Protein Alignment CG9297 and SRL

DIOPT Version :10

• Sequence 1: NP_788674.1
• Gene: CG9297 / 41688
• FlyBaseID: FBgn0038181
• Length: 952
• Species: Drosophila melanogaster
• Sequence 2: NP_001422369.1
• Gene: SRL / 6345
• HGNCID: 11295
• Length: 857
• Species: Homo sapiens
• Alignment Length: 920
• Identity: 295/920 - (32%)
• Similarity: 445/920 - (48%)
• Gaps: 161/920 - (17%)

  Fly    54 GSGELQSDQPRGDDD-----DDDDDGGHSAVDEKD-TIEIETVELDS------------------ 94
            |..|||.....|.:|     ::....|.::::||: .:..:|...|.
Human    18 GQAELQVSASGGTEDVGNLLENHFSAGDASLEEKERALYADTAPQDKKLLLHYPDGREAESPKKT 82

  Fly    95 ---------TEDAKSANDLDGDGIPDDEDDDIDGDGIPNEKDDDIDGDGIPNDEDDDIDGDGIPN 150
                     ..:|..:|....:..|..|.||.|..|...||:.......:|.      .|...|.
Human    83 PASAASAGPDPEASLSNASATESPPPGERDDRDAAGPGEEKNGPPVASALPP------GGAKGPV 141

  Fly   151 EDD--DDIDGDGVPNSKDEDIDGDGVPNSKDEDIDGDGKANHEDDDLDGDGTPNHEDEDLDGDGV 213
            |::  :...|:|    :.|:..|.|:|.        :|.|:.|.....|......|.:::.||.:
Human   142 EEEWPEPSSGEG----QGEEETGFGLPT--------EGTASGEAGGQAGGHELPEEVQEVQGDSL 194

  Fly   214 ----------PNEEDDDLDGDGKINHEDEDLDGDGVKNDEDEDLDGDGKVNHEDEDLDGDGVKNE 268
                      |..|       |...|.    :||||           |.:|.|.|...|.|
Human   195 VQGAVAGTAEPKAE-------GASPHS----EGDGV-----------GPLNAEAEGSPGPG---- 233

  Fly   269 KDDDLDGDGTNNSQDEDLDGDGVPNEKDDDLDGDGILNEHDGDVDGDGVPNEHDHKDSGENADDD 333
                          :|....:|.|       |...:..|.:.|:|........|..:.|..|:
Human   234 --------------EEPAVPEGAP-------DVAAVGGESEPDIDTQASEGTEDQGEPGPAAE-- 275

  Fly   334 DDDDDEDDKEAVKKRSKREVDAAPVLDIEAPPSPAEEFPVEEEIVKEASAEEEAEVEAVKEEE-- 396
                     .:.:....:.|.|.   |.|...||    .:.||...|||:|||:...:..|||
Human   276 ---------ASAEPGGAQSVKAG---DTEENQSP----EMTEEDADEASSEEESGDGSGSEEEGG 324

  Fly   397 -PEQEAVQEPEPEPVVEPEAEVQPEPVQQEEEKAESAEAKEEEKPAPVEEAEAEEESVQPEAA-- 458
             |.:|..:|...:.....|||...|...:.:|..|..||:|.::...::|||..:|...|:.|
Human   325 VPSEEESEEDSGDGASSEEAEGASEEATEPQEAGEPQEAREPQEGGDLQEAEESQEGGDPQEAEE 389

  Fly   459 PKEPEAVQEEAQEDEPQTDGAQDAADDDDDTKPEDELLWEGHIPENRRSRQHITELLQLDEEFNA 523
            |:|..|.||..:..|.:|:.|.:.|.                    .|.|.||.:.|.|:|
Human   390 PQEGGAPQEGGEPQEEETEDANEEAP--------------------LRDRSHIEKTLMLNE---- 430

  Fly   524 REKATDNVAEIILRDIKRIYENAVKPLETLYKYRDLSNRHFSDPEIFSKPLILFMGPWSGGKSSI 588
             :|.:|:.:.::.| :::||.:::||||..|||.:|.....:|.||.|||::||:||||.|||::
Human   431 -DKPSDDYSAVLQR-LRKIYHSSIKPLEQSYKYNELRQHEITDGEITSKPMVLFLGPWSVGKSTM 493

  Fly   589 LNYLTDNEYTPNSLRTGAEPSPAYFNILMWGNETEVLDGTQLAAD--YTFAGLQKFGQGLEERLR 651
            :|||...|.|...|.|||||:.:.|.:||.|.:.:.::|..:|||  .:|:.|:||||...|:|.
Human   494 INYLLGLENTRYQLYTGAEPTTSEFTVLMHGPKLKTIEGIVMAADSARSFSPLEKFGQNFLEKLI 558

  Fly   652 GLKMKSKILEKVNIVEIPGILEVRKQVSRVFPFNDACQWFIDRADIIFLVYDPAKLDVGPETEAI 716
            |:::..|:||:|..|:.|||:|.|||..|.:||||.|||||||||:||:|:||.|||||.|.|.:
Human   559 GIEVPHKLLERVTFVDTPGIIENRKQQERGYPFNDVCQWFIDRADLIFVVFDPTKLDVGLELEML 623

  Fly   717 LDQLKGREYQTRIILNKADTVKPEELLRVQGALIWNISPLMSSAQPPLMYTTSLWTHPYQDGAPA 781
            ..||||||.|.||||||||.:..:.|:||.|||.|:::||::..:||.:|.:|.|...|:.....
Human   624 FRQLKGRESQIRIILNKADNLATQMLMRVYGALFWSLAPLINVTEPPRVYVSSFWPQEYKPDTHQ 688

  Fly   782 RLLLAQERAFLRDLRTAIDKRIEHKIASARRFAVRVRNHAKMVDCYLNTFNNHKTLFGNKKRIAD 846
            .|.|.:|.:.|.||...|:.|:|:|||..|:.|:|||.||.:||.||.|:.:..|.|.:.:.:..
Human   689 ELFLQEEISLLEDLNQVIENRLENKIAFIRQHAIRVRIHALLVDRYLQTYKDKMTFFSDGELVFK 753

  Fly   847 DIIDHPQNYHIYEGLSTLTNISRYDLPDPEVYRDFFRLNPLYEFKKLRDTCTYFRGCPITKLDLA 911
            ||::.|..::|::.:...||:|::|||:.|.|:|||.:||:..||.|...|:|..||.:.|::.|
Human   754 DIVEDPDKFYIFKTILAKTNVSKFDLPNREAYKDFFGINPISSFKLLSQQCSYMGGCFLEKIERA 818

  Fly   912 IAYELPELAG 921
            |..|||.|.|
Human   819 ITQELPGLLG 828

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG9297	NP_788674.1	MSCRAMM_ClfA	<93..367	CDD:468110	56/312 (18%)
		TSP3 repeat_long	167..205	CDD:275366	8/37 (22%)
		EHD_N	539..570	CDD:465295	12/30 (40%)
		EHD	574..813	CDD:206740	118/240 (49%)
SRL	NP_001422369.1	PRK07764	<71..389	CDD:236090	86/400 (22%)
		EHD_N	443..475	CDD:465295	13/32 (41%)
		EHD	479..720	CDD:206740	118/240 (49%)