DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nsf2 and spast

DIOPT Version :9

Sequence 1:	NP_001287318.1	Gene:	Nsf2 / 41694	FlyBaseID:	FBgn0266464	Length:	752	Species:	Drosophila melanogaster
Sequence 2:	NP_998080.2	Gene:	spast / 405851	ZFINID:	ZDB-GENE-040426-2331	Length:	570	Species:	Danio rerio

Alignment Length:	510	Identity:	131/510 - (25%)
Similarity:	216/510 - (42%)	Gaps:	123/510 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 EKAHRMRAIKCPTDELSLTNKAIVNVSDFTEEVKYVD--ISPGPG------LHYIFALEKISGPE 60
            |||.|.|         .|.:|.|.|:|...:.:|.:.  :|..|.      ..|.|:    :|..
Zfish   132 EKADRAR---------KLQDKMITNLSMAEDRLKLLGNLLSQSPAESSSDDSFYSFS----NGNL 183

  Fly    61 LPLGHVGFSLVQRKWATLSINQEIDVRPYRFDASADIITLVSFETDFLQKKTTTQEPYDSDEMAK 125
            .|....|  .|.:|..||:|..:..:||.....|....:.::......|...|  .|.::.:
Zfish   184 RPAPASG--AVSKKKDTLTITNQTSLRPKNPPKSTPNASGLNCTPSAAQSSRT--GPQNNQK--- 241

  Fly   126 EFLMQFAGMPLTVGQTLVFQFKDKKFLGLAVKTLEAVDPRTVGDSLPKTRNVRFGRILGNTVVQF 190
                                       |..||....|...|...:.|:.:     |.:.|    |
Zfish   242 ---------------------------GPTVKGKNNVKASTTATASPQRK-----RDMKN----F 270

  Fly   191 EKAENSVLNLQGRSKGKIVRQSIINPDWDFGKM----GIGGLDKEFNAIFRRAFASRVFPPELVE 251
            :..::.:.:|            |:|...|.|.:    .|.|.|     :.::|....|..|.|..
Zfish   271 KNVDSKLASL------------ILNEIVDSGSVVRFDDIAGQD-----LAKQALQEIVILPALRP 318

  Fly   252 QL--GIK-HVKGILLYGPPGTGKTLMARQIGTMLNAREPKIVNGPQILDKYVGESEANIRRLFAE 313
            :|  |:: ..:|:||:||||.|||::|:.:....||....| :...:..|||||.|..:|.|||.
Zfish   319 ELFTGLRAPARGLLLFGPPGNGKTMLAKAVAMESNATFFNI-SAATLTSKYVGEGEKLVRALFAV 382

  Fly   314 AEEEEKRLGPNSGLHIIIFDEIDA-ICKARGSVAGNSGVHDT---VVNQLLAKIDGVEQLNN--I 372
            |.|    |.|:    ||..||||: :|:.|      .|.||.   :..:.|.:.|||:...:  :
Zfish   383 ARE----LQPS----IIFIDEIDSLLCERR------EGEHDASRRLKTEFLIEFDGVQSGGDERV 433

  Fly   373 LVIGMTNRRDMIDEALLRPGRLEVQMEISLPNEQGRVQIL-NIHTKRMRDFNKIASDVDNNEIAA 436
            ||:|.|||...:|||:||  |...::.::||.|:.|:::| |:.:|.....    |..:.:::|.
Zfish   434 LVMGATNRPQELDEAVLR--RFAKRIYVALPTEETRLKLLKNLLSKHRNPL----SQKELSQLAR 492

  Fly   437 KTKNFSGAELEGLVRAAQSTAMN--RLIKADSKVHVDPEAMEKLRVTRADFLHAL 489
            .|..:||::|..|   |:..|:.  |.:|.:...::....|..:|:  :|||.:|
Zfish   493 LTDGYSGSDLTSL---AKDAALGPIRELKPEQVRNMSAHEMRDIRI--SDFLESL 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nsf2	NP_001287318.1	CDC48_N	9..89	CDD:215012	20/87 (23%)
		CDC48_2	117..>170	CDD:215011	6/52 (12%)
		AAA	259..404	CDD:214640	56/150 (37%)
		AAA	261..402	CDD:278434	54/146 (37%)
		AAA	543..674	CDD:214640
		P-loop_NTPase	544..>613	CDD:304359
spast	NP_998080.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	186..269		19/121 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900