Protein Alignment Nsf2 and NSF

DIOPT Version :10

• Sequence 1: NP_788676.1
• Gene: Nsf2 / 41694
• FlyBaseID: FBgn0266464
• Length: 752
• Species: Drosophila melanogaster
• Sequence 2: NP_006169.2
• Gene: NSF / 4905
• HGNCID: 8016
• Length: 744
• Species: Homo sapiens
• Alignment Length: 741
• Identity: 470/741 - (63%)
• Similarity: 585/741 - (78%)
• Gaps: 6/741 - (0%)

  Fly     9 MRAIKCPTDELSLTNKAIVNVSDFTEEVKYVDISPGPGLHYIFALEKISGPELPLGHVGFSLVQR 73
            |:|.:||||||||||.|:||..|| :..::|.:...|...|.|.|:  :.|.:..|.:.|||.||
Human     6 MQAARCPTDELSLTNCAVVNEKDF-QSGQHVIVRTSPNHRYTFTLK--THPSVVPGSIAFSLPQR 67

  Fly    74 KWATLSINQEIDVRPYRFDASADIITLVSFETDFLQKKTTTQEPYDSDEMAKEFLMQFAGMPLTV 138
            |||.|||.|||:|..|.||.:...|..::.|.||||||:....|||:|:||.||:.||.....:|
Human    68 KWAGLSIGQEIEVSLYTFDKAKQCIGTMTIEIDFLQKKSIDSNPYDTDKMAAEFIQQFNNQAFSV 132

  Fly   139 GQTLVFQFKDKKFLGLAVKTLEAVDPRTV-GD-SLPKTRNVRFGRILGNTVVQFEKAENSVLNLQ 201
            ||.|||.|.:|.| ||.||.:||:||..: |: :..|.:.:..|.::||:.|.|||||||.|||.
Human   133 GQQLVFSFNEKLF-GLLVKDIEAMDPSILKGEPATGKRQKIEVGLVVGNSQVAFEKAENSSLNLI 196

  Fly   202 GRSKGKIVRQSIINPDWDFGKMGIGGLDKEFNAIFRRAFASRVFPPELVEQLGIKHVKGILLYGP 266
            |::|.|..|||||||||:|.|||||||||||:.||||||||||||||:|||:|.|||||||||||
Human   197 GKAKTKENRQSIINPDWNFEKMGIGGLDKEFSDIFRRAFASRVFPPEIVEQMGCKHVKGILLYGP 261

  Fly   267 PGTGKTLMARQIGTMLNAREPKIVNGPQILDKYVGESEANIRRLFAEAEEEEKRLGPNSGLHIII 331
            ||.||||:|||||.||||||||:||||:||:|||||||||||:|||:||||::|||.||||||||
Human   262 PGCGKTLLARQIGKMLNAREPKVVNGPEILNKYVGESEANIRKLFADAEEEQRRLGANSGLHIII 326

  Fly   332 FDEIDAICKARGSVAGNSGVHDTVVNQLLAKIDGVEQLNNILVIGMTNRRDMIDEALLRPGRLEV 396
            |||||||||.|||:||::|||||||||||:|||||||||||||||||||.|:|||||||||||||
Human   327 FDEIDAICKQRGSMAGSTGVHDTVVNQLLSKIDGVEQLNNILVIGMTNRPDLIDEALLRPGRLEV 391

  Fly   397 QMEISLPNEQGRVQILNIHTKRMRDFNKIASDVDNNEIAAKTKNFSGAELEGLVRAAQSTAMNRL 461
            :|||.||:|:||:|||:|||.|||....:::|||..|:|.:|||||||||||||||||||||||.
Human   392 KMEIGLPDEKGRLQILHIHTARMRGHQLLSADVDIKELAVETKNFSGAELEGLVRAAQSTAMNRH 456

  Fly   462 IKADSKVHVDPEAMEKLRVTRADFLHALDNDIKPAFGAAQEMLENLLARGIINWGPPVTELLEDG 526
            |||.:||.||.|..|.|:|||.|||.:|:||||||||..||...:.:..|||.||.|||.:|:||
Human   457 IKASTKVEVDMEKAESLQVTRGDFLASLENDIKPAFGTNQEDYASYIMNGIIKWGDPVTRVLDDG 521

  Fly   527 MLSVQQAKATESSGLVSVLIEGAPNSGKSALAANLAQLSDFPFVKVCSPEDMVGFTESAKCLHIR 591
            .|.|||.|.::.:.|||||:||.|:|||:||||.:|:.|:|||:|:|||:.|:||:|:|||..::
Human   522 ELLVQQTKNSDRTPLVSVLLEGPPHSGKTALAAKIAEESNFPFIKICSPDKMIGFSETAKCQAMK 586

  Fly   592 KIFDDAYRSTLSCIVVDNVERLLDYGPIGPRYSNLTLQALLVLLKKQPPKGRKLLILCTSSRRDV 656
            |||||||:|.|||:|||::||||||.|||||:|||.||||||||||.||:||||||:.|:||:||
Human   587 KIFDDAYKSQLSCVVVDDIERLLDYVPIGPRFSNLVLQALLVLLKKAPPQGRKLLIIGTTSRKDV 651

  Fly   657 LEEMEMLSAFTSVLHVSNLSTPENVLAVLDDSDLFSPEELQSIARKMAGKRLCIGIKKLLALIDM 721
            |:|||||:||::.:||.|::|.|.:|..|:....|..:|..:||:::.||::.|||||||.||:|
Human   652 LQEMEMLNAFSTTIHVPNIATGEQLLEALELLGNFKDKERTTIAQQVKGKKVWIGIKKLLMLIEM 716

  Fly   722 IRQSEPHQRVIKFLSKMEEEGGLEMD 747
            ..|.:|..||.|||:.:.|||...:|
Human   717 SLQMDPEYRVRKFLALLREEGASPLD 742

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nsf2	NP_788676.1	CDC48_N	9..89	CDD:215012	39/79 (49%)
		CDC48_2	117..>170	CDD:215011	28/54 (52%)
		RecA-like_NSF-SEC18_r1-like	224..400	CDD:410912	151/175 (86%)
		CDC48	<225..>611	CDD:273521	282/385 (73%)
NSF	NP_006169.2	CDC48_N	6..83	CDD:215012	39/79 (49%)
		CDC48_2	111..183	CDD:215011	32/72 (44%)
		CDC48	159..>606	CDD:273521	314/446 (70%)
		RecA-like_NSF-SEC18_r1-like	219..395	CDD:410912	151/175 (86%)