DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9297 and ehd1b

DIOPT Version :9

Sequence 1:	NP_001262553.1	Gene:	CG9297 / 41688	FlyBaseID:	FBgn0038181	Length:	952	Species:	Drosophila melanogaster
Sequence 2:	NP_001004578.1	Gene:	ehd1b / 447839	ZFINID:	ZDB-GENE-030131-2069	Length:	532	Species:	Danio rerio

Alignment Length:	434	Identity:	112/434 - (25%)
Similarity:	205/434 - (47%)	Gaps:	41/434 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   525 EKATDNVAEIILRDIKRIYENAVKPLETLYKYRDLSNRHFSDPEIFSKPLILFMGPWSGGKSSIL 589
            :|....:.:.:...:||:|...:.|||..|::.|..:....|.:..:||::|.:|.:|.||::.:
Zfish    10 KKKDPELFQTVSDGLKRLYRTKLFPLEDAYRFHDFHSPALEDADFDNKPMVLLVGQYSTGKTTFI 74

  Fly   590 NYLTDNEYTPNSLRTGAEPSPAYFNILMWGNETEVLDGTQLAAD--YTFAGLQKFGQGLEERLRG 652
            .:|.:.::.  .:|.|.||:...|..:|.|.:..::.|..|..|  ..|..|..||.....|...
Zfish    75 RHLMEQDFP--GMRIGPEPTTDSFIAVMHGEQEGLIPGNALVVDPKKPFRKLNAFGNAFLNRFIC 137

  Fly   653 LKMKSKILEKVNIVEIPGILEVRKQ-VSRVFPFNDACQWFIDRADIIFLVYDPAKLDVGPETEAI 716
            .:|.:.:|:.::|::.||||...|| :||.:.|....:||.:|.|.|.|::|..|||:..|...:
Zfish   138 AQMPNPVLDSISIIDTPGILSGEKQRISRGYDFAAVLEWFAERVDRIILLFDAHKLDISDEFSEV 202

  Fly   717 LDQLKGREYQTRIILNKADTVKPEELLRVQGALIWNISPLMSSAQPPLMYTTSLWTHPYQDGAPA 781
            :..||..|.:.|::|||||.:..::|:||.|||:|::..::::.:...:|..|.|..|.......
Zfish   203 IRALKNHEDKMRVVLNKADQIGTQQLMRVYGALMWSLGKIVNTPEVIRVYIGSFWAQPLLVADNR 267

  Fly   782 RLLLAQERAFLRDL----RTAIDKRIEHKIASARRFAVRVRNHAKMVDCYLNTF---NNHKTLFG 839
            :|..|:|:...||:    |.|..:::...|..||...|:....:.:.....|.|   |..|.|..
Zfish   268 KLFEAEEQDLFRDIQGLPRNAALRKLNDLIKRARLAKVQAYIISSLKKEMPNVFGKENKKKELIA 332

  Fly   840 NKKRIADDIIDHPQNYHIYEGLSTLTNISRYDLPDPEVYRDFFRLNPLYEFKKLRDTCTYFRGCP 904
            |...|...|   .:.:.|..|                   ||.:|:.:.|....:| .|.|:|..
Zfish   333 NLGEIYAKI---EKEHQISPG-------------------DFPKLSKMQEVLAGQD-FTKFQGLK 374

  Fly   905 ---ITKLDLAIAYELPELAGKYKKMSEAAL--AAIEAQQQDGTI 943
               :..::..:|.::.:|. ...:..||::  .|::....:||:
Zfish   375 PKLLESVEDMLANDIAKLM-TLVRQEEASMPSQAVQGGAFEGTM 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9297	NP_001262553.1	TSP3 repeat_long	167..205	CDD:275366
		EHD_N	539..569	CDD:293485	9/29 (31%)
		EHD	574..813	CDD:206740	74/245 (30%)
ehd1b	NP_001004578.1	EHD_N	23..55	CDD:293485	9/31 (29%)
		EHD	59..299	CDD:206740	72/241 (30%)
		EH	437..530	CDD:197477
		EH	447..512	CDD:238009
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1954
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D377342at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820