DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Adgf-C and Adgf-E

DIOPT Version :9

Sequence 1:	NP_650308.3	Gene:	Adgf-C / 41680	FlyBaseID:	FBgn0038173	Length:	506	Species:	Drosophila melanogaster
Sequence 2:	NP_610977.1	Gene:	Adgf-E / 36627	FlyBaseID:	FBgn0033952	Length:	539	Species:	Drosophila melanogaster

Alignment Length:	506	Identity:	166/506 - (32%)
Similarity:	263/506 - (51%)	Gaps:	21/506 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 MFVVLLTAQLQIQAQTALSYEQARQAVLTAEEELMTGGHTHLNTEEEKVDDIFMEYKLGELAQGF 70
            |.::.:.....::..|...|...|:...:.|.....|....|...|...:::.|..|..|..:|.
  Fly    33 MTLLEMLGTTNLRKSTPKDYRILREIFNSFERYSGVGNDIQLTLPERAANELIMCEKKREYEKGI 97

  Fly    71 RNAEQNAAALHFFKAKPLIDRSAIFRFLQKMPKGSVLHVHNTASVSSKWVVDDLSYMPGLLRCTT 135
            .:..:.|...|.|:....:.:|.:|:.|::||||:.|..|:|:..||: ||.:::|...|..|||
  Fly    98 MDPSKFAPGHHIFQVLTKVKKSPLFQILRRMPKGAALKAHDTSMCSSR-VVIEITYRDNLWVCTT 161

  Fly   136 ATGQSILSFR---RTPKEHKCQSQYVLVSDER-----RNSLDRQVYDRNFERLINL-YTPVPELE 191
            ..|..:..||   ..||:         ||.|.     ...|.....:.|..:.:.: ::..|...
  Fly   162 QNGCRVEEFRFAKDKPKD---------VSFENGEWQPMEKLRELRGEENLRKYLQMRFSMYPLAS 217

  Fly   192 YPTITRVWDRFQGMFDGLSDALI-YLPAFRAYHWQMLEELYNDNVMYTEIRTSFKTLYDASGRTF 255
            :.|....|....|:| ||.|.|: |.|.:..|::..|:|.|.|.|.|.|:|:....||...|...
  Fly   218 FTTNAHAWRHMMGIF-GLLDGLLQYAPVWGDYYYNALKEFYADGVQYLEVRSVLPQLYSLDGSRM 281

  Fly   256 PRERTIHELYALNQKFMKLHPDFLGFKVIMAVYRGYELDHLKDIVEVFKKLHQALPHFLVGFDLV 320
            |:..|:.......::|.|.||.|:..|:|.|..|..:.:.:.:.::...:|::..|.|:||||||
  Fly   282 PKRETVQIYKDTLERFKKEHPGFIDSKLIYAPIRHVQPELVGEYIKECTELNKEFPSFVVGFDLV 346

  Fly   321 GQEDKGKPLYSLLPVLRDLPPTARLFLHGGETNWFGASTDINLLDALLMNTTRIGHGYALAKHPI 385
            ||||.|.||.:....|..||.....:.|.|:|||:|:..|.|||||:::.|.||||||.:.|||:
  Fly   347 GQEDVGHPLSNFAAELLKLPDHIHFYFHAGQTNWYGSHVDQNLLDAIVLGTKRIGHGYTITKHPV 411

  Fly   386 LLNAVKSRRIAVELSPISNQVLHLVWDLRNHPGSQFFALDVPVVICNDDPGFWNAKGLSYDFYYA 450
            |:...|...||:|:.|:|||||.|..|.|:||.:...|.:||:||.:..||||.|..||:|||.|
  Fly   412 LMRLAKYLNIALEVCPVSNQVLQLGSDYRSHPAATLIAENVPMVIASGSPGFWRAAPLSHDFYMA 476

  Fly   451 IMSLAPNNAGLRLLKTLVWNSVRYSTLTEEEQTRAFKILELSWSRFIDDVL 501
            .:.:||.||.|:.||....||::||:|.:|.:..|.:..:..|.:::::::
  Fly   477 FLGIAPMNADLKFLKRTAKNSIKYSSLKDEAKAEAMEKWKKQWDKWVENIV 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Adgf-C	NP_650308.3	A_deaminase_N	5..98	CDD:285627	17/91 (19%)
		adm_rel	25..501	CDD:273620	164/485 (34%)
		ADGF	78..493	CDD:238646	152/424 (36%)
Adgf-E	NP_610977.1	A_deaminase_N	46..125	CDD:285627	16/78 (21%)
		adm_rel	52..527	CDD:273620	164/485 (34%)
		ADGF	105..519	CDD:238646	152/424 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469141
Domainoid	1	1.000	52	1.000	Domainoid score	I2828
eggNOG	1	0.900	-	-		E1_COG1816
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D197912at33208
OrthoFinder	1	1.000	-	-		FOG0003006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104612
Panther	1	1.100	-	-	P	PTHR11409
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	8	7.750