DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nsf2 and nsfa

DIOPT Version :9

Sequence 1:	NP_001287318.1	Gene:	Nsf2 / 41694	FlyBaseID:	FBgn0266464	Length:	752	Species:	Drosophila melanogaster
Sequence 2:	XP_021325418.1	Gene:	nsfa / 368483	ZFINID:	ZDB-GENE-030616-37	Length:	747	Species:	Danio rerio

Alignment Length:	739	Identity:	462/739 - (62%)
Similarity:	577/739 - (78%)	Gaps:	6/739 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 MRAIKCPTDELSLTNKAIVNVSDFTEEVKYVDISPGPGLHYIFALEKISGPELPLGHVGFSLVQR 73
            |:|.:||||||||||.|:|:..|. :..::|.:...|...::|.: |.....|| |.:.|||.||
Zfish     6 MQAARCPTDELSLTNCAVVSEKDL-QSGQHVTVRTTPTHKFVFTV-KGHHSVLP-GTIAFSLPQR 67

  Fly    74 KWATLSINQEIDVRPYRFDASADIITLVSFETDFLQKKTTTQEPYDSDEMAKEFLMQFAGMPLTV 138
            |||.|||.|||:|..|.||.|...|..::.|.||||||:|...|||||:||.||:..|.....:|
Zfish    68 KWAGLSIGQEIEVSNYNFDKSRQCIGAMTIEIDFLQKKSTDSSPYDSDKMAAEFIQHFNNQSFSV 132

  Fly   139 GQTLVFQFKDKKFLGLAVKTLEAVDPRTV-GD-SLPKTRNVRFGRILGNTVVQFEKAENSVLNLQ 201
            ||.|||.|.||.| ||.:|.:||:|...: |: :..|.:.:..|.::||:.|.|||:|:|.|.|.
Zfish   133 GQQLVFSFCDKLF-GLLIKDIEAMDSSILKGEPASGKKQKIEVGLLVGNSQVIFEKSESSSLTLV 196

  Fly   202 GRSKGKIVRQSIINPDWDFGKMGIGGLDKEFNAIFRRAFASRVFPPELVEQLGIKHVKGILLYGP 266
            |::|.|..||:||||||:|.|||||||||||:.|||||||||||||::|||:|.||||||||:||
Zfish   197 GKAKTKEARQTIINPDWNFEKMGIGGLDKEFSDIFRRAFASRVFPPDIVEQMGCKHVKGILLFGP 261

  Fly   267 PGTGKTLMARQIGTMLNAREPKIVNGPQILDKYVGESEANIRRLFAEAEEEEKRLGPNSGLHIII 331
            ||.||||||||||.|||||||||||||:||:|||||||||||:|||:||||:||||.||||||||
Zfish   262 PGCGKTLMARQIGKMLNAREPKIVNGPEILNKYVGESEANIRKLFADAEEEQKRLGANSGLHIII 326

  Fly   332 FDEIDAICKARGSVAGNSGVHDTVVNQLLAKIDGVEQLNNILVIGMTNRRDMIDEALLRPGRLEV 396
            |||:|||||.||:.|.::|||||||||||:|||||||||||||||||||.|:|||||:||||.||
Zfish   327 FDELDAICKQRGTGASSTGVHDTVVNQLLSKIDGVEQLNNILVIGMTNRPDLIDEALMRPGRFEV 391

  Fly   397 QMEISLPNEQGRVQILNIHTKRMRDFNKIASDVDNNEIAAKTKNFSGAELEGLVRAAQSTAMNRL 461
            :|||.||:|:||||||||||.:||:|..:|||||..|:||:|||:|||||||||||||||||||.
Zfish   392 KMEIGLPDEKGRVQILNIHTAKMREFKLLASDVDVKELAAETKNYSGAELEGLVRAAQSTAMNRH 456

  Fly   462 IKADSKVHVDPEAMEKLRVTRADFLHALDNDIKPAFGAAQEMLENLLARGIINWGPPVTELLEDG 526
            |||.|.|.||.|..|||:|||.||:.:|:||||||||..||...:.:..|||.||.|||.:||||
Zfish   457 IKATSTVEVDMERAEKLQVTRTDFMASLNNDIKPAFGTNQEDYSSYIMNGIIKWGDPVTRVLEDG 521

  Fly   527 MLSVQQAKATESSGLVSVLIEGAPNSGKSALAANLAQLSDFPFVKVCSPEDMVGFTESAKCLHIR 591
            .|.|||.|.::.:.|||||:||.|:|||:||||.:::.|.|||:|:|||:.|:|.:|.:||..|:
Zfish   522 ELLVQQTKNSDRTPLVSVLLEGPPHSGKTALAAKISEDSQFPFIKICSPDKMIGHSEISKCQAIK 586

  Fly   592 KIFDDAYRSTLSCIVVDNVERLLDYGPIGPRYSNLTLQALLVLLKKQPPKGRKLLILCTSSRRDV 656
            |||||||:|.|||:|||::||||||.|||||:|||.||||||||||.||.||||||:.|:||:||
Zfish   587 KIFDDAYKSQLSCVVVDDIERLLDYVPIGPRFSNLVLQALLVLLKKTPPHGRKLLIIGTTSRKDV 651

  Fly   657 LEEMEMLSAFTSVLHVSNLSTPENVLAVLDDSDLFSPEELQSIARKMAGKRLCIGIKKLLALIDM 721
            |:|||||.||::.:||.|:|:.::::..|:....|:..|..:||:.:.|||:.|||||||.||:|
Zfish   652 LQEMEMLDAFSTTIHVQNISSGDHLVEALELLGSFTDAERTTIAQHVKGKRVWIGIKKLLMLIEM 716

  Fly   722 IRQSEPHQRVIKFLSKMEEEGGLE 745
            ..|.:...||.||||.:::||.|:
Zfish   717 SLQMDQEYRVSKFLSLLKDEGALD 740

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nsf2	NP_001287318.1	CDC48_N	9..89	CDD:215012	37/79 (47%)
		CDC48_2	117..>170	CDD:215011	27/54 (50%)
		AAA	259..404	CDD:214640	121/144 (84%)
		AAA	261..402	CDD:278434	118/140 (84%)
		AAA	543..674	CDD:214640	88/130 (68%)
		P-loop_NTPase	544..>613	CDD:304359	41/68 (60%)
nsfa	XP_021325418.1	CDC48_N	6..83	CDD:215012	37/79 (47%)
		CDC48_2	111..183	CDD:215011	31/72 (43%)
		TIP49	160..>606	CDD:332389	309/445 (69%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581612
Domainoid	1	1.000	250	1.000	Domainoid score	I2069
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4502
Inparanoid	1	1.050	891	1.000	Inparanoid score	I373
OMA	1	1.010	-	-		QHG52406
OrthoDB	1	1.010	-	-		D156590at33208
OrthoFinder	1	1.000	-	-		FOG0003053
OrthoInspector	1	1.000	-	-		mtm6536
orthoMCL	1	0.900	-	-		OOG6_101440
Panther	1	1.100	-	-	LDO	PTHR23078
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1308
SonicParanoid	1	1.000	-	-		X2410
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800