AAA	543..674	CDD:214640	34/149 (23%)
		P-loop_NTPase	544..>613	CDD:304359	19/80 (24%)
ATAD2B	XP_011531220.1	AAA	447..588	CDD:214640	61/150 (41%)
		AAA	452..586	CDD:278434	59/143 (41%)
		COG5076	866..>1100	CDD:227408	22/117 (19%)
		Bromo_AAA	974..1085	CDD:99957
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810