DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cht5 and Cht10

DIOPT Version :9

Sequence 1:	NP_650314.1	Gene:	Cht5 / 41687	FlyBaseID:	FBgn0038180	Length:	595	Species:	Drosophila melanogaster
Sequence 2:	NP_001036422.1	Gene:	Cht10 / 3355116	FlyBaseID:	FBgn0250907	Length:	2286	Species:	Drosophila melanogaster

Alignment Length:	660	Identity:	193/660 - (29%)
Similarity:	286/660 - (43%)	Gaps:	148/660 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 CSWPAATVASDQAS------------------------------------------RIVCYFSNW 36
            |.||||...:.:.|                                          :::|||:||
  Fly   910 CDWPAAAKCNPKGSESSEEAELNAMPKPPTPQTPSSHLRPTYPTEKPVPKPRDSHYKVICYFTNW 974

  Fly    37 AVYRTGIGRYGLEDVPADLCTHIIYSFIGVNDKSWDVL-VIDPELDVDQGGFSKFTQLKKSNPNV 100
            |.||.||||:..:|:..:||||:||.| .|.|.|..|| ..|...||:...:::.|.||  :..:
  Fly   975 AWYRKGIGRFTPDDINTELCTHVIYGF-AVLDYSELVLRTHDSWADVENNFYTRVTSLK--SKGI 1036

  Fly   101 KLEIAVGGWAEG-GSKYSQMVAVRDRRQSFIRSVVRFMKQYNFDGFDLDWEYPGATDRGGNYG-- 162
            |:.:|:|||.:. |.|||::|.....|..|:|..:.|:::|.|:|.|||||||.......|.|
  Fly  1037 KVSLALGGWNDSQGDKYSRLVRSPMARSRFVRHALEFIEKYGFEGLDLDWEYPVCWQTECNKGST 1101

  Fly   163 -DKDKFLYFVEELRRAFDREGRGWEITMAVPVAKFRLNEGYHVPELCEALDAIHAMTYDLRGNWA 226
             :||.|..:|:||..||  ..||..::.||..::..::.||.:|:|....|.|..||||..|:|.
  Fly  1102 EEKDGFTAWVQELSEAF--RPRGLMLSTAVSPSRKIIDAGYDIPQLSRYFDWIAVMTYDFHGHWD 1164

  Fly   227 GFADVHSPLYKRKHDQYAYEKLNVNDGLALWEEMGCPANKLVVGVPFYGRTFTLSNSNKNYNMGT 291
            ......:|||....|.:.|  .|||..:..|.|.|.|:.|||:|:|.||::|||.|:|     .:
  Fly  1165 KKTGHVAPLYHHPDDDFEY--FNVNYSINYWMEKGAPSQKLVMGIPLYGQSFTLENTN-----SS 1222

  Fly   292 YINKEA-GGGAPGPYTNASGFLAYYEICTEVMDKSKGWTVEWDDAG-MVPYTYKDTQWVGYENEA 354
            .:|.:| ..|..|.:|.|:|||||||||..|  ..:||.|..|:.| |.||.||.||||.|::..
  Fly  1223 GLNAKAPAPGEAGEFTRAAGFLAYYEICERV--NRQGWQVVHDEFGRMGPYAYKGTQWVSYDSPD 1285

  Fly   355 SIQIKMDFIKQRGYAGAMTWAIDMDDFHGMCGRKNGLTQILYDNMKNYRVPEPTRQTTPRPEWAK 419
            .::.|...::.....|.|.||:|:|||...||  ||:..:|.: :.|.....|:....|.|
  Fly  1286 MVRKKSLLVRSLKLGGGMVWALDLDDFKNRCG--NGVHPLLTE-IHNVLKDPPSLMEIPGP---- 1343

  Fly   420 PPATPPNPDEGAVVAPTTSTTKRPKPKPKPTSSPLSPTSAPGPVPTVGSSTPKPTTKKPKKPKKT 484
                             ..||               ||..||....:..|..:....:|.:....
  Fly  1344 -----------------IETT---------------PTEYPGMEEEIHESNGEGPEVQPIEAVMQ 1376

  Fly   485 TTTTTTTPAPEKSTEEPEEVVYPVDPVEPTDPE--------------------QPMGPQFDPNEI 529
            |.        |...||.|.::.|...:|..:.|                    :..|.:|.|.:|
  Fly  1377 TC--------ENEGEEHEGILDPNHVLEEENIEATEMATEFKIICYFTNWAWYRQGGGKFLPEDI 1433

  Fly   530 D---CT------------NRDFVPHPNCRKYFRCVHGKPVEFECKEGTAFHTVLNVCDWIENSDR 579
            |   ||            |....||.:........:.:.|.:. |:|.  ...:.:..|.:::..
  Fly  1434 DSDLCTHIIYGFAVLSRDNLTIQPHDSWADLDNKFYERIVAYR-KKGA--KVTVAIGGWNDSAGD 1495

  Fly   580 YYCSRMKNKE 589
            .|...::|.|
  Fly  1496 KYSRLVRNPE 1505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cht5	NP_650314.1	Glyco_18	28..379	CDD:214753	142/357 (40%)
		GH18_chitolectin_chitotriosidase	29..397	CDD:119351	150/374 (40%)
		Trypan_PARP	367..469	CDD:114603	23/101 (23%)
		CBM_14	531..578	CDD:279884	9/58 (16%)
Cht10	NP_001036422.1	Glyco_18	220..565	CDD:214753
		GH18_chitolectin_chitotriosidase	221..586	CDD:119351
		ChtBD2	697..737	CDD:214696
		CBM_14	801..848	CDD:279884
		CBM_14	875..918	CDD:279884	5/7 (71%)
		Glyco_18	966..1310	CDD:214753	142/357 (40%)
		GH18_chitolectin_chitotriosidase	967..1331	CDD:119351	151/380 (40%)
		Glyco_18	1410..1753	CDD:214753	17/99 (17%)
		GH18_chitolectin_chitotriosidase	1411..1774	CDD:119351	17/98 (17%)
		ChtBD2	1834..1871	CDD:214696
		Glyco_18	1909..2253	CDD:214753
		GH18_chitolectin_chitotriosidase	1910..2274	CDD:119351
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	188	1.000	Domainoid score	I962
eggNOG	1	0.900	-	-		E1_COG3325
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264489at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm1002
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11177
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.920