Protein Alignment Nsf2 and Vcp

DIOPT Version :10

• Sequence 1: NP_788676.1
• Gene: Nsf2 / 41694
• FlyBaseID: FBgn0266464
• Length: 752
• Species: Drosophila melanogaster
• Sequence 2: NP_033529.3
• Gene: Vcp / 269523
• MGIID: 99919
• Length: 806
• Species: Mus musculus
• Alignment Length: 616
• Identity: 176/616 - (28%)
• Similarity: 278/616 - (45%)
• Gaps: 133/616 - (21%)

  Fly   175 RNVRFGRIL----GNTVVQFEKAE-----------NSVLNLQGRSKGKIVRQSIINPDWDFGKMG 224
            |.:|.|.|.    |...|:|:..|           ::|::.:|....:...:..:|   :.|...
Mouse   144 RPIRKGDIFLVRGGMRAVEFKVVETDPSPYCIVAPDTVIHCEGEPIKREDEEESLN---EVGYDD 205

  Fly   225 IGGLDKEFNAIFRRAFASRVFPPELVEQLGIKHVKGILLYGPPGTGKTLMARQIGTMLNAREPK- 288
            |||..|:. |..:......:..|.|.:.:|:|..:||||||||||||||:||.:     |.|..
Mouse   206 IGGCRKQL-AQIKEMVELPLRHPALFKAIGVKPPRGILLYGPPGTGKTLIARAV-----ANETGA 264

  Fly   289 ---IVNGPQILDKYVGESEANIRRLFAEAEEEEKRLGPNSGLHIIIFDEIDAICKARGSVAGNSG 350
               ::|||:|:.|..||||:|:|:.|.|||:....        ||..||:|||...|....|.
Mouse   265 FFFLINGPEIMSKLAGESESNLRKAFEEAEKNAPA--------IIFIDELDAIAPKREKTHGE-- 319

  Fly   351 VHDTVVNQLLAKIDGVEQLNNILVIGMTNRRDMIDEALLRPGRLEVQMEISLPNEQGRVQILNIH 415
            |...:|:|||..:||::|..:::|:..|||.:.||.||.|.||.:.:::|.:|:..||::||.||
Mouse   320 VERRIVSQLLTLMDGLKQRAHVIVMAATNRPNSIDPALRRFGRFDREVDIGIPDATGRLEILQIH 384

  Fly   416 TKRMRDFNKIASDVDNNEIAAKTKNFSGAELEGLVRAAQSTAMNR---LIKADSKVHVDPEAMEK 477
            ||.|    |:|.|||..::|.:|....||:|..|...|...|:.:   ||..:.:. :|.|.|..
Mouse   385 TKNM----KLADDVDLEQVANETHGHVGADLAALCSEAALQAIRKKMDLIDLEDET-IDAEVMNS 444

  Fly   478 LRVTRADFLHALDNDIKPA---------------FGAAQEMLENLLARGIINWGPPV---TELLE 524
            |.||..||..||......|               .|..:::...|  :.::.:  ||   .:.|:
Mouse   445 LAVTMDDFRWALSQSNPSALRETVVEVPQVTWEDIGGLEDVKREL--QELVQY--PVEHPDKFLK 505

  Fly   525 DGMLSVQQAKATESSGLVSVLIEGAPNSGKSALAANLAQLSDFPFVKVCSPEDM-VGFTESAKCL 588
            .||        |.|.|   ||..|.|..||:.||..:|......|:.:..||.: :.|.||.  .
Mouse   506 FGM--------TPSKG---VLFYGPPGCGKTLLAKAIANECQANFISIKGPELLTMWFGESE--A 557

  Fly   589 HIRKIFDDAYRSTLSCIV----VDNVER-----LLDYGPIGPRYSNLTLQALLVLLKKQPPKGRK 644
            ::|:|||.| |....|::    :|::.:     :.|.|....|..|
Mouse   558 NVREIFDKA-RQAAPCVLFFDELDSIAKARGGNIGDGGGAADRVIN------------------- 602

  Fly   645 LLILCTSSRRDVLEEMEMLSAFTSVLHVSNLSTPENVLAVLDDSDLFSPEEL-QSIARKMAGKRL 708
                      .:|.||:.:|...:|..:...:.|:.:     |..:..|..| |.|...:..::.
Mouse   603 ----------QILTEMDGMSTKKNVFIIGATNRPDII-----DPAILRPGRLDQLIYIPLPDEKS 652

  Fly   709 CIGIKKLLALIDMIRQSEPHQRV-IKFLSKM 738
            .:.|.|.     .:|:|...:.| ::||:||
Mouse   653 RVAILKA-----NLRKSPVAKDVDLEFLAKM 678

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nsf2	NP_788676.1	CDC48_N	9..89	CDD:215012
		CDC48_2	117..>170	CDD:215011
		RecA-like_NSF-SEC18_r1-like	224..400	CDD:410912	70/179 (39%)
		CDC48	<225..>611	CDD:273521	140/415 (34%)
Vcp	NP_033529.3	CDC48	25..764	CDD:273521	176/616 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	708..727
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	768..806
		Interaction with UBXN6. /evidence=ECO:0000250	797..806
		PIM motif. /evidence=ECO:0000250|UniProtKB:P55072	802..806