back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cht5 and CHIT1

DIOPT Version :9

Sequence 1:	NP_650314.1	Gene:	Cht5 / 41687	FlyBaseID:	FBgn0038180	Length:	595	Species:	Drosophila melanogaster
Sequence 2:	NP_003456.1	Gene:	CHIT1 / 1118	HGNCID:	1936	Length:	466	Species:	Homo sapiens

Alignment Length:	563	Identity:	176/563 - (31%)
Similarity:	269/563 - (47%)	Gaps:	133/563 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 ASRIVCYFSNWAVYRTGIGRYGLEDVPADLCTHIIYSFIGVND-----KSWDVLVIDPELDVDQG 85
            |:::||||:|||.||.|..|:..:|:...||||:||:|.|:.:     ..|:          |:.
Human    21 AAKLVCYFTNWAQYRQGEARFLPKDLDPSLCTHLIYAFAGMTNHQLSTTEWN----------DET 75

  Fly    86 GFSKFTQLKKSNPNVKLEIAVGGWAEGGSKYSQMVAVRDRRQSFIRSVVRFMKQYNFDGFDLDWE 150
            .:.:|..|||.||.:|..:|:|||..|..|::.|||..:.||:|:.|.:||:::|:|||.|||||
Human    76 LYQEFNGLKKMNPKLKTLLAIGGWNFGTQKFTDMVATANNRQTFVNSAIRFLRKYSFDGLDLDWE 140

  Fly   151 YPGATDRGGNYGDKDKFLYFVEELRRAFDREGR--GWE---ITMAVPVAKFRLNEGYHVPELCEA 210
            |||:  :|....||::|...|::|..||.:|.:  |.|   ::.|||..:..::.||.|.::.:.
Human   141 YPGS--QGSPAVDKERFTTLVQDLANAFQQEAQTSGKERLLLSAAVPAGQTYVDAGYEVDKIAQN 203

  Fly   211 LDAIHAMTYDLRGNWAGFADVHSPLYKRKHDQYAYEKLNVNDGLALWEEMGCPANKLVVGVPFYG 275
            ||.::.|.||..|:|......:||||||:.:..|...|||:..:..|.:.|.||:||::|:|.||
Human   204 LDFVNLMAYDFHGSWEKVTGHNSPLYKRQEESGAAASLNVDAAVQQWLQKGTPASKLILGMPTYG 268

  Fly   276 RTFTLSNSNKNYNMGTYINKEA-GGGAPGPYTNASGFLAYYEICTEVMDKSKGWTVEWDDAGMVP 339
            |:|||::|:     .|.:...| |.|.|||:|...|.|||||:|:     .||.|.:......||
Human   269 RSFTLASSS-----DTRVGAPATGSGTPGPFTKEGGMLAYYEVCS-----WKGATKQRIQDQKVP 323

  Fly   340 YTYKDTQWVGYENEASIQIKMDFIKQRGYAGAMTWAIDMDDFHGM-CGRKNGLTQILYDNMKNYR 403
            |.::|.||||:::..|.:.|:.::||:|..|||.||:|:|||.|. |            |...|.
Human   324 YIFRDNQWVGFDDVESFKTKVSYLKQKGLGGAMVWALDLDDFAGFSC------------NQGRYP 376

  Fly   404 VPEPTRQTTPRPEWAKPPATPPNPDEGAVVAPTTSTTKRPKPKPKPTSSPLSPTSAPGPVPTVGS 468
            :.:..||                                          .||       :|.:.|
Human   377 LIQTLRQ------------------------------------------ELS-------LPYLPS 392

  Fly   469 STPKPTTKKPKKPKKTTTTTTTTPAPEKSTEEPEEVVYPVDPVEPTDPEQPMGPQFDPNEIDCTN 533
            .||:....||.                                :|::||....|..|   ..|..
Human   393 GTPELEVPKPG--------------------------------QPSEPEHGPSPGQD---TFCQG 422

  Fly   534 RDFVPHPNCRK---YFRCVHGKPVEFECKEGTAFHTVLNVCDW 573
            :....:||.|:   ::.|..|:..:..|..|..|......|.|
Human   423 KADGLYPNPRERSSFYSCAAGRLFQQSCPTGLVFSNSCKCCTW 465

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.