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Protein Alignment Cht5 and CHIA

DIOPT Version :9

Sequence 1:	NP_650314.1	Gene:	Cht5 / 41687	FlyBaseID:	FBgn0038180	Length:	595	Species:	Drosophila melanogaster
Sequence 2:	NP_970615.2	Gene:	CHIA / 27159	HGNCID:	17432	Length:	476	Species:	Homo sapiens

Alignment Length:	561	Identity:	178/561 - (31%)
Similarity:	254/561 - (45%)	Gaps:	119/561 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 ASRIVCYFSNWAVYRTGIGRYGLEDVPADLCTHIIYSFIG-----VNDKSWDVLVIDPELDVDQG 85
            |.::.|||:|||.||.|:||:..:::...||||:||:|.|     :....|:.:.:
Human    21 AYQLTCYFTNWAQYRPGLGRFMPDNIDPCLCTHLIYAFAGRQNNEITTIEWNDVTL--------- 76

  Fly    86 GFSKFTQLKKSNPNVKLEIAVGGWAEGGSKYSQMVAVRDRRQSFIRSVVRFMKQYNFDGFDLDWE 150
             :..|..||..|..:|..:|:|||..|.:.::.||:..:.||:||.||::|::||.|||.|.|||
Human    77 -YQAFNGLKNKNSQLKTLLAIGGWNFGTAPFTAMVSTPENRQTFITSVIKFLRQYEFDGLDFDWE 140

  Fly   151 YPGATDRGGNYGDKDKFLYFVEELRRAFDREGRGWE-----ITMAVPVAKFRLNEGYHVPELCEA 210
            |||:  ||....||..|...|:|:|.||::|.:...     :|.||......:..||.:|:|.:.
Human   141 YPGS--RGSPPQDKHLFTVLVQEMREAFEQEAKQINKPRLMVTAAVAAGISNIQSGYEIPQLSQY 203

  Fly   211 LDAIHAMTYDLRGNWAGFADVHSPLYKRKHDQYAYEKLNVNDGLALWEEMGCPANKLVVGVPFYG 275
            ||.||.|||||.|:|.|:...:|||||...|..:...|||:..:..|::.|.||.||:||.|.||
Human   204 LDYIHVMTYDLHGSWEGYTGENSPLYKYPTDTGSNAYLNVDYVMNYWKDNGAPAEKLIVGFPTYG 268

  Fly   276 RTFTLSNSNKNYNMGTYINKEAGGGAPGPYTNASGFLAYYEICTEVMDKSKGWTVEWDDAGMVPY 340
            ..|.|||.: |..:|.   ..:|.|..|||...||..|||||||.:   ..|.|..||....|||
Human   269 HNFILSNPS-NTGIGA---PTSGAGPAGPYAKESGIWAYYEICTFL---KNGATQGWDAPQEVPY 326

  Fly   341 TYKDTQWVGYENEASIQIKMDFIKQRGYAGAMTWAIDMDDFHGMCGRKNGLTQILYDNMKNYRVP 405
            .|:...||||:|..|..||..::|...:.|||.||||:|||.|           .:.|...:
Human   327 AYQGNVWVGYDNIKSFDIKAQWLKHNKFGGAMVWAIDLDDFTG-----------TFCNQGKF--- 377

  Fly   406 EPTRQTTPRPEWAKPPATPPNPDEGAVVAPTTSTTKRPKPKPKPTSSPLSPTSAPGPVPTVGSST 470
             |...|..:                |:...:.|.|...:|....|::|....:..|...:.|||.
Human   378 -PLISTLKK----------------ALGLQSASCTAPAQPIEPITAAPSGSGNGSGSSSSGGSSG 425

  Fly   471 PKPTTKKPKKPKKTTTTTTTTPAPEKSTEEPEEVVYPVDPVEPTDPEQPMGPQFDPNEIDCTNRD 535
                                                              |..|      |..|.
Human   426 --------------------------------------------------GSGF------CAVRA 434

  Fly   536 FVPHP---NCRKYFRCVHGKPVEFECKEGTAFHTVLNVCDW 573
            ...:|   |...::.||:|...:..|:.|..|.|..:.|:|
Human   435 NGLYPVANNRNAFWHCVNGVTYQQNCQAGLVFDTSCDCCNW 475

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.