DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Adgf-C and ADA2

DIOPT Version :9

Sequence 1:	NP_650308.3	Gene:	Adgf-C / 41680	FlyBaseID:	FBgn0038173	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_001269154.1	Gene:	ADA2 / 51816	HGNCID:	1839	Length:	511	Species:	Homo sapiens

Alignment Length:	516	Identity:	198/516 - (38%)
Similarity:	290/516 - (56%)	Gaps:	33/516 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 RRLLMFVVLLTAQLQIQAQTALSYEQARQAVLTAEEELMTGGHTHLNTEEEKVDDIFMEYKLGEL 66
            |..|.|::|..|....  .:|||.::.|..:|..|:.:..||...|||:||..::..|..|:.|:
Human     9 RPALCFLLLAVAMSFF--GSALSIDETRAHLLLKEKMMRLGGRLVLNTKEELANERLMTLKIAEM 71

  Fly    67 AQGFRNAEQNAAALHFFKAKPLIDRSAIFRFLQKMPKGSVLHVHNTASVSSKWVVDDLSYMPGLL 131
            .:..|.. ....::|||:||.||:||.:|..|:.||||:.||:|:...|:..|:|.:::|.|...
Human    72 KEAMRTL-IFPPSMHFFQAKHLIERSQVFNILRMMPKGAALHLHDIGIVTMDWLVRNVTYRPHCH 135

  Fly   132 RCTTATGQSILSFR---RTPK-EHKCQSQYVLVSDERRNSLDRQVYDRNFERLINLYTPVPELEY 192
            .|.|..|  |:.||   .||: ..|| |:::|:.|.|:...:...:|.:..|...|.|..||:.|
Human   136 ICFTPRG--IMQFRFAHPTPRPSEKC-SKWILLEDYRKRVQNVTEFDDSLLRNFTLVTQHPEVIY 197

  Fly   193 PTITRVWDRFQGMFDGLSDALIYLPAFRAYHWQMLEELYNDNVMYTEIRTSFKTLYDASGRTFPR 257
            .....||.:|:.:|..:|..:.|.|.||.|.::.::|.|.|||:|.|||.....:|:.||.....
Human   198 TNQNVVWSKFETIFFTISGLIHYAPVFRDYVFRSMQEFYEDNVLYMEIRARLLPVYELSGEHHDE 262

  Fly   258 ERTIHELYALNQKFMKLHPDFLGFKVIMAVYRGYELDHLKDIVEVFKKLHQAL------PHFLVG 316
            |.::.....:.|||::.||:|:|.|:|.:.:|.      ||:..:.:.:..|:      |..:.|
Human   263 EWSVKTYQEVAQKFVETHPEFIGIKIIYSDHRS------KDVAVIAESIRMAMGLRIKFPTVVAG 321

  Fly   317 FDLVGQEDKGKPLY----SLLPVLRD---LPPTARLFLHGGETNWFGASTDINLLDALLMNTTRI 374
            |||||.||.|..|:    :|:...:|   ||    .|.|.|||:|.|.|.|.|:||||::|||||
Human   322 FDLVGHEDTGHSLHDYKEALMIPAKDGVKLP----YFFHAGETDWQGTSIDRNILDALMLNTTRI 382

  Fly   375 GHGYALAKHPILLNAVKSRRIAVELSPISNQVLHLVWDLRNHPGSQFFALDVPVVICNDDPGFWN 439
            |||:||:|||.:......:.|.:|:.|||||||.||.||||||.:...|...|:||.:|||..:.
Human   383 GHGFALSKHPAVRTYSWKKDIPIEVCPISNQVLKLVSDLRNHPVATLMATGHPMVISSDDPAMFG 447

  Fly   440 AKGLSYDFYYAIMSLAPNNAGLRLLKTLVWNSVRYSTLTEEEQTRAFKILELSWSRFIDDV 500
            |||||||||...|.:....|.||.||.|..||::||||.|.|:....:|.:..|.:||.||
Human   448 AKGLSYDFYEVFMGIGGMKADLRTLKQLAMNSIKYSTLLESEKNTFMEIWKKRWDKFIADV 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Adgf-C	NP_650308.3	A_deaminase_N	5..98	CDD:285627	31/92 (34%)
		adm_rel	25..501	CDD:273620	190/493 (39%)
		ADGF	78..493	CDD:238646	171/431 (40%)
ADA2	NP_001269154.1	A_deaminase_N	12..102	CDD:285627	31/92 (34%)
		adm_rel	30..509	CDD:273620	190/493 (39%)
		Dimerization	30..100		23/70 (33%)
		ADGF	82..501	CDD:238646	171/431 (40%)
		PRB domain	127..185		17/60 (28%)
		Substrate binding	204..211		2/6 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159071
Domainoid	1	1.000	52	1.000	Domainoid score	I11472
eggNOG	1	0.900	-	-		E1_COG1816
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H81852
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56251
OrthoDB	1	1.010	-	-		D197912at33208
OrthoFinder	1	1.000	-	-		FOG0003006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104612
Panther	1	1.100	-	-	O	PTHR11409
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.720