DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nsf2 and Pex1

DIOPT Version :9

Sequence 1:	NP_001287318.1	Gene:	Nsf2 / 41694	FlyBaseID:	FBgn0266464	Length:	752	Species:	Drosophila melanogaster
Sequence 2:	NP_001102690.1	Gene:	Pex1 / 500006	RGDID:	1559939	Length:	1283	Species:	Rattus norvegicus

Alignment Length:	304	Identity:	113/304 - (37%)
Similarity:	163/304 - (53%)	Gaps:	35/304 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   165 RTVGDSLPKTRN-VRFGRILGNTVVQFEKAENSVLNLQGRSKGKIVRQSIINPDWDFGKMGIGGL 228
            |.:..||.:.:| .|.|..|  |...|:||      |:|.....:...::..|. |.|...||||
  Rat   790 RAIHSSLSRQQNPTREGLTL--TTADFQKA------LRGFLPASLRNVNLHKPR-DLGWDKIGGL 845

  Fly   229 DKEFNAIFRRAFASRVFPPELVEQLGIKHVKGILLYGPPGTGKTLMARQIGTMLNAREPKI---- 289
             .|...|...........|||...|.|:...||||||||||||||:|..:     |||..:
  Rat   846 -HEVRQILMDTIQLPAKYPELFANLPIRQRTGILLYGPPGTGKTLLAGVV-----ARESGMNFIS 904

  Fly   290 VNGPQILDKYVGESEANIRRLFAEAEEEEKRLGPNSGLHIIIFDEIDAICKARGSVAGNSGVHDT 354
            :.||::|.||:|.||..:|.:|..|:..:.        .|:.|||.::|...||.  .|:||.|.
  Rat   905 IQGPELLSKYIGASEQAVRDVFIRAQAAKP--------CILFFDEFESIAPRRGH--DNTGVTDR 959

  Fly   355 VVNQLLAKIDGVEQLNNILVIGMTNRRDMIDEALLRPGRLEVQMEISLPNEQGRVQILNIHTKRM 419
            ||||||.::||||.|..:.|:..|:|.|:||.||||||||:..:....|::..|::||.:.:|.:
  Rat   960 VVNQLLTQLDGVEGLQGVYVLAATSRPDLIDPALLRPGRLDKCVYCPPPDQVSRLEILTVLSKSL 1024

  Fly   420 RDFNKIASDVDNNEIAAKTKNFSGAELEGLVRAAQSTAM-NRLI 462
                .:|.|||...:|:.|::|:||:|:.|:..||..|: .||:
  Rat  1025 ----PLADDVDLQHVASVTESFTGADLKALLYNAQLEALQGRLL 1064

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nsf2	NP_001287318.1	CDC48_N	9..89	CDD:215012
		CDC48_2	117..>170	CDD:215011	1/4 (25%)
		AAA	259..404	CDD:214640	65/148 (44%)
		AAA	261..402	CDD:278434	64/144 (44%)
		AAA	543..674	CDD:214640
		P-loop_NTPase	544..>613	CDD:304359
Pex1	NP_001102690.1	PEX-2N	19..98	CDD:286362
		PEX-1N	104..179	CDD:286361
		AAA	591..741	CDD:214640
		AAA	595..724	CDD:278434
		AAA	877..1009	CDD:214640	64/146 (44%)
		AAA	877..1006	CDD:278434	64/143 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810