DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nsf2 and Nvl

DIOPT Version :9

Sequence 1:	NP_001287318.1	Gene:	Nsf2 / 41694	FlyBaseID:	FBgn0266464	Length:	752	Species:	Drosophila melanogaster
Sequence 2:	NP_001099450.1	Gene:	Nvl / 289323	RGDID:	1311270	Length:	855	Species:	Rattus norvegicus

Alignment Length:	827	Identity:	199/827 - (24%)
Similarity:	342/827 - (41%)	Gaps:	184/827 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSIEKAHR-MRAIKCPTDELSLTNKAIVNVSD-FTEEVKYVDISPGPGLHYIFALEKISGPELPL 63
            :|.||.|: ::.:    ::..|..:|..:..| :||.....|.:          :|....|: ..
  Rat    66 ISSEKEHKNLKEL----EDGHLAKRARQDEDDEYTESYSDDDSN----------MEDYPDPQ-SA 115

  Fly    64 GHVGFSLVQ--RKWATLSINQEIDVRPYRFDASADIITLVSFETDFLQKKTTTQEPYDSDEMAKE 126
            .|:..||:.  ||..:.|::....:. .|.||::.  .|:|.:||.:..||..:||.....:.|.
  Rat   116 NHMNSSLLSLYRKGNSDSVSTTPKLE-QREDATSS--PLLSSKTDSMPLKTPAREPEGGWFIDKT 177

  Fly   127 FLMQFAGMPLTVGQTLVFQFKDKKFLGLAVKTLEAVDP--RTVGD-SLPKTRNVRFGRILG---- 184
            ...|...:||.:...   |...||           .||  :.:.| ||.::...|..|..|
  Rat   178 PGGQKESLPLDLSDD---QSNCKK-----------QDPGIQNLKDSSLLESDKKRKSRAKGKGNK 228

  Fly   185 NTVVQFEKAENSV-LNLQGRSKGKIVRQSIINPDWDFGKMGIGGLDKEFNAIFRRAFASRVFPPE 248
            ......::|:..: ..||.|:|.|.....|.:..::    .:||.|.....:.:.....|  .||
  Rat   229 RKTEGLQEADGEIEAILQKRAKAKSTELQISSVKFE----DVGGNDATLKEVCKMLIHMR--HPE 287

  Fly   249 LVEQLGIKHVKGILLYGPPGTGKTLMARQIGTMLNAREPKIVNGPQILDKYVGESEANIRRLFAE 313
            :.:.||:...:|:||:||||.||||:|..|...|:....|:. .|:|:....||||..:|.||.:
  Rat   288 VYQHLGVVPPRGVLLHGPPGCGKTLLAHAIAGELDLPILKVA-APEIVSGVSGESEQKLRDLFDQ 351

  Fly   314 AEEEEKRLGPNSGLHIIIFDEIDAICKARGSVAGNSGVHDTVVNQLLAKIDGVEQLNN------I 372
            |        .::...|:..||||||...| .|| :..:...:|.|||..:|   .|||      :
  Rat   352 A--------VSNAPCIVFIDEIDAITPKR-EVA-SKDMERRIVAQLLTCMD---DLNNVAATARV 403

  Fly   373 LVIGMTNRRDMIDEALLRPGRLEVQMEISLPNEQGRVQILNIHTKRMRDFNKIASDVDNNEIAAK 437
            ||:|.|||.|.:|.||.|.||.:.::.:.:|:|..|.:||....:::|    :....:.:.:|..
  Rat   404 LVVGATNRPDSLDPALRRAGRFDREVCLGIPDEASRERILQTLCRKLR----LPETFNFSHLAHL 464

  Fly   438 TKNFSGAELEGLVRAAQSTAMNR-LIKADSKVHVDPEA--------------------------- 474
            |..|.||:|..|.|.|...|::| |::...:...:||.
  Rat   465 TPGFVGADLMALCREAAVCAVHRVLMRRQEQQRTEPETGGLPSDGEQGRSLGAEPPSETQDELQR 529

  Fly   475 ---------------MEKLRVTRADFLHALDNDIKPAFGAAQEMLENLLARGIINWG-----PPV 519
                           |:.|.:...||:.|| ::::|:     ...|..:....:.|.     ..:
  Rat   530 LLGLLRDQDPISEEQMQGLCLELNDFIVAL-SEVQPS-----AKREGFVTVPNVTWADVGALEDI 588

  Fly   520 TELLEDGMLS-VQQAKATESSGLVS---VLIEGAPNSGKSALAANLAQLSDFPFVKVCSPEDM-- 578
            .|.|...:|: |:..:...:.|||:   ||:.|.|..||:.||..:|..|...|:.|..||.:
  Rat   589 REELTMAILAPVRNPEQFRALGLVAPAGVLLAGPPGCGKTLLAKAVANESGLNFISVKGPELLNM 653

  Fly   579 -VGFTESAKCLHIRKIFDDAYRSTLSCIVVDNVERLLDYGPIGPRYSN----LTLQALLVLLKKQ 638
             ||.:|.|    :|::|..|..|....|..|.|:.|.      ||.|:    .:::.:..||.:.
  Rat   654 YVGESERA----VRQVFQRAKNSAPCVIFFDEVDALC------PRRSDRETGASVRVVNQLLTEM 708

  Fly   639 P--PKGRKLLILCTSSRRDVLEEMEMLSAFTSVLHVSNLSTPENVLAVL-------------DDS 688
            .  ...:::.||..::|.|:::...:............|..|.:.:|:|             :|.
  Rat   709 DGLETRQQVFILAATNRPDIIDPAILRPGRLDKTLFVGLPPPADRVAILKTITKNGTKPPLDEDV 773

  Fly   689 DL-----------FSPEELQSIAR---------KMAGKRLCIGIKKL 715
            ||           ::..:|.::.|         ::.|::..||..:|
  Rat   774 DLEAIANDHRCDCYTGADLSALVREASLCALRQEITGQKNGIGTAEL 820

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nsf2	NP_001287318.1	CDC48_N	9..89	CDD:215012	14/82 (17%)
		CDC48_2	117..>170	CDD:215011	11/55 (20%)
		AAA	259..404	CDD:214640	56/150 (37%)
		AAA	261..402	CDD:278434	55/146 (38%)
		AAA	543..674	CDD:214640	35/142 (25%)
		P-loop_NTPase	544..>613	CDD:304359	25/71 (35%)
Nvl	NP_001099450.1	Nucleolin_bd	2..71	CDD:406995	2/4 (50%)
Nvl	NP_001099450.1	CDC48	<255..855	CDD:273521	149/606 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900