DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cht5 and Chit1

DIOPT Version :9

Sequence 1:	NP_650314.1	Gene:	Cht5 / 41687	FlyBaseID:	FBgn0038180	Length:	595	Species:	Drosophila melanogaster
Sequence 2:	NP_001073157.1	Gene:	Chit1 / 289032	RGDID:	1305646	Length:	464	Species:	Rattus norvegicus

Alignment Length:	591	Identity:	176/591 - (29%)
Similarity:	267/591 - (45%)	Gaps:	156/591 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LLLLGV----LCSWPAATVASDQASRIVCYFSNWAVYRTGIGRYGLEDVPADLCTHIIYSFIGVN 67
            |.|.||    :..|       ..|:::.|||:|||.||:|..|:...||..:||||:||:|.|:|
  Rat     5 LALAGVTTLLMIQW-------GSAAKLFCYFTNWAQYRSGAARFLPRDVDPNLCTHVIYAFAGLN 62

  Fly    68 DKSWDVLVIDPELDVDQGGFSKFTQLKKSNPNVKLEIAVGGWAEGGSKYSQMVAVRDRRQSFIRS 132
            :.  .|..::|.   |:..:.:...|||.||.:|..:|||||:.|..|::.|||....||:|:.|
  Rat    63 NH--QVSTVEPN---DELFYQELNSLKKRNPKLKTLLAVGGWSFGTQKFTDMVATASTRQTFVNS 122

  Fly   133 VVRFMKQYNFDGFDLDWEYPGATDRGGNYGDKDKFLYFVEELRRAFDREGRG-----WEITMAVP 192
            .:.|::.:.|||.||||||||:  ||....||::|...:::|.:||..|.|.     ..:|.|||
  Rat   123 ALSFLRTHGFDGLDLDWEYPGS--RGSPAVDKERFTALIQDLAKAFQEEARASGKSRLLLTAAVP 185

  Fly   193 VAKFRLNEGYHVPELCEALDAIHAMTYDLRGNWAGFADVHSPLYKRKHDQYAYEKLNVNDGLALW 257
            ..:..::.||.|.::.::||.|:.|.||...:|......:||||||:.:.....:.||:..:.||
  Rat   186 TGRGHVDAGYEVDKIVQSLDFINLMAYDFHSSWDKTTGHNSPLYKRQGETGKDAEKNVDAAVTLW 250

  Fly   258 EEMGCPANKLVVGVPFYGRTFTLSNSNKNYNMGTYINKEAGGGAPGPYTNASGFLAYYEICT--- 319
            .:.|.||:||::|:|.|||:|||::|:.: .:|.   ...|.|||||||...|.|.|:|:|:
  Rat   251 LQKGTPASKLMLGMPAYGRSFTLASSSDS-GVGA---PATGPGAPGPYTKEKGILVYFEVCSWKG 311

  Fly   320 --EVMDKSKGWTVEWDDAGMVPYTYKDTQWVGYENEASIQIKMDFIKQRGYAGAMTWAIDMDDFH 382
              .:.|:.            |||..:..||||:::..|.:.|..::||:|..|||.|.:|.|||.
  Rat   312 KQRIEDQK------------VPYVSQGNQWVGFDDRESFRAKAAYVKQKGLGGAMVWILDGDDFK 364

  Fly   383 G-MCGRKNGLTQILYDNMKNYRVPEPTRQTTPRPEWAKPPATPPNPDEGAVVAPTTSTTKRPKPK 446
            | .|                                          :||..            |.
  Rat   365 GSFC------------------------------------------NEGQY------------PL 375

  Fly   447 PKPTSSPLSPTSAPGPVPTVGSSTPKPTTKKPKKPKKTTTTTTTTPAPEKSTEEPEEVVYPVDPV 511
            .:.....||.:|.|                 |:.|::               |.|       .|.
  Rat   376 IRTLHQELSLSSGP-----------------PRSPEQ---------------EVP-------GPH 401

  Fly   512 EPTDPEQPMGPQFDPNEIDCTNRDF--------VPHPNCR-KYFRCVHGKPVEFECKEGTAFHTV 567
            :|::|||...|..|         ||        .|:|..: .::.|..|:..:..|..|..|...
  Rat   402 QPSEPEQGPSPGLD---------DFCQGKADGLYPNPTEKSSFYSCGGGRLFQHSCPPGLVFIDS 457

  Fly   568 LNVCDW 573
            ...|.|
  Rat   458 CKCCTW 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cht5	NP_650314.1	Glyco_18	28..379	CDD:214753	136/360 (38%)
		GH18_chitolectin_chitotriosidase	29..397	CDD:119351	141/378 (37%)
		Trypan_PARP	367..469	CDD:114603	18/102 (18%)
		CBM_14	531..578	CDD:279884	11/52 (21%)
Chit1	NP_001073157.1	GH18_chitolectin_chitotriosidase	24..383	CDD:119351	144/435 (33%)
Chit1	NP_001073157.1	ChtBD2	416..463	CDD:214696	10/46 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1289629at2759
OrthoFinder	1	1.000	-	-		FOG0000107
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X91
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.920