DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nsf2 and Iqca1l

DIOPT Version :9

Sequence 1:	NP_001287318.1	Gene:	Nsf2 / 41694	FlyBaseID:	FBgn0266464	Length:	752	Species:	Drosophila melanogaster
Sequence 2:	NP_808344.3	Gene:	Iqca1l / 231045	MGIID:	3045319	Length:	825	Species:	Mus musculus

Alignment Length:	721	Identity:	135/721 - (18%)
Similarity:	250/721 - (34%)	Gaps:	198/721 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 RFDASADIITLVSFETDFLQKKTTTQEPYDSDEMAKEFLMQFAGMPLTVGQTLVFQFKDKKFLGL 154
            :|......|.:......:||:|...|:        :...|:|.||..:..||......::.|||.
Mouse   203 KFSRDQGAIVIQKVWKGYLQRKRIEQD--------RRVEMEFIGMLPSPNQTARLNTLNQAFLGE 259

  Fly   155 AVKTLEAVDPRTVGDSLPKTRNVRFGRILGNTVVQFEKAENSVLNLQGRSKGKIVRQSIIN---- 215
            ..:.:..|:           :...|...:|.|.....:.|..  :::.|.|.:| ||..|.
Mouse   260 ESRRMRQVE-----------KEEEFQEAIGKTYESLTETEGP--DMKERMKDQI-RQWFIECHAL 310

  Fly   216 ----PDWDFGKMGIGGLDKEFNAIFRRAFASRVFPPELVEQLGIKHVKGILLYGPPGTGKTLMAR 276
                ||:.....|...|               :|..:..||:.:                .|.|:
Mouse   311 TGRFPDYPDEASGGSYL---------------IFADKTPEQVRL----------------DLEAQ 344

  Fly   277 QIGTMLNAREPKIVNGPQILDKYVGESEANIRRLFAEAEEEEK----RLGPNSGLHIIIFDEIDA 337
            ...:....:|.|..|    .:|...:.|...:::..|..::|.    |:.|:..:.:|
Mouse   345 AQESRKKDQEKKEKN----KEKEKEKKEKKKKKVKEEKVKKEPEVMFRVLPSKSIPVI------- 398

  Fly   338 ICKARGSVAGNSGVHDTVVNQLLAKIDGVEQLNNILVIGMTNRRDMIDEALLRPGRLEVQMEISL 402
                      |:| |:...:...::.|......|           ...|.|....|.:|:|||
Mouse   399 ----------NAG-HEEYTSVWKSRYDNKHPSQN-----------FDSETLREEKRKQVEMEI-- 439

  Fly   403 PNEQGRVQILNIHTKRMRDFNKIASDVDNNEI-AAKTKNFSGAELEGLVRAAQSTAMNRLIKADS 466
                 |||:..:..:.:::. ::|  ||..|. ..|:....|.:..|..:..:....:|.:.:..
Mouse   440 -----RVQVDELMRQELKNL-RLA--VDREETRPLKSPKKKGGKKSGKKKKEKDLTPDRSVDSLF 496

  Fly   467 KVHVDPEAMEK-LRVTRADFLH---------ALDNDIKPAFGAAQEMLENLLARGIINWGPPVTE 521
            :..|....::| ..||.:|::.         .|.|  |....:..::.:|:...|::..|.....
Mouse   497 EELVIIGLIKKSALVTLSDYIGDCLYLGSTLTLAN--KMPMPSLFDIRQNMALYGVLRLGSHDIH 559

  Fly   522 LLEDGMLSVQQAKATESSGLV-SVLIEGAPNSGKSAL--------AANLAQLSDFPFVKVCSPED 577
            .:               :.|| |:|:.|....||..|        .|||..|         ||::
Mouse   560 TM---------------APLVRSILLVGPSGMGKKMLVQAVCTETGANLFDL---------SPDN 600

  Fly   578 MVG---FTESAKCL-HIRKIFDDAYRSTLSCIVVDNVERLLDYGPIGPRYSNLTLQAL---LVLL 635
            ::|   ....|:.| ||  :|..|.....|.|.:.|.|:.. |..:......:..:.:   |:..
Mouse   601 LMGKYPGKNGAQLLVHI--VFKVARLLQPSVIWIGNTEKTF-YKKVPKEERTMDPKRIKKDLMRA 662

  Fly   636 KKQPPKGRKLLILCTSSRRDVLEEMEMLSAFTSVLHVS----------------------NLSTP 678
            .||...|.:::::.|:.|..:.|...:...:..:|.:.                      .|::.
Mouse   663 TKQLSPGDRVMLIGTTERPQLAEMKGLCRFYERILFIPRPDYASRYVLWKRMIESQGRGVQLTSS 727

  Fly   679 ENVLAVLDDSDLFSPEE-LQSIARKMAGKRLCIGIKKLLA---LIDMIRQSEPHQRVIKFLSKME 739
            .:|.|:...||.::|.. ||||...:..:||...|||.|.   .:..:.:.:|..|        |
Mouse   728 LDVSALARVSDGYTPSHILQSIQSVLTERRLLQLIKKPLVASEFVGHLARLDPVYR--------E 784

  Fly   740 EEGGLE 745
            ||..|:
Mouse   785 EEESLK 790

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nsf2	NP_001287318.1	CDC48_N	9..89	CDD:215012
		CDC48_2	117..>170	CDD:215011	10/52 (19%)
		AAA	259..404	CDD:214640	24/148 (16%)
		AAA	261..402	CDD:278434	24/144 (17%)
		AAA	543..674	CDD:214640	32/167 (19%)
		P-loop_NTPase	544..>613	CDD:304359	22/80 (28%)
Iqca1l	NP_808344.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	344..378		5/37 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	459..487		5/27 (19%)
		SpoVK	<566..745	CDD:223540	38/190 (20%)
		AAA	568..701	CDD:278434	31/144 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900