DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cht5 and cht-1

DIOPT Version :9

Sequence 1:	NP_650314.1	Gene:	Cht5 / 41687	FlyBaseID:	FBgn0038180	Length:	595	Species:	Drosophila melanogaster
Sequence 2:	NP_508588.1	Gene:	cht-1 / 180628	WormBaseID:	WBGene00000503	Length:	617	Species:	Caenorhabditis elegans

Alignment Length:	650	Identity:	190/650 - (29%)
Similarity:	274/650 - (42%)	Gaps:	140/650 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LLGVLCSWPAATVASDQA----------SRIV------------CYFSNWAVYRTGIGRYGLEDV 51
            :|.:..:|..||:.:..|          ||.|            |||:|||.||.|..::..||.
Worm    13 ILPIAYTWTGATIRNHPADVVAARNKITSRSVARSEPTNSYIRPCYFTNWAQYRQGRAKFVPEDY 77

  Fly    52 PADLCTHIIYSFIGVNDKSWDVLVIDP-ELDVD---QGGFSKFTQLKKSNPNVKLEIAVGGWAEG 112
            ...|||||:::| |..:..:.|...|| :|..|   :|.:.:..:||.::..:|..::.|||:.|
Worm    78 TPGLCTHILFAF-GWMNADYTVRAYDPADLPNDWAGEGMYRRVNKLKVTDTQLKTLLSFGGWSFG 141

  Fly   113 GSKYSQMVAVRDRRQSFIRSVVRFMKQYNFDGFDLDWEYP-GATDRGGNYGDKDKFLYFVEELRR 176
            .:.:..|.|....|:.||.|.:.|::.:.|||.|:||||| ||||. .||      :..|:||:.
Worm   142 TALFQGMAASSASRKVFIDSAITFVRTWGFDGIDIDWEYPSGATDM-ANY------VALVKELKA 199

  Fly   177 AFDRE--GRGWE---ITMAVPVAKFRLNEGYHVPELCEALDAIHAMTYDLRGNWAGFADVHSPLY 236
            |.:.|  ..|.:   :|.||......::.||.:|.|....|.|..|:||..|.||.....:||||
Worm   200 ACESEAGSTGKDRLLVTAAVAAGPATIDAGYDIPNLAPNFDFILLMSYDFFGAWASLVGFNSPLY 264

  Fly   237 KRKHDQYAYEKLNVNDGLALWEEMGCPANKLVVGVPFYGRTFTLSNSNKNYNMGTYINKEAGGGA 301
            ........:...||:.....|.:.|.|..|::||:|.|||.:||:|::. .|.||       .|:
Worm   265 ATTELPAEWNGWNVDSSARYWNQKGMPKEKIIVGMPTYGRGWTLNNASA-INPGT-------SGS 321

  Fly   302 PG---PYTNASGFLAYYEICTEVMDKSKGWTVEWDDAGMVPYTYKDTQWVGYENEASIQIKMDFI 363
            |.   .|...:|..||:|.| |::  :.|.|..||....|||..:..||..|::|.|...||.::
Worm   322 PAKITQYVQEAGVGAYFEFC-EML--ANGATRYWDSQSQVPYLVQGNQWWSYDDEESFANKMAYV 383

  Fly   364 KQRGYAGAMTWAIDMDDFHGMCGRKNG----LTQILYDNMKNYRVPEPTRQTTPRPEWAKPPATP 424
            |:.||.||..|.:|.|||:..|...||    |..::...:....:|:....||.....|....|.
Worm   384 KREGYGGAFVWTLDFDDFNAGCSNSNGQLYPLISVIAKELGGVIIPKKGGVTTAPTTVATTVTTG 448

  Fly   425 PNPDEGAVVAPTTSTTKRPKPKPKPTSSPLSPTS--APGPVPTVG-------------------- 467
            ..|...||...|.:||...:.....|:|..:..|  :.|..|...
Worm   449 RPPMTSAVTTTTAATTTTTRAATTTTASNTNVCSGKSDGFYPNSNNCGLFVLCLSSKSYSMSCPS 513

  Fly   468 ---------------------SSTPKPTTKKPKKPKKTTTT---TTTTPAPEKSTEEPEEVVYPV 508
                                 ::|..|||.....|..||||   ||||||
Worm   514 GLQYSASLKYCTTSTASGCSVTTTRAPTTTTKSAPTVTTTTRAPTTTTPA--------------- 563

  Fly   509 DPVEPTDPEQPMGPQFDPNEIDCTNRDFVPHP-NCRKYFRCVHGKPVEFECKEGTAFHTVLNVCD 572
                                ..||...|...| :|.|:.|||:|....|||..|.:||....:||
Worm   564 --------------------FKCTKDGFFGVPSDCLKFIRCVNGISYNFECPNGLSFHADTMMCD 608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cht5	NP_650314.1	Glyco_18	28..379	CDD:214753	128/375 (34%)
		GH18_chitolectin_chitotriosidase	29..397	CDD:119351	134/396 (34%)
		Trypan_PARP	367..469	CDD:114603	29/148 (20%)
		CBM_14	531..578	CDD:279884	17/42 (40%)
cht-1	NP_508588.1	GH18_chitolectin_chitotriosidase	55..423	CDD:119351	133/386 (34%)
		Glyco_18	57..399	CDD:214753	126/360 (35%)
		CBM_14	481..532	CDD:279884	3/50 (6%)
		CBM_14	567..615	CDD:279884	16/41 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3325
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1289629at2759
OrthoFinder	1	1.000	-	-		FOG0000107
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11177
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X91
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.920