DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cht5 and chit1

DIOPT Version :9

Sequence 1:	NP_650314.1	Gene:	Cht5 / 41687	FlyBaseID:	FBgn0038180	Length:	595	Species:	Drosophila melanogaster
Sequence 2:	NP_001005792.1	Gene:	chit1 / 448265	XenbaseID:	XB-GENE-5801457	Length:	492	Species:	Xenopus tropicalis

Alignment Length:	564	Identity:	179/564 - (31%)
Similarity:	269/564 - (47%)	Gaps:	113/564 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 ASRIVCYFSNWAVYRTGIGRYGLEDVPADLCTHIIYSFIGVNDK-----SW--DVLVIDPELDVD 83
            |.::||||:||:.||....:|...::...||||:||:|..:|..     .|  |||
Frog    21 AYKLVCYFTNWSQYRPEPAKYMPGNIDPKLCTHLIYAFATMNSNKIAPYEWNDDVL--------- 76

  Fly    84 QGGFSKFTQLKKSNPNVKLEIAVGGWAEGGSKYSQMVAVRDRRQSFIRSVVRFMKQYNFDGFDLD 148
               :.::..||:.|||:...:|:|||..|..|:::||:....|:.||.||:.:::.|.|:|.|||
Frog    77 ---YKQYNALKQQNPNLVTLLAIGGWNFGTQKFTEMVSSAGNRKIFIDSVIEYLRLYGFNGIDLD 138

  Fly   149 WEYPGATDRGGNYGDKDKFLYFVEELRRAFDREGRGWE-----ITMAVPVAKFRLNEGYHVPELC 208
            :||||:  ||....||.:|....:|:.:||:.|.....     :|.||...|..::.||.:.|:.
Frog   139 FEYPGS--RGSPPEDKHRFTILTQEMLKAFEDEAAATNQSRLLMTAAVSAGKGTIDAGYEIAEIG 201

  Fly   209 EALDAIHAMTYDLRGNWAGFADVHSPLYKRKHDQYAYEKLNVNDGLALWEEMGCPANKLVVGVPF 273
            :.||.|..||||..|.|...:..:|||.|...|...::..|:...:..|::.|.||.||::|.|.
Frog   202 KTLDFISVMTYDFHGGWDPVSGHNSPLCKGSKDTGDFQYFNIRYAMNYWKDNGVPAQKLLIGFPT 266

  Fly   274 YGRTFTLSNSNKNYNMGTYINKEAGGGAPGPYTNASGFLAYYEICTEVMDKSKGWTVEWDDAGMV 338
            |||||...|.: |.::|..:   :|.|:.|.||..:||.|||||||.:    .|.|:.|.....|
Frog   267 YGRTFRNPNPS-NCDVGIPV---SGAGSAGQYTREAGFWAYYEICTWL----SGTTINWIADQKV 323

  Fly   339 PYTYKDTQWVGYENEASIQIKMDFIKQRGYAGAMTWAIDMDDFHG-MCGRKNGLTQILYDNMKNY 402
            ||..|..:|||::|:.|.:.|:.|:|:.|:||||.||||:|||.| .|   |.....|..::|:.
Frog   324 PYACKGNEWVGFDNQDSYECKVKFLKESGFAGAMVWAIDLDDFSGTFC---NQGKYPLISHLKSL 385

  Fly   403 RVPEPTRQTTPRPEWAKPPATPPNPDEGAVVAPTTSTTKRPKPKPKPTSSPLSPTSAPGPVPTVG 467
            .....|:             .|.||.:   :.||       :| |.||:|..:.|
Frog   386 LEGSVTK-------------CPGNPCD---IVPT-------EP-PSPTTSGETTT---------- 416

  Fly   468 SSTPKPTTKKPKKPKKTTTTTTTTPAPEKSTEEPEEVVYPVDPVEPTDPEQPMGPQFDPNEIDCT 532
             |..|||      |.:|||:|||:                             |.:.|||  .|.
Frog   417 -SQAKPT------PGETTTSTTTS-----------------------------GDEVDPN--FCA 443

  Fly   533 NRD---FVPHPNCRKYFRCVHGKPVEFECKEGTAFHTVLNVCDW 573
            .:.   :....|..:::.|..|.....:|.:|..|......|:|
Frog   444 GKSDGLYENRINFNRFYICAGGSTYPMKCADGLVFDEACKCCNW 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cht5	NP_650314.1	Glyco_18	28..379	CDD:214753	134/362 (37%)
		GH18_chitolectin_chitotriosidase	29..397	CDD:119351	141/380 (37%)
		Trypan_PARP	367..469	CDD:114603	29/102 (28%)
		CBM_14	531..578	CDD:279884	9/46 (20%)
chit1	NP_001005792.1	GH18_chitolectin_chitotriosidase	24..386	CDD:119351	142/386 (37%)
chit1	NP_001005792.1	CBM_14	442..491	CDD:366726	9/46 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1289629at2759
OrthoFinder	1	1.000	-	-		FOG0000107
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X91
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.920