DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Adgf-D and Adgf-B

DIOPT Version :9

Sequence 1:	NP_524345.2	Gene:	Adgf-D / 41679	FlyBaseID:	FBgn0038172	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_649006.2	Gene:	Adgf-B / 39975	FlyBaseID:	FBgn0036751	Length:	520	Species:	Drosophila melanogaster

Alignment Length:	491	Identity:	192/491 - (39%)
Similarity:	284/491 - (57%)	Gaps:	26/491 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 YETLREQIMEAERVASLGGNIWLSSDEEKANSILMNAKRAEIAEGLKTPEKYAPAMHFFQGRQYV 91
            ::|||:.|.:...:..:|..|.|:..|..||.::|..|:.||::|:..|.::.|..|.|:....|
  Fly    40 FKTLRQAIAKVGHLNIMGQKIRLNDRELAANKVIMAVKKEEISKGILDPSQFTPGQHIFKTLAEV 104

  Fly    92 RQSEVFRMIQKIPKGAFLHGHNTGMVTSRWIIQNLTTTNNLYTCRNVDG--LLVFTYDQSGCHS- 153
            ::|.:|.:|:.:|||..||.|:|.:.::.::| :||...||:.|...:|  .:.|.:.:.....
  Fly   105 QKSPIFNLIKGMPKGGALHAHDTALCSTDYLI-SLTYRKNLWICTAEEGCKAIAFRFSKEEPKEK 168

  Fly   154 -------EVQNVCTERINAEDRGKYERQLEKHINMHGPRPEALLPNRKKIWERFENIFTTVDRLY 211
                   |......||...|:..||   |.:..:|:   |.:...:..:.|..|..||..:|.|.
  Fly   169 PVKESIWEPMEEFRERRGEENVTKY---LTRRFSMY---PFSKFISNNQAWAHFMGIFILLDGLL 227

  Fly   212 KYRPTYCAYHKRMLEELCEDNIIYAEIRASLSPLY--DDNNRTL-STLEVAN-ELERIVEEFKAK 272
            .:.|.:..|:...|:|..||.:.|.|:|:.|.|||  |.:..|: .|:.:.| ||||    |:|.
  Fly   228 CHAPIWAEYYYNALKEFAEDGVQYLELRSLLPPLYCIDGDMLTIRDTVAIYNSELER----FRAD 288

  Fly   273 HHDFIGVKVIYAKRNRASEEEMLRRITTFKQLHHAKPNFVIGFDLIGQEDTGEPLNRYINQLSDL 337
            |.||||.|:|||.........:.:.:.|..:|:...|||::||||:|||:.|.||..::..|..:
  Fly   289 HPDFIGSKLIYAPLRGVEPSVVEQYVKTAVELNKEFPNFMVGFDLVGQEELGRPLIDFVEPLLKM 353

  Fly   338 PSTANYFFHAGETNWNGR-TDWNMMDAILLNTKRIGHAFALPKHPQLWSTIKKRNIAIEVNPISN 401
            |...|::||||||||.|. .|.|::|||||.||||||.:|:.|||.:....|...|||||.|:||
  Fly   354 PEHINFYFHAGETNWFGSPIDENLVDAILLGTKRIGHGYAITKHPMMMRLAKLLGIAIEVCPVSN 418

  Fly   402 QVLGFVWDLRNHPASFLIAENFPIVISSDDPGVWGAKGLSYDFYYAFMALAPADADLRFLKQLAL 466
            |||....|.|||||:.|:|.|.|||||||||..|....||:|||:||:.:||..|||||||.||:
  Fly   419 QVLQLGVDYRNHPAALLLAANVPIVISSDDPSFWHCAPLSHDFYFAFLGIAPMKADLRFLKSLAI 483

  Fly   467 NSIKYAVLTSDERRKINRVFQRKWQEFIANVLNPKF 502
            |||:|:.|..:|:|...|.:|.||.::|.:|:..|:
  Fly   484 NSIRYSALVGEEKRVGYRKWQEKWDKWIDDVVEHKY 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Adgf-D	NP_524345.2	A_deaminase_N	4..100	CDD:285627	22/72 (31%)
		adm_rel	27..498	CDD:273620	190/485 (39%)
		ADGF	80..490	CDD:238646	171/424 (40%)
Adgf-B	NP_649006.2	A_deaminase_N	36..113	CDD:285627	22/72 (31%)
		adm_rel	56..515	CDD:273620	186/469 (40%)
		ADGF	93..507	CDD:238646	171/424 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45469135
Domainoid	1	1.000	52	1.000	Domainoid score	I2828
eggNOG	1	0.900	-	-		E1_COG1816
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D197912at33208
OrthoFinder	1	1.000	-	-		FOG0003006
OrthoInspector	1	1.000	-	-		otm48092
orthoMCL	1	0.900	-	-		OOG6_104612
Panther	1	1.100	-	-	P	PTHR11409
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R16839
SonicParanoid	0	0.000	Not matched by this tool.
	10	9.780