DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nsf2 and Spast

DIOPT Version :9

Sequence 1:	NP_001287318.1	Gene:	Nsf2 / 41694	FlyBaseID:	FBgn0266464	Length:	752	Species:	Drosophila melanogaster
Sequence 2:	XP_008762708.1	Gene:	Spast / 362700	RGDID:	1308494	Length:	614	Species:	Rattus norvegicus

Alignment Length:	344	Identity:	104/344 - (30%)
Similarity:	164/344 - (47%)	Gaps:	70/344 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   165 RTVGDSLPKTRNVRFGRILGNTVVQFEKAENSVLNLQGRSKGKIVRQSIINPDWDFGKM----GI 225
            ||...|.|.|. ||..:.|.|    |...::::.||            |:|...|.|..    .|
  Rat   295 RTNKPSTPTTA-VRKKKDLKN----FRNVDSNLANL------------IMNEIVDNGTAVKFDDI 342

  Fly   226 GGLDKEFNAIFRRAFASRVFPPELVEQL--GIK-HVKGILLYGPPGTGKTLMARQIGTMLNAREP 287
            .|.:     :.::|....|..|.|..:|  |:: ..:|:||:||||.|||::|:.:....||...
  Rat   343 AGQE-----LAKQALQEIVILPSLRPELFTGLRAPARGLLLFGPPGNGKTMLAKAVAAESNATFF 402

  Fly   288 KIVNGPQILDKYVGESEANIRRLFAEAEEEEKRLGPNSGLHIIIFDEIDA-ICKARGSVAGNSGV 351
            .| :...:..|||||.|..:|.|||.|.|    |.|:    ||..||:|: :|:.|      .|.
  Rat   403 NI-SAASLTSKYVGEGEKLVRALFAVARE----LQPS----IIFIDEVDSLLCERR------EGE 452

  Fly   352 HDT---VVNQLLAKIDGVEQL--NNILVIGMTNRRDMIDEALLRPGRLEVQMEISLPNEQGRVQI 411
            ||.   :..:.|.:.|||:..  :.:||:|.|||...:|||:||  |...::.:|||||:.|:.:
  Rat   453 HDASRRLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLR--RFIKRVYVSLPNEETRLLL 515

  Fly   412 L-NIHTKRMRDFNKIASDVDNNE---IAAKTKNFSGAELEGLVRAAQSTAMN--RLIKADSKVHV 470
            | |:..|:       .|.:...|   :|..|..:||::|..|   |:..|:.  |.:|.:...::
  Rat   516 LKNLLCKQ-------GSPLTQKELAQLARMTDGYSGSDLTAL---AKDAALGPIRELKPEQVKNM 570

  Fly   471 DPEAMEKLRVTRADFLHAL 489
            ....|..:|:  :||..:|
  Rat   571 SASEMRNIRL--SDFTESL 587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nsf2	NP_001287318.1	CDC48_N	9..89	CDD:215012
		CDC48_2	117..>170	CDD:215011	2/4 (50%)
		AAA	259..404	CDD:214640	56/150 (37%)
		AAA	261..402	CDD:278434	53/146 (36%)
		AAA	543..674	CDD:214640
		P-loop_NTPase	544..>613	CDD:304359
Spast	XP_008762708.1	MIT_spastin	114..193	CDD:239142
		P-loop_NTPase	339..>395	CDD:304359	19/60 (32%)
		AAA	372..508	CDD:214640	56/152 (37%)
		AAA	376..506	CDD:278434	53/146 (36%)
		Vps4_C	<578..610	CDD:286426	4/12 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900