Protein Alignment Adgf-D and AMD1

DIOPT Version :10

• Sequence 1: NP_524345.2
• Gene: Adgf-D / 41679
• FlyBaseID: FBgn0038172
• Length: 502
• Species: Drosophila melanogaster
• Sequence 2: NP_013677.1
• Gene: AMD1 / 854973
• SGDID: S000004498
• Length: 810
• Species: Saccharomyces cerevisiae
• Alignment Length: 577
• Identity: 109/577 - (18%)
• Similarity: 184/577 - (31%)
• Gaps: 198/577 - (34%)

  Fly    32 EQIMEAERVASLGGNIWLSSDEEKANSILM-------NAKRAEIA---------------EGLKT 74
            :|::|       .|...|:.||..::|.::       |...:.||               .|.|.
Yeast    77 QQLLE-------NGTKQLALDEHDSHSAILEQPSHSTNCSSSNIAAMNKGHDSADHASQNSGGKP 134

  Fly    75 PEKYAPAMHF-------FQG----RQYVRQSEVFR--MIQKIPKGAFLHGHNTGMV--------- 117
            ....|.|.|.       |.|    .:.||.|..::  |:.......||...::.::
Yeast   135 RTLSASAQHILPETLKSFAGAPVVNKQVRTSASYKMGMLADDASQQFLDDPSSELIDLYSKVAEC 199

  Fly   118 -TSRWIIQNLTTTNNLYTCRNVDGLLVF------TYDQSGCHSEVQNV--CTERINAE--DRGKY 171
             ..|...|.::..|:....:|..|.:|:      :|     :|:.:.|  .|.:.:||  |..|.
Yeast   200 RNLRAKYQTISVQNDDQNPKNKPGWVVYPPPPKPSY-----NSDTKTVVPVTNKPDAEVFDFTKC 259

  Fly   172 ERQLEKHINMHGPRPEALLPNRKKIWERFENIFTTVDRLYKYRPTYCAYHKRMLEEL------CE 230
            |                 :|.....||     ||..|     ..:|..:.....:||      ..
Yeast   260 E-----------------IPGEDPDWE-----FTLND-----DDSYVVHRSGKTDELIAQIPTLR 297

  Fly   231 DNIIYAEIRASLS---PLYDDNNRTLSTLEVANELERIVEEF-------KAKHHDFIGVKVI--Y 283
            |..:..|...|:|   |......|.|..||....|..::.|:       :..|.||..|:.:  :
Yeast   298 DYYLDLEKMISISSDGPAKSFAYRRLQYLEARWNLYYLLNEYQETSVSKRNPHRDFYNVRKVDTH 362

  Fly   284 AKRNRASEEEMLRRITTFKQLHHAKPNFVI-------------------GFDL------------ 317
            ...:....::.|.|....| |.|:|...||                   |:||
Yeast   363 VHHSACMNQKHLLRFIKHK-LRHSKDEKVIFRDGKLLTLDEVFRSLHLTGYDLSIDTLDMHAHKD 426

  Fly   318 --------------IGQEDTGE---PLNRYI--NQLSDLPSTANYFFHAGETNWN---------G 354
                          ||:....|   ..|.||  ..|:|:  |....|....:.:.         |
Yeast   427 TFHRFDKFNLKYNPIGESRLREIFLKTNNYIKGTYLADI--TKQVIFDLENSKYQNCEYRISVYG 489

  Fly   355 RT--DWNMMDAILLNTKRIGHAFA-LPKHPQLWSTIKKRNIAIEVNPISNQVLGFVWDL----RN 412
            |:  :|:.:.:.:::.|.|.|... |.:.|:|:...||..|......|...:...::::    ::
Yeast   490 RSLDEWDKLASWVIDNKVISHNVRWLVQIPRLYDIYKKTGIVQSFQDICKNLFQPLFEVTKNPQS 554

  Fly   413 HPASFLIAENFPIVISSDD--------------PGVWGA---KGLSYDFYYAFMALA 452
            ||...:..:......|.||              |.:|.|   ...||..||.:..:|
Yeast   555 HPKLHVFLQRVIGFDSVDDESKVDRRFHRKYPKPSLWEAPQNPPYSYYLYYLYSNVA 611

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Adgf-D	NP_524345.2	A_deaminase_N	4..100	CDD:462481	20/102 (20%)
		ADGF	80..490	CDD:238646	96/507 (19%)
AMD1	NP_013677.1	AMP_deaminase	160..803	CDD:437158	92/487 (19%)