DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9297 and ehd3

DIOPT Version :9

Sequence 1:	NP_001262553.1	Gene:	CG9297 / 41688	FlyBaseID:	FBgn0038181	Length:	952	Species:	Drosophila melanogaster
Sequence 2:	NP_001038469.1	Gene:	ehd3 / 562949	ZFINID:	ZDB-GENE-041014-352	Length:	535	Species:	Danio rerio

Alignment Length:	409	Identity:	112/409 - (27%)
Similarity:	206/409 - (50%)	Gaps:	38/409 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   524 REKATDNVAEIILRDIKRIYENAVKPLETLYKYRDLSNRHFSDPEIFSKPLILFMGPWSGGKSSI 588
            |.|....|.:.:...:|::|:..:.|||..||:.:..:....|.:..:||::|.:|.:|.||:|.
Zfish    10 RRKKDPEVFQTVSEGLKKLYKTKLLPLEEHYKFHEFHSPALEDADFDNKPMVLLVGQYSTGKTSF 74

  Fly   589 LNYLTDNEYTPNSLRTGAEPSPAYFNILMWGNETEVLDGTQLAAD--YTFAGLQKFGQGLEERLR 651
            :.||.:.::.  .:|.|.||:...|..:|.|....::.|..|..|  ..|..|..||.....|..
Zfish    75 IRYLLEQDFP--GMRIGPEPTTDSFIAVMHGTMEGLIPGNALVVDPKKPFRKLNAFGNAFLNRFV 137

  Fly   652 GLKMKSKILEKVNIVEIPGILEVRKQ-VSRVFPFNDACQWFIDRADIIFLVYDPAKLDVGPETEA 715
            ..::.:.:||.:::::.||||...|| :||.:.|....:||.:|.|.|.|::|..|||:..|...
Zfish   138 CAQLPNPVLESISVIDTPGILSGEKQRISRGYDFAAVLEWFAERVDRIILLFDAHKLDISDEFSE 202

  Fly   716 ILDQLKGREYQTRIILNKADTVKPEELLRVQGALIWNISPLMSSAQPPLMYTTSLWTHPYQDGAP 780
            ::..||..|.:.|::|||||.::.::|:||.|||:|::..::::.:...:|..|.|:||......
Zfish   203 VIKALKNHEDKIRVVLNKADQIETQQLMRVYGALMWSLGKIVNTPEVIRVYIGSFWSHPLLIPDN 267

  Fly   781 ARLLLAQERAFLRDL----RTAIDKRIEHKIASARRFAVRVRNHAKMVDCYLNTFNNHKTLFG-- 839
            .:|..|:|:...:|:    |.|..:::...|..||...|    ||.::.   :......::||
Zfish   268 RKLFEAEEQDLFKDIQSLPRNAALRKLNDLIKRARLAKV----HAYIIS---SLKKEMPSVFGKD 325

  Fly   840 NKKRIADDIIDHPQNYHIYEGLSTLTNISRYDLPDPEVYRDFFRLNPLYEFK----KLRDTCTYF 900
            |||:   ::|:  ....||..:.....||..|.|:.:..::..:.:.|.:|:    ||.||
Zfish   326 NKKK---ELIN--SLGEIYSRIEREHQISPGDFPNLKKMQEQLQAHDLNKFQPLKMKLLDT---- 381

  Fly   901 RGCPITKLDLAIAYELPEL 919
                   :|..:|:::.:|
Zfish   382 -------VDDMLAHDIAQL 393

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9297	NP_001262553.1	TSP3 repeat_long	167..205	CDD:275366
		EHD_N	539..569	CDD:293485	8/29 (28%)
		EHD	574..813	CDD:206740	75/245 (31%)
ehd3	NP_001038469.1	EHD_N	<37..56	CDD:293485	4/18 (22%)
		EHD	60..300	CDD:206740	73/241 (30%)
		EH	438..531	CDD:197477
		EH	448..513	CDD:238009
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1954
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D377342at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820