DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nsf2 and figl-1

DIOPT Version :9

Sequence 1:	NP_001287318.1	Gene:	Nsf2 / 41694	FlyBaseID:	FBgn0266464	Length:	752	Species:	Drosophila melanogaster
Sequence 2:	NP_504197.1	Gene:	figl-1 / 178829	WormBaseID:	WBGene00017981	Length:	594	Species:	Caenorhabditis elegans

Alignment Length:	359	Identity:	100/359 - (27%)
Similarity:	155/359 - (43%)	Gaps:	92/359 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   147 KDKKFLGL-AVKTLEAVDPRTVGDSLPKTRNVRFGRILGNTVVQFEKAENSVLNLQGRSKGKIVR 210
            ||:|..|| |..||:..|...:  ||.::..:.....:|..         .|..|:|..|.  :|
Worm   278 KDEKMSGLRAEPTLKHFDENII--SLIESEIMSVNNEIGWA---------DVAGLEGAKKA--LR 329

  Fly   211 QSIINPDWDFGKMGIGGLDKEFNAIFRR--AFASRVFPPELVEQLGIKHVKGILLYGPPGTGKTL 273
            :.::.|                   |:|  .|.....||           ||:||:||||||||:
Worm   330 EIVVLP-------------------FKRPDVFTGIRAPP-----------KGVLLFGPPGTGKTM 364

  Fly   274 MARQIGTMLNAREPKIVNGPQILDKYVGESEANIRRLFAEAEEEEKRLGPNSGLHIIIFDEIDAI 338
            :.|.:.:...|....| :...:..|:|||.|..:|.||:.|     ||...|   :|..||||::
Worm   365 IGRCVASQCKATFFNI-SASSLTSKWVGEGEKLVRALFSVA-----RLKLPS---VIFIDEIDSL 420

  Fly   339 CKARGSVAGNSGVHDT---VVNQLLAKIDGVEQL--NNILVIGMTNRRDMIDEALLRPGRLEVQM 398
            ..:|     :...|::   :..:.|.::|||...  ..:||:|.|||...:|||..|  |.:.::
Worm   421 LSSR-----SESEHESSRRIKTEFLVQLDGVNTAPDERLLVLGATNRPQELDEAARR--RFQKRL 478

  Fly   399 EISLPNEQGRVQI---LNIHTKRMRDFNKIASDVDNN---EIAAKTKNFSGAELEGLVRAAQSTA 457
            .|:||..:.|.||   |.:.|:.         |:.|:   .|...|..:|||::..|...|   |
Worm   479 YIALPEPESRTQIVQNLLVGTRH---------DITNHNLERIRELTDGYSGADMRQLCTEA---A 531

  Fly   458 MNRLIKADSKVHVDPEAMEK--LR-VTRADFLHA 488
            |..:    ..:..|.|.::|  :| ||..||..|
Worm   532 MGPI----RDIGDDIETIDKDDIRAVTVMDFAEA 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nsf2	NP_001287318.1	CDC48_N	9..89	CDD:215012
		CDC48_2	117..>170	CDD:215011	9/23 (39%)
		AAA	259..404	CDD:214640	51/149 (34%)
		AAA	261..402	CDD:278434	48/145 (33%)
		AAA	543..674	CDD:214640
		P-loop_NTPase	544..>613	CDD:304359
figl-1	NP_504197.1	P-loop_NTPase	315..>371	CDD:304359	24/96 (25%)
		AAA	348..484	CDD:214640	53/162 (33%)
		AAA	352..480	CDD:278434	47/143 (33%)
		Vps4_C	<545..585	CDD:286426	7/17 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900