DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9297 and HMGN5

DIOPT Version :9

Sequence 1:	NP_001262553.1	Gene:	CG9297 / 41688	FlyBaseID:	FBgn0038181	Length:	952	Species:	Drosophila melanogaster
Sequence 2:	NP_110390.1	Gene:	HMGN5 / 79366	HGNCID:	8013	Length:	282	Species:	Homo sapiens

Alignment Length:	364	Identity:	84/364 - (23%)
Similarity:	143/364 - (39%)	Gaps:	95/364 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 GSGELQSDQPRGDDDDDDDDGGHSAVDEKDTIEIETVELDSTEDAKSANDLDGDGIPDDEDDDID 118
            |.|:::.:..|       .....||:....|.|::.....|:...|:.:|:      .:|:.|..
Human     8 GQGDMRQEPKR-------RSARLSAMLVPVTPEVKPKRTSSSRKMKTKSDM------MEENIDTS 59

  Fly   119 GDGIPNEKDDDIDGDGIPNDEDDDIDGDGIPNEDDDDIDGDGVPNSKDEDIDGDGVPNSKDEDID 183
            ...:...|.:.:                         ::.|...|:|:.:......|.|:.|.:
Human    60 AQAVAETKQEAV-------------------------VEEDYNENAKNGEAKITEAPASEKEIV- 98

  Fly   184 GDGKANHEDDDLDGDGTPNHEDEDLDGDGVPNEEDDDLDGDGKINHEDEDLD-GDGVKNDEDEDL 247
             :.|..:.:|..:..|    |.::.....|.|||:|.     |.:.||::.: |:..|.|:||..
Human    99 -EVKEENIEDATEKGG----EKKEAVAAEVKNEEEDQ-----KEDEEDQNEEKGEAGKEDKDEKG 153

  Fly   248 DGDGKVNHEDEDLDGDGVKNEKDDDLDGDGTNNSQDEDLDGDGVPNEKDDDLDG-DGILNEHDGD 311
            :.|||     ||.:|    |||.:|                   ..||:|...| ||..|..||.
Human   154 EEDGK-----EDKNG----NEKGED-------------------AKEKEDGKKGEDGKGNGEDGK 190

  Fly   312 VDGDGVPNEHDHKDSGENADDDDDDDDEDDKEA----VKKRSKREVDAAPVLDIEAPPSPAEEFP 372
            ..|:....|.|.|::|:..:::|..:..|.||.    ||:..|...|..     |......||..
Human   191 EKGEDEKEEEDRKETGDGKENEDGKEKGDKKEGKDVKVKEDEKEREDGK-----EDEGGNEEEAG 250

  Fly   373 VEEEIVKEASAEEEAEVEAVKEEEPEQEAVQEPEPEPVV 411
            .|:|.:||  .||..|.:.:||::.::|     ||:.:|
Human   251 KEKEDLKE--EEEGKEEDEIKEDDGKKE-----EPQSIV 282

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9297	NP_001262553.1	TSP3 repeat_long	167..205	CDD:275366	6/37 (16%)
		EHD_N	539..569	CDD:293485
		EHD	574..813	CDD:206740
HMGN5	NP_110390.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..282		83/362 (23%)
		HMG14_17	1..93	CDD:307310	17/122 (14%)
		Na_Ca_ex	<61..281	CDD:332332	71/295 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S11722
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.950