DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nsf2 and NSF

DIOPT Version :9

Sequence 1:	NP_001287318.1	Gene:	Nsf2 / 41694	FlyBaseID:	FBgn0266464	Length:	752	Species:	Drosophila melanogaster
Sequence 2:	NP_006169.2	Gene:	NSF / 4905	HGNCID:	8016	Length:	744	Species:	Homo sapiens

Alignment Length:	741	Identity:	470/741 - (63%)
Similarity:	585/741 - (78%)	Gaps:	6/741 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 MRAIKCPTDELSLTNKAIVNVSDFTEEVKYVDISPGPGLHYIFALEKISGPELPLGHVGFSLVQR 73
            |:|.:||||||||||.|:||..|| :..::|.:...|...|.|.|:  :.|.:..|.:.|||.||
Human     6 MQAARCPTDELSLTNCAVVNEKDF-QSGQHVIVRTSPNHRYTFTLK--THPSVVPGSIAFSLPQR 67

  Fly    74 KWATLSINQEIDVRPYRFDASADIITLVSFETDFLQKKTTTQEPYDSDEMAKEFLMQFAGMPLTV 138
            |||.|||.|||:|..|.||.:...|..::.|.||||||:....|||:|:||.||:.||.....:|
Human    68 KWAGLSIGQEIEVSLYTFDKAKQCIGTMTIEIDFLQKKSIDSNPYDTDKMAAEFIQQFNNQAFSV 132

  Fly   139 GQTLVFQFKDKKFLGLAVKTLEAVDPRTV-GD-SLPKTRNVRFGRILGNTVVQFEKAENSVLNLQ 201
            ||.|||.|.:|.| ||.||.:||:||..: |: :..|.:.:..|.::||:.|.|||||||.|||.
Human   133 GQQLVFSFNEKLF-GLLVKDIEAMDPSILKGEPATGKRQKIEVGLVVGNSQVAFEKAENSSLNLI 196

  Fly   202 GRSKGKIVRQSIINPDWDFGKMGIGGLDKEFNAIFRRAFASRVFPPELVEQLGIKHVKGILLYGP 266
            |::|.|..|||||||||:|.|||||||||||:.||||||||||||||:|||:|.|||||||||||
Human   197 GKAKTKENRQSIINPDWNFEKMGIGGLDKEFSDIFRRAFASRVFPPEIVEQMGCKHVKGILLYGP 261

  Fly   267 PGTGKTLMARQIGTMLNAREPKIVNGPQILDKYVGESEANIRRLFAEAEEEEKRLGPNSGLHIII 331
            ||.||||:|||||.||||||||:||||:||:|||||||||||:|||:||||::|||.||||||||
Human   262 PGCGKTLLARQIGKMLNAREPKVVNGPEILNKYVGESEANIRKLFADAEEEQRRLGANSGLHIII 326

  Fly   332 FDEIDAICKARGSVAGNSGVHDTVVNQLLAKIDGVEQLNNILVIGMTNRRDMIDEALLRPGRLEV 396
            |||||||||.|||:||::|||||||||||:|||||||||||||||||||.|:|||||||||||||
Human   327 FDEIDAICKQRGSMAGSTGVHDTVVNQLLSKIDGVEQLNNILVIGMTNRPDLIDEALLRPGRLEV 391

  Fly   397 QMEISLPNEQGRVQILNIHTKRMRDFNKIASDVDNNEIAAKTKNFSGAELEGLVRAAQSTAMNRL 461
            :|||.||:|:||:|||:|||.|||....:::|||..|:|.:|||||||||||||||||||||||.
Human   392 KMEIGLPDEKGRLQILHIHTARMRGHQLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRH 456

  Fly   462 IKADSKVHVDPEAMEKLRVTRADFLHALDNDIKPAFGAAQEMLENLLARGIINWGPPVTELLEDG 526
            |||.:||.||.|..|.|:|||.|||.:|:||||||||..||...:.:..|||.||.|||.:|:||
Human   457 IKASTKVEVDMEKAESLQVTRGDFLASLENDIKPAFGTNQEDYASYIMNGIIKWGDPVTRVLDDG 521

  Fly   527 MLSVQQAKATESSGLVSVLIEGAPNSGKSALAANLAQLSDFPFVKVCSPEDMVGFTESAKCLHIR 591
            .|.|||.|.::.:.|||||:||.|:|||:||||.:|:.|:|||:|:|||:.|:||:|:|||..::
Human   522 ELLVQQTKNSDRTPLVSVLLEGPPHSGKTALAAKIAEESNFPFIKICSPDKMIGFSETAKCQAMK 586

  Fly   592 KIFDDAYRSTLSCIVVDNVERLLDYGPIGPRYSNLTLQALLVLLKKQPPKGRKLLILCTSSRRDV 656
            |||||||:|.|||:|||::||||||.|||||:|||.||||||||||.||:||||||:.|:||:||
Human   587 KIFDDAYKSQLSCVVVDDIERLLDYVPIGPRFSNLVLQALLVLLKKAPPQGRKLLIIGTTSRKDV 651

  Fly   657 LEEMEMLSAFTSVLHVSNLSTPENVLAVLDDSDLFSPEELQSIARKMAGKRLCIGIKKLLALIDM 721
            |:|||||:||::.:||.|::|.|.:|..|:....|..:|..:||:::.||::.|||||||.||:|
Human   652 LQEMEMLNAFSTTIHVPNIATGEQLLEALELLGNFKDKERTTIAQQVKGKKVWIGIKKLLMLIEM 716

  Fly   722 IRQSEPHQRVIKFLSKMEEEGGLEMD 747
            ..|.:|..||.|||:.:.|||...:|
Human   717 SLQMDPEYRVRKFLALLREEGASPLD 742

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nsf2	NP_001287318.1	CDC48_N	9..89	CDD:215012	39/79 (49%)
		CDC48_2	117..>170	CDD:215011	28/54 (52%)
		AAA	259..404	CDD:214640	124/144 (86%)
		AAA	261..402	CDD:278434	121/140 (86%)
		AAA	543..674	CDD:214640	90/130 (69%)
		P-loop_NTPase	544..>613	CDD:304359	43/68 (63%)
NSF	NP_006169.2	CDC48_N	6..83	CDD:215012	39/79 (49%)
		CDC48_2	111..>159	CDD:308534	27/48 (56%)
		SpoVK	<142..490	CDD:223540	256/348 (74%)
		AAA	538..670	CDD:214640	90/131 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147774
Domainoid	1	1.000	247	1.000	Domainoid score	I2155
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4502
Inparanoid	1	1.050	907	1.000	Inparanoid score	I371
Isobase	1	0.950	-	0	Normalized mean entropy	S525
OMA	1	1.010	-	-		QHG52406
OrthoDB	1	1.010	-	-		D156590at33208
OrthoFinder	1	1.000	-	-		FOG0003053
OrthoInspector	1	1.000	-	-		otm40848
orthoMCL	1	0.900	-	-		OOG6_101440
Panther	1	1.100	-	-	LDO	PTHR23078
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2410
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.720