DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Adgf-D and ada2a

DIOPT Version :9

Sequence 1:	NP_524345.2	Gene:	Adgf-D / 41679	FlyBaseID:	FBgn0038172	Length:	502	Species:	Drosophila melanogaster
Sequence 2:	NP_001028889.2	Gene:	ada2a / 373884	ZFINID:	ZDB-GENE-030902-4	Length:	503	Species:	Danio rerio

Alignment Length:	506	Identity:	184/506 - (36%)
Similarity:	271/506 - (53%)	Gaps:	20/506 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAMWFLGALVATVVLLTGSVQATDLPYETLREQIMEAERVASLGGNIWLSSDEEKANSILMNAKR 65
            |.:.|||.|:...:||.........|....|:.::..|.....||:|.|:..|:..:..|...|:
Zfish     1 MHVLFLGDLMWIYLLLLCCASCNGRPDPRKRDALIGLEASRRTGGDITLNEREKLLDGKLQKLKQ 65

  Fly    66 AEIAEGLKTPEKYAPAMHFFQGRQYVRQSEVFRMIQKIPKGAFLHGHNTGMVTSRWIIQNLTTTN 130
            .::..|     ::.|:||||:.::.:.||.||.:|||:||||.||.|:..||:..|:::|:|...
Zfish    66 HDMEAG-----QFPPSMHFFKAKRLIDQSPVFNLIQKMPKGAALHVHDFAMVSVDWLVKNVTYRE 125

  Fly   131 NLYTCRNVDGLLVFTY------DQSGCHS-EVQNVCTERINAEDRGKYERQLEKHINMHGPRPEA 188
            |.|.|......:.|.:      ..|.|.| .:.....|:|  ::..:.:....:::.:....|:.
Zfish   126 NCYVCFTDKQTVQFIFSSGPPASSSHCSSWTLLRSLREKI--KNTTELDNSFIRNLTLFTEDPDR 188

  Fly   189 LLPNRKKIWERFENIFTTVDRLYKYRPTYCAYHKRMLEELCEDNIIYAEIRASLSPLYDDNNRTL 253
            ..||:..:|||||.:|.....|..|.|.:..|....|.:..||||:|.||||.|...|:.:.|..
Zfish   189 AYPNQDTVWERFEQVFLVAYGLVTYAPVFKDYLYEGLRQFYEDNIMYVEIRALLPQTYELDGRLN 253

  Fly   254 STLEVANELERIVEEFKAKHHDFIGVKVIYAKRNRASEEEMLRRITTFKQLHHAKPNFVIGFDLI 318
            .........:.:|.:||..|.||||.:||:....:.:..|.::.:.....|....|:.:.|||.:
Zfish   254 DKDWSMAACQEVVNQFKKHHPDFIGARVIFTVHRKINATEAVKTVEEAMILRRNFPDVMAGFDFV 318

  Fly   319 GQEDTGEPLNRYINQLSDLPSTAN----YFFHAGETNWNGR-TDWNMMDAILLNTKRIGHAFALP 378
            ||||.|.||..:.:.|| ||....    ||||||||:..|. .|.|:|||:|.||.||||.|||.
Zfish   319 GQEDLGRPLWYFKDALS-LPEDKGFNLPYFFHAGETDSQGTDVDQNLMDALLFNTTRIGHGFALA 382

  Fly   379 KHPQLWSTIKKRNIAIEVNPISNQVLGFVWDLRNHPASFLIAENFPIVISSDDPGVWGAKGLSYD 443
            :||.:....:|..:.|||.|||||||..|.|||:|||:.|:||..|:|||||||.|:||..||:|
Zfish   383 RHPVVKEMARKMYVPIEVCPISNQVLKLVSDLRDHPAAVLMAEGHPLVISSDDPAVFGATALSHD 447

  Fly   444 FYYAFMALAPADADLRFLKQLALNSIKYAVLTSDERRKINRVFQRKWQEFI 494
            ||.|||.......:|..||:|||||::|:.|:|..:.:.......||.:|:
Zfish   448 FYEAFMGFGGMSFNLGTLKELALNSLRYSTLSSQRKEEAIDALLVKWDKFV 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Adgf-D	NP_524345.2	A_deaminase_N	4..100	CDD:285627	26/95 (27%)
		adm_rel	27..498	CDD:273620	176/480 (37%)
		ADGF	80..490	CDD:238646	163/421 (39%)
ada2a	NP_001028889.2	A_deaminase_N	<29..95	CDD:285627	19/70 (27%)
		adm_rel	30..502	CDD:273620	176/477 (37%)
		ADGF	75..494	CDD:238646	163/421 (39%)
		Substrate binding. /evidence=ECO:0000250	197..204		5/6 (83%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595067
Domainoid	1	1.000	85	1.000	Domainoid score	I8137
eggNOG	1	0.900	-	-		E1_COG1816
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H81852
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56251
OrthoDB	1	1.010	-	-		D197912at33208
OrthoFinder	1	1.000	-	-		FOG0003006
OrthoInspector	1	1.000	-	-		mtm8425
orthoMCL	1	0.900	-	-		OOG6_104612
Panther	1	1.100	-	-	O	PTHR11409
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.720