DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nsf2 and TER94

DIOPT Version :9

Sequence 1:	NP_001287318.1	Gene:	Nsf2 / 41694	FlyBaseID:	FBgn0266464	Length:	752	Species:	Drosophila melanogaster
Sequence 2:	NP_001097249.1	Gene:	TER94 / 36040	FlyBaseID:	FBgn0286784	Length:	826	Species:	Drosophila melanogaster

Alignment Length:	688	Identity:	184/688 - (26%)
Similarity:	292/688 - (42%)	Gaps:	177/688 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 CPTDELSLT----NKAIVNVSDFTEEVKYVDISPGPGLHYIFALEKISGPELPLGHVGFSLVQRK 74
            ||.:::.:.    |...|::||      .|.:...|.:.|
  Fly    99 CPDEKIRMNRVVRNNLCVHLSD------VVSVQSCPDVKY------------------------- 132

  Fly    75 WATLSINQEIDVRPYRFDASADIITLVSFETDFLQKKTTTQEPYDSDEMAKEFLMQFAGMPLTVG 139
                  .:.:.:.|  .|.|.:.:|...||   :..|....|.|....|...|:::.|..|:
  Fly   133 ------GKRVRILP--IDESTEGVTGNLFE---IYLKPYFLEAYRPIHMGDNFIVRAAMRPI--- 183

  Fly   140 QTLVFQFKDKKFLGLAVKTLEAVDPRTVGDSLPKTRNVRFGRILGNTVVQFEKAENSVLNLQGRS 204
                 :||           :...||.......|:|  |.|  ..|:.:.:.|:.|:  ||..|
  Fly   184 -----EFK-----------VVLTDPEPYCIVAPET--VIF--CDGDPIKREEEEES--LNAVG-- 224

  Fly   205 KGKIVRQSIINPDWDFGKMGIGGLDKEFNAIFRRAFASRVFPPELVEQLGIKHVKGILLYGPPGT 269
                         :|    .|||..|:. |..:......:..|.|.:.:|:|..:|||:||||||
  Fly   225 -------------YD----DIGGCRKQL-AQIKEMVELPLRHPSLFKAIGVKPPRGILMYGPPGT 271

  Fly   270 GKTLMARQIGTMLNAREPK----IVNGPQILDKYVGESEANIRRLFAEAEEEEKRLGPNSGLHII 330
            ||||:||.:     |.|..    ::|||:|:.|..||||:|:|:.|.|||:....        ||
  Fly   272 GKTLIARAV-----ANETGAFFFLINGPEIMSKLAGESESNLRKAFEEAEKNSPA--------II 323

  Fly   331 IFDEIDAICKARGSVAGNSGVHDTVVNQLLAKIDGVEQLNNILVIGMTNRRDMIDEALLRPGRLE 395
            ..||||||...|....|.  |...:|:|||..:||:::.::::|:..|||.:.||.||.|.||.:
  Fly   324 FIDEIDAIAPKRDKTHGE--VERRIVSQLLTLMDGMKKSSHLIVMAATNRPNSIDPALRRFGRFD 386

  Fly   396 VQMEISLPNEQGRVQILNIHTKRMRDFNKIASDVDNNEIAAKTKNFSGAELEGLVRAAQ----ST 456
            .:::|.:|:..||:::|.||||.|    |:..|||..:|||::....||:|..|...|.    ..
  Fly   387 REIDIGIPDATGRLEVLRIHTKNM----KLHDDVDLEQIAAESHGHVGADLASLCSEAALQQIRE 447

  Fly   457 AMNRLIKADSKVHVDPEAMEKLRVTRADFLHALDNDIKPAFGAAQEMLENLLARGIINWGPPVTE 521
            .|:.:...|.|  :|.|.:..|.||..:|.:|:   .|.:..|.:|.:..:         |..|.
  Fly   448 KMDLIDLEDDK--IDAEVLASLAVTMENFRYAM---TKSSPSALRETVVEV---------PNTTW 498

  Fly   522 LLEDGMLSVQQAKATESSGLV-------------------SVLIEGAPNSGKSALAANLAQLSDF 567
            ....|:.||::    |...||                   .||..|.|..||:.||..:|.....
  Fly   499 TDIGGLESVKK----ELQELVQYPVEHPDKFLKFGMQPSRGVLFYGPPGCGKTLLAKAIANECQA 559

  Fly   568 PFVKVCSPEDM-VGFTESAKCLHIRKIFDDAYRSTLSCIV----VDNVER-----LLDYGPIGPR 622
            .|:.|..||.: :.|.||.  .::|.|||.| ||...|::    :|::.:     :.|.|....|
  Fly   560 NFISVKGPELLTMWFGESE--ANVRDIFDKA-RSAAPCVLFFDELDSIAKARGGNVGDAGGAADR 621

  Fly   623 YSNLTLQALLVLLKKQPPKGRK--LLILCTSSRRDVLE 658
            ..|       .:|.:....|.|  :.|:..::|.|:::
  Fly   622 VIN-------QILTEMDGMGAKKNVFIIGATNRPDIID 652

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nsf2	NP_001287318.1	CDC48_N	9..89	CDD:215012	9/78 (12%)
		CDC48_2	117..>170	CDD:215011	9/52 (17%)
		AAA	259..404	CDD:214640	61/148 (41%)
		AAA	261..402	CDD:278434	60/144 (42%)
		AAA	543..674	CDD:214640	35/128 (27%)
		P-loop_NTPase	544..>613	CDD:304359	25/78 (32%)
TER94	NP_001097249.1	CDC48	47..787	CDD:273521	184/688 (27%)
		CDC48_N	47..129	CDD:280513	7/35 (20%)
		CDC48_2	153..213	CDD:215011	18/85 (21%)
		AAA	263..392	CDD:278434	59/143 (41%)
		AAA	536..669	CDD:278434	35/127 (28%)
		Vps4_C	<741..783	CDD:286426
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810