DRSC/TRiP Functional Genomics Resources

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Protein Alignment Nsf2 and Vcp

DIOPT Version :9

Sequence 1:NP_001287318.1 Gene:Nsf2 / 41694 FlyBaseID:FBgn0266464 Length:752 Species:Drosophila melanogaster
Sequence 2:NP_033529.3 Gene:Vcp / 269523 MGIID:99919 Length:806 Species:Mus musculus


Alignment Length:616 Identity:176/616 - (28%)
Similarity:278/616 - (45%) Gaps:133/616 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   175 RNVRFGRIL----GNTVVQFEKAE-----------NSVLNLQGRSKGKIVRQSIINPDWDFGKMG 224
            |.:|.|.|.    |...|:|:..|           ::|::.:|....:...:..:|   :.|...
Mouse   144 RPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLN---EVGYDD 205

  Fly   225 IGGLDKEFNAIFRRAFASRVFPPELVEQLGIKHVKGILLYGPPGTGKTLMARQIGTMLNAREPK- 288
            |||..|:. |..:......:..|.|.:.:|:|..:||||||||||||||:||.:     |.|.. 
Mouse   206 IGGCRKQL-AQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAV-----ANETGA 264

  Fly   289 ---IVNGPQILDKYVGESEANIRRLFAEAEEEEKRLGPNSGLHIIIFDEIDAICKARGSVAGNSG 350
               ::|||:|:.|..||||:|:|:.|.|||:....        ||..||:|||...|....|.  
Mouse   265 FFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPA--------IIFIDELDAIAPKREKTHGE-- 319

  Fly   351 VHDTVVNQLLAKIDGVEQLNNILVIGMTNRRDMIDEALLRPGRLEVQMEISLPNEQGRVQILNIH 415
            |...:|:|||..:||::|..:::|:..|||.:.||.||.|.||.:.:::|.:|:..||::||.||
Mouse   320 VERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIH 384

  Fly   416 TKRMRDFNKIASDVDNNEIAAKTKNFSGAELEGLVRAAQSTAMNR---LIKADSKVHVDPEAMEK 477
            ||.|    |:|.|||..::|.:|....||:|..|...|...|:.:   ||..:.:. :|.|.|..
Mouse   385 TKNM----KLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDET-IDAEVMNS 444

  Fly   478 LRVTRADFLHALDNDIKPA---------------FGAAQEMLENLLARGIINWGPPV---TELLE 524
            |.||..||..||......|               .|..:::...|  :.::.:  ||   .:.|:
Mouse   445 LAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKREL--QELVQY--PVEHPDKFLK 505

  Fly   525 DGMLSVQQAKATESSGLVSVLIEGAPNSGKSALAANLAQLSDFPFVKVCSPEDM-VGFTESAKCL 588
            .||        |.|.|   ||..|.|..||:.||..:|......|:.:..||.: :.|.||.  .
Mouse   506 FGM--------TPSKG---VLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESE--A 557

  Fly   589 HIRKIFDDAYRSTLSCIV----VDNVER-----LLDYGPIGPRYSNLTLQALLVLLKKQPPKGRK 644
            ::|:|||.| |....|::    :|::.:     :.|.|....|..|                   
Mouse   558 NVREIFDKA-RQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVIN------------------- 602

  Fly   645 LLILCTSSRRDVLEEMEMLSAFTSVLHVSNLSTPENVLAVLDDSDLFSPEEL-QSIARKMAGKRL 708
                      .:|.||:.:|...:|..:...:.|:.:     |..:..|..| |.|...:..::.
Mouse   603 ----------QILTEMDGMSTKKNVFIIGATNRPDII-----DPAILRPGRLDQLIYIPLPDEKS 652

  Fly   709 CIGIKKLLALIDMIRQSEPHQRV-IKFLSKM 738
            .:.|.|.     .:|:|...:.| ::||:||
Mouse   653 RVAILKA-----NLRKSPVAKDVDLEFLAKM 678

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Nsf2NP_001287318.1 CDC48_N 9..89 CDD:215012
CDC48_2 117..>170 CDD:215011
AAA 259..404 CDD:214640 62/148 (42%)
AAA 261..402 CDD:278434 61/144 (42%)
AAA 543..674 CDD:214640 32/140 (23%)
P-loop_NTPase 544..>613 CDD:304359 23/78 (29%)
VcpNP_033529.3 CDC48 25..764 CDD:273521 176/616 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 708..727
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 768..806
Interaction with UBXN6. /evidence=ECO:0000250 797..806
PIM motif. /evidence=ECO:0000250|UniProtKB:P55072 802..806
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0464
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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