DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9297 and EHD1

DIOPT Version :9

Sequence 1:	NP_001262553.1	Gene:	CG9297 / 41688	FlyBaseID:	FBgn0038181	Length:	952	Species:	Drosophila melanogaster
Sequence 2:	NP_001269374.1	Gene:	EHD1 / 10938	HGNCID:	3242	Length:	548	Species:	Homo sapiens

Alignment Length:	408	Identity:	107/408 - (26%)
Similarity:	199/408 - (48%)	Gaps:	29/408 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   522 NAREKATDNVAEIILRDIKRIYENAVKPLETLYKYRDLSNRHFSDPEIFSKPLILFMGPWSGGKS 586
            :||.|....:.:.:...::::|...:.|||..|::.:..:....|.:..:||::|.:|.:|.||:
Human    22 DARRKKEPELFQTVAEGLRQLYAQKLLPLEEHYRFHEFHSPALEDADFDNKPMVLLVGQYSTGKT 86

  Fly   587 SILNYLTDNEYTPNSLRTGAEPSPAYFNILMWGNETEVLDGTQLAAD--YTFAGLQKFGQGLEER 649
            :.:.:|.:.::.  .:|.|.||:...|..:|.|....|:.|..|..|  ..|..|..||.....|
Human    87 TFIRHLIEQDFP--GMRIGPEPTTDSFIAVMHGPTEGVVPGNALVVDPRRPFRKLNAFGNAFLNR 149

  Fly   650 LRGLKMKSKILEKVNIVEIPGILEVRKQ-VSRVFPFNDACQWFIDRADIIFLVYDPAKLDVGPET 713
            ....::.:.:|:.::|::.||||...|| :||.:.|....:||.:|.|.|.|::|..|||:..|.
Human   150 FMCAQLPNPVLDSISIIDTPGILSGEKQRISRGYDFAAVLEWFAERVDRIILLFDAHKLDISDEF 214

  Fly   714 EAILDQLKGREYQTRIILNKADTVKPEELLRVQGALIWNISPLMSSAQPPLMYTTSLWTHPYQDG 778
            ..::..||..|.:.|::|||||.::.::|:||.|||:|::..::::.:...:|..|.|:||....
Human   215 SEVIKALKNHEDKIRVVLNKADQIETQQLMRVYGALMWSLGKIINTPEVVRVYIGSFWSHPLLIP 279

  Fly   779 APARLLLAQERAFLRDL----RTAIDKRIEHKIASARRFAVRVRNHAKMVDCYLNTFNNHKTLFG 839
            ...:|..|:|:...:|:    |.|..:::...|..||...|    ||.::........|   :||
Human   280 DNRKLFEAEEQDLFKDIQSLPRNAALRKLNDLIKRARLAKV----HAYIISSLKKEMPN---VFG 337

  Fly   840 ---NKKRIADDIIDHPQNYHIYEGLSTLTNISRYDLPDPEVYRDFFRLNPLYEFK----KLRDTC 897
               .||.:.:::.:      ||:.:.....||..|.|.....::..:.....:|:    ||.||.
Human   338 KESKKKELVNNLGE------IYQKIEREHQISPGDFPSLRKMQELLQTQDFSKFQALKPKLLDTV 396

  Fly   898 TYFRGCPITKLDLAIAYE 915
            .......|.:|.:.:..|
Human   397 DDMLANDIARLMVMVRQE 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9297	NP_001262553.1	TSP3 repeat_long	167..205	CDD:275366
		EHD_N	539..569	CDD:293485	6/29 (21%)
		EHD	574..813	CDD:206740	74/245 (30%)
EHD1	NP_001269374.1	EHD_N	39..70	CDD:318972	6/30 (20%)
		EHD	74..314	CDD:206740	72/241 (30%)
		EH	452..545	CDD:197477
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1954
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D377342at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820