DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Adgf-C and Adgf-B

DIOPT Version :9

Sequence 1:	NP_650308.3	Gene:	Adgf-C / 41680	FlyBaseID:	FBgn0038173	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_649006.2	Gene:	Adgf-B / 39975	FlyBaseID:	FBgn0036751	Length:	520	Species:	Drosophila melanogaster

Alignment Length:	501	Identity:	178/501 - (35%)
Similarity:	270/501 - (53%)	Gaps:	17/501 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 VLLTAQLQIQAQTALSYEQARQAVLTAEEELMTGGHTHLNTEEEKVDDIFMEYKLGELAQGFRNA 73
            |.::..|:..:.||  ::..|||:.......:.|....||..|...:.:.|..|..|:::|..:.
  Fly    26 VSVSRSLRKLSPTA--FKTLRQAIAKVGHLNIMGQKIRLNDRELAANKVIMAVKKEEISKGILDP 88

  Fly    74 EQNAAALHFFKAKPLIDRSAIFRFLQKMPKGSVLHVHNTASVSSKWVVDDLSYMPGLLRCTTATG 138
            .|.....|.||....:.:|.||..::.||||..||.|:||..|:.::: .|:|...|..||...|
  Fly    89 SQFTPGQHIFKTLAEVQKSPIFNLIKGMPKGGALHAHDTALCSTDYLI-SLTYRKNLWICTAEEG 152

  Fly   139 QSILSFR---RTPKEHKCQSQYVLVSDERRNSLDRQVYDRNFERLINLYTPVPELEYPTITRVWD 200
            ...::||   ..|||...:.......:|.|.....:...:...|..::|   |..::.:..:.|.
  Fly   153 CKAIAFRFSKEEPKEKPVKESIWEPMEEFRERRGEENVTKYLTRRFSMY---PFSKFISNNQAWA 214

  Fly   201 RFQGMFDGLSDALIYLPAFRAYHWQMLEELYNDNVMYTEIRTSFKTLYDASGRTFPRERTIHELY 265
            .|.|:|..|...|.:.|.:..|::..|:|...|.|.|.|:|:....||...|...    ||.:..
  Fly   215 HFMGIFILLDGLLCHAPIWAEYYYNALKEFAEDGVQYLELRSLLPPLYCIDGDML----TIRDTV 275

  Fly   266 ALN----QKFMKLHPDFLGFKVIMAVYRGYELDHLKDIVEVFKKLHQALPHFLVGFDLVGQEDKG 326
            |:.    ::|...||||:|.|:|.|..||.|...::..|:...:|::..|:|:|||||||||:.|
  Fly   276 AIYNSELERFRADHPDFIGSKLIYAPLRGVEPSVVEQYVKTAVELNKEFPNFMVGFDLVGQEELG 340

  Fly   327 KPLYSLLPVLRDLPPTARLFLHGGETNWFGASTDINLLDALLMNTTRIGHGYALAKHPILLNAVK 391
            :||...:..|..:|.....:.|.|||||||:..|.||:||:|:.|.|||||||:.|||:::...|
  Fly   341 RPLIDFVEPLLKMPEHINFYFHAGETNWFGSPIDENLVDAILLGTKRIGHGYAITKHPMMMRLAK 405

  Fly   392 SRRIAVELSPISNQVLHLVWDLRNHPGSQFFALDVPVVICNDDPGFWNAKGLSYDFYYAIMSLAP 456
            ...||:|:.|:|||||.|..|.||||.:...|.:||:||.:|||.||:...||:|||:|.:.:||
  Fly   406 LLGIAIEVCPVSNQVLQLGVDYRNHPAALLLAANVPIVISSDDPSFWHCAPLSHDFYFAFLGIAP 470

  Fly   457 NNAGLRLLKTLVWNSVRYSTLTEEEQTRAFKILELSWSRFIDDVLE 502
            ..|.||.||:|..||:|||.|..||:...::..:..|.::||||:|
  Fly   471 MKADLRFLKSLAINSIRYSALVGEEKRVGYRKWQEKWDKWIDDVVE 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Adgf-C	NP_650308.3	A_deaminase_N	5..98	CDD:285627	22/88 (25%)
		adm_rel	25..501	CDD:273620	172/482 (36%)
		ADGF	78..493	CDD:238646	156/421 (37%)
Adgf-B	NP_649006.2	A_deaminase_N	36..113	CDD:285627	20/78 (26%)
		adm_rel	56..515	CDD:273620	169/466 (36%)
		ADGF	93..507	CDD:238646	156/421 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469139
Domainoid	1	1.000	52	1.000	Domainoid score	I2828
eggNOG	1	0.900	-	-		E1_COG1816
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D197912at33208
OrthoFinder	1	1.000	-	-		FOG0003006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104612
Panther	1	1.100	-	-	P	PTHR11409
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.750