DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nsf2 and PEX1

DIOPT Version :9

Sequence 1:	NP_001287318.1	Gene:	Nsf2 / 41694	FlyBaseID:	FBgn0266464	Length:	752	Species:	Drosophila melanogaster
Sequence 2:	NP_000457.1	Gene:	PEX1 / 5189	HGNCID:	8850	Length:	1283	Species:	Homo sapiens

Alignment Length:	438	Identity:	136/438 - (31%)
Similarity:	202/438 - (46%)	Gaps:	62/438 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   186 TVVQFEKAENSVLNLQGRSKGKIVRQSIINPDWDFGKMGIGGLDKEFNAIFRRAFASRVFPPELV 250
            |.:.|:||....|....||..       ::...|.|...|||| .|...|...........|||.
Human   810 TTLDFQKALRGFLPASLRSVN-------LHKPRDLGWDKIGGL-HEVRQILMDTIQLPAKYPELF 866

  Fly   251 EQLGIKHVKGILLYGPPGTGKTLMARQIGTMLNAREPKI----VNGPQILDKYVGESEANIRRLF 311
            ..|.|:...||||||||||||||:|..|     |||.::    |.||::|.||:|.||..:|.:|
Human   867 ANLPIRQRTGILLYGPPGTGKTLLAGVI-----ARESRMNFISVKGPELLSKYIGASEQAVRDIF 926

  Fly   312 AEAEEEEKRLGPNSGLHIIIFDEIDAICKARGSVAGNSGVHDTVVNQLLAKIDGVEQLNNILVIG 376
            ..|:..:.        .|:.|||.::|...||.  .|:||.|.||||||.::||||.|..:.|:.
Human   927 IRAQAAKP--------CILFFDEFESIAPRRGH--DNTGVTDRVVNQLLTQLDGVEGLQGVYVLA 981

  Fly   377 MTNRRDMIDEALLRPGRLEVQMEISLPNEQGRVQILNIHTKRMRDFNKIASDVDNNEIAAKTKNF 441
            .|:|.|:||.||||||||:..:....|::..|::|||:    :.|...:|.|||...:|:.|.:|
Human   982 ATSRPDLIDPALLRPGRLDKCVYCPPPDQVSRLEILNV----LSDSLPLADDVDLQHVASVTDSF 1042

  Fly   442 SGAELEGLVRAAQSTAMNRLIKADSKVHVDPEAMEKLRVTRADFL-HALDNDIKPAFG------- 498
            :||:|:.|:..||..|::.::.:.........:...|.::...|| |:..:|.....|
Human  1043 TGADLKALLYNAQLEALHGMLLSSGLQDGSSSSDSDLSLSSMVFLNHSSGSDDSAGDGECGLDQS 1107

  Fly   499 -AAQEMLENLLARGIIN-----WGPPVTELLEDGMLSVQQAKATESSGLVSVLIEGAPNSGKSAL 557
             .:.||.|.|......|     :|......|.:|..|...::...:...::..:.|.|  ||..|
Human  1108 LVSLEMSEILPDESKFNMYRLYFGSSYESELGNGTSSDLSSQCLSAPSSMTQDLPGVP--GKDQL 1170

  Fly   558 AANLAQLSDFPFVKVCSPEDMVGFTESAKCLHIRKIFDDAYRSTLSCI 605
                  .|..|.::..|.|.....|:..:         |..|:.:|.|
Human  1171 ------FSQPPVLRTASQEGCQELTQEQR---------DQLRADISII 1203

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nsf2	NP_001287318.1	CDC48_N	9..89	CDD:215012
		CDC48_2	117..>170	CDD:215011
		AAA	259..404	CDD:214640	67/148 (45%)
		AAA	261..402	CDD:278434	66/144 (46%)
		AAA	543..674	CDD:214640	14/63 (22%)
		P-loop_NTPase	544..>613	CDD:304359	14/62 (23%)
PEX1	NP_000457.1	PEX-2N	19..98	CDD:286362
		PEX-1N	104..179	CDD:286361
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	346..367
		SpoVK	595..1063	CDD:223540	107/279 (38%)
		AAA	595..731	CDD:278434
		AAA	877..1006	CDD:278434	66/143 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1260..1283
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810