Protein Alignment Nsf2 and AFG2A

DIOPT Version :10

• Sequence 1: NP_788676.1
• Gene: Nsf2 / 41694
• FlyBaseID: FBgn0266464
• Length: 752
• Species: Drosophila melanogaster
• Sequence 2: NP_001425251.1
• Gene: AFG2A / 166378
• HGNCID: 18119
• Length: 917
• Species: Homo sapiens
• Alignment Length: 602
• Identity: 165/602 - (27%)
• Similarity: 271/602 - (45%)
• Gaps: 124/602 - (20%)

  Fly   225 IGGLDKEFNAIFRRAFASRVFPPELVEQLGIKHVKGILLYGPPGTGKTLMARQIGTMLNAREPKI 289
            ||||..:..|| |......:..|||.:..||...:|:|||||||||||::||.:...:.| ...:
Human   355 IGGLSSQLKAI-REIIELPLKQPELFKSYGIPAPRGVLLYGPPGTGKTMIARAVANEVGA-YVSV 417

  Fly   290 VNGPQILDKYVGESEANIRRLFAEAEEEEKRLGPNSGLHIIIFDEIDAICKARGSVAGNSGVHDT 354
            :|||:|:.|:.||:||.:|::||||....    |:    ||..||:||:|..|  ....:.|...
Human   418 INGPEIISKFYGETEAKLRQIFAEATLRH----PS----IIFIDELDALCPKR--EGAQNEVEKR 472

  Fly   355 VVNQLLAKIDGV---EQLNNILVIGMTNRRDMIDEALLRPGRLEVQMEISLPNEQGRVQILNIHT 416
            ||..||..:||:   .....:||:|.|||...:|.||.||||.:.::||.:||.|.|:.||.
Human   473 VVASLLTLMDGIGSEVSEGQVLVLGATNRPHALDAALRRPGRFDKEIEIGVPNAQDRLDILQ--- 534

  Fly   417 KRMRDFNKIASDVDNNEIAAKTKNFSGAELEGLVRAAQST------------------------A 457
            |.:|....:.::.:..::|.....:.||:|:.|...|..|                        |
Human   535 KLLRRVPHLLTEAELLQLANSAHGYVGADLKVLCNEAAGTRILKAHMYVSAFATGLTQTPQGLCA 599

  Fly   458 MNRLIKADSKVHVDPEAMEKLRVTRADFLHALDNDIKPAFGAAQEMLENLLARGIINWGPPVTEL 522
            :.|::|....: .|.:....:::|..|||.|: |||:|:     .|.|..:....::|    :::
Human   600 LRRILKKQPNL-PDVKVAGLVKITLKDFLQAM-NDIRPS-----AMREIAIDVPNVSW----SDI 653

  Fly   523 --LEDGMLSVQQA-----KATES---SGL---VSVLIEGAPNSGKSALAANLAQLSDFPFVKVCS 574
              ||...|.::||     |..||   .|:   ..||:.|.|...|:.:|..||..|...|:.:..
Human   654 GGLESIKLKLEQAVEWPLKHPESFIRMGIQPPKGVLLYGPPGCSKTMIAKALANESGLNFLAIKG 718

  Fly   575 PEDM---VGFTESAKCLHIRKIFDDAYRSTLSCIVVDNVERL-LDYG-PIGPRYSNLTLQALLVL 634
            ||.|   ||.:|.|    :|:.|..|.....|.|..|.::.| ::.| .:|.  .|:..:.|..|
Human   719 PELMNKYVGESERA----VRETFRKARAVAPSIIFFDELDALAVERGSSLGA--GNVADRVLAQL 777

  Fly   635 LKKQP--PKGRKLLILCTSSRRDVLEEMEM-------------------LSAFTSVLHVSNLSTP 678
            |.:..  .:.:.:.||..::|.|.:::..|                   ...|....|...:|..
Human   778 LTEMDGIEQLKDVTILAATNRPDRIDKALMRPGRIDRIIYVPLPDAATRREIFKLQFHSMPVSNE 842

  Fly   679 ENVLAVLDDSDLFSPEELQSIARKMAGKRLCIGIKKLLALIDMIRQS---EPH------------ 728
            .::..::..:|.:|..|:.::.|:.|          ||||.:.|:.:   :.|
Human   843 VDLDELILQTDAYSGAEIVAVCREAA----------LLALEEDIQANLIMKRHFTQALSTVTPRI 897

  Fly   729 -QRVIKFLSKMEEEGGL 744
             :.:.:|....:|:.||
Human   898 PESLRRFYEDYQEKSGL 914

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nsf2	NP_788676.1	CDC48_N	9..89	CDD:215012
		CDC48_2	117..>170	CDD:215011
		RecA-like_NSF-SEC18_r1-like	224..400	CDD:410912	70/177 (40%)
		CDC48	<225..>611	CDD:273521	135/428 (32%)
AFG2A	NP_001425251.1	None