DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9297 and rme-1

DIOPT Version :9

Sequence 1:	NP_001262553.1	Gene:	CG9297 / 41688	FlyBaseID:	FBgn0038181	Length:	952	Species:	Drosophila melanogaster
Sequence 2:	NP_001367910.1	Gene:	rme-1 / 179010	WormBaseID:	WBGene00004373	Length:	791	Species:	Caenorhabditis elegans

Alignment Length:	754	Identity:	199/754 - (26%)
Similarity:	309/754 - (40%)	Gaps:	170/754 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   253 VNHEDEDLD----------GDGVKNEKDDDLDGDGTNNSQDEDLDG-----DGVPNEKD-DDLDG 301
            ||.|:..::          ....|.|::         .:|.:.::|     |.|.:|:: ..|:|
Worm     4 VNSEEHKINEAPAPPVIVINSSTKEEQE---------ATQTDRIEGQMKKIDSVFDEQNVASLEG 59

  Fly   302 DGILNEHDGDVDGDGVPNEHDHKDSGENADDDDDDDDEDDKEAVKKRSKREVDAAPVLDIEAPPS 366
            ....||..|.|.......        .||:.:|          :.:||:.|.|......:|....
Worm    60 VNSKNEISGSVSSSSFEE--------LNAETED----------LSERSEVEKDEDLGRVVEEHKE 106

  Fly   367 PAEEFPVEEEIVKEASAEEEAEVEAVKEEEPEQEAVQEPEPEP-VVEPEAEVQPEPVQQEEEKAE 430
            || :.|||.|           ..|..|:|..::|.:.|.|..| .||.|.||....|:..|.|.|
Worm   107 PA-QVPVESE-----------TPETSKKEIHQEEEISELEKVPETVEEEIEVVNTSVEITEVKKE 159

  Fly   431 SAE------AKEEEKPAPVEEAE----------------AEEESVQPEAAPK-----EPEAVQEE 468
            ..|      .||||.|.|...|:                |....:.|:|:||     ||  |:||
Worm   160 VIEEVKISGLKEEETPVPKMRAQQQVPVAADRPIRRLSIARASMMTPKASPKLAKYMEP--VREE 222

  Fly   469 AQEDEPQTDGAQDAADDDDDTKPEDELLWEGHIPENRRSRQHITELLQLDEEFNAREKATDNVAE 533
            .|:.:                |......|.|.                     ::.:|....|.|
Worm   223 GQKKK----------------KTRSMFSWLGG---------------------DSSKKKNKEVLE 250

  Fly   534 IILRDIKRIYENAVKPLETLYKYRDLSNRHFSDPEIFSKPLILFMGPWSGGKSSILNYLTDNEYT 598
            .:...:::||:..:.|||..:|:.|..:....||:..:||:||.:|.:|.||::.:.||.::::.
Worm   251 TVSEGLRKIYKQKLLPLEEFHKFHDFHSPALDDPDFDAKPMILLVGQYSTGKTTFIRYLLESDFP 315

  Fly   599 PNSLRTGAEPSPAYFNILMWGNETEVLDGTQLAAD--YTFAGLQKFGQGLEERLRGLKMKSKILE 661
              .:|.|.||:...|..:|.|:|...:.|..|..|  ..|..|..||.....|.:...:.:::||
Worm   316 --GIRIGPEPTTDRFIAVMHGDEEGSIPGNALVVDAKKQFRALSGFGNAFLNRFQCSTLPNQVLE 378

  Fly   662 KVNIVEIPGILEVRKQ-VSRVFPFNDACQWFIDRADIIFLVYDPAKLDVGPETEAILDQLKGREY 725
            .|.||:.||||...|| :.|.:.|....:||.:|.|.|.|::|..|||:..|.:..::.|.|.|.
Worm   379 SVTIVDTPGILSGEKQRIDRGYDFTGVLEWFAERVDRIILLFDAHKLDISDEFKRCIEALAGNED 443

  Fly   726 QTRIILNKADTVKPEELLRVQGALIWNISPLMSSAQPPLMYTTSLWTHPYQDGAPARLLLAQERA 790
            :.||:|||:|.|..::|:||.|||:|::..:..:.:...:|..|.|.||.......||...::..
Worm   444 KIRIVLNKSDMVDHQQLMRVYGALMWSLGKVFKTPEVSRVYLGSFWDHPLHYDLNRRLFQDEQHD 508

  Fly   791 FLRDL----RTAIDKRIEHKIASARRFAVRVRNHAKMVDCYLNTFNNHKTLFGNKKRIADDIIDH 851
            ..:||    |.|..:::...|..||...|    ||.::   ........::.|..|:..|.|
Worm   509 LFQDLQALPRNAALRKLNDLIKRARLAKV----HAYII---AELRKQMPSMIGKDKKKKDLI--- 563

  Fly   852 PQNY-HIYEGLSTLTNISRYDLPDPEVYR------DFFRLNPLYEFKKLRDTCTYFRGCPITKLD 909
             ||. .|||.|....|||..|.||....|      ||.:.|||.  .||.:.           :|
Worm   564 -QNLDKIYEQLQREHNISPGDFPDVNKMREKLQTQDFSKFNPLK--PKLLEV-----------VD 614

  Fly   910 LAIAYELPELAGKYKKMSEAALAAIEAQQQDGTIGQAEP 948
            ..:|.::..|..:..|...||.|        |:.|.|:|
Worm   615 GMLATDIARLMAQIPKEEAAAPA--------GSNGSADP 645

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9297	NP_001262553.1	TSP3 repeat_long	167..205	CDD:275366
		EHD_N	539..569	CDD:293485	9/29 (31%)
		EHD	574..813	CDD:206740	79/245 (32%)
rme-1	NP_001367910.1	EHD_N	255..287	CDD:407121	9/31 (29%)
		EHD	291..531	CDD:206740	77/241 (32%)
		DUF5600	519..625	CDD:407981	33/129 (26%)
		EH	683..776	CDD:197477
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D377342at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920