Protein Alignment Adgf-D and AMPD3

DIOPT Version :10

• Sequence 1: NP_524345.2
• Gene: Adgf-D / 41679
• FlyBaseID: FBgn0038172
• Length: 502
• Species: Drosophila melanogaster
• Sequence 2: NP_000471.1
• Gene: AMPD3 / 272
• HGNCID: 470
• Length: 776
• Species: Homo sapiens
• Alignment Length: 507
• Identity: 99/507 - (19%)
• Similarity: 168/507 - (33%)
• Gaps: 188/507 - (37%)

  Fly    85 FQGRQYVRQSEVFRMIQKIPKGAFLHGHNTGMVTSRWIIQNLTTTNNLYTCRNVDGLLVF---TY 146
            |...:.:.:...|:.::..|...|.:            ::.:.|..:...|.|...||.|   ||
Human   294 FSLHEMLNEMSEFKELKSNPHRDFYN------------VRKVDTHIHAAACMNQKHLLRFIKHTY 346

  Fly   147 DQSGCHSEVQNVCTERINAEDRGK---------------YERQLEKHINMHGPRPEALLPNRKKI 196
            ...          .:|..||.||:               |:..::. :::|..|         :.
Human   347 QTE----------PDRTVAEKRGRKITLRQVFDGLHMDPYDLTVDS-LDVHAGR---------QT 391

  Fly   197 WERFENIFTTVDRLYKYRPTYCA----------------YHKRMLEELC----EDNIIYAEIRAS 241
            :.||:...:      ||.|...:                |..||::|:.    |....|:|.|.|
Human   392 FHRFDKFNS------KYNPVGASELRDLYLKTENYLGGEYFARMVKEVARELEESKYQYSEPRLS 450

  Fly   242 L---SP--------------LYDDNNRTLSTLEVANELERIVEEFKAKHHDFIGVKVI--YAKRN 287
            :   ||              :|..|.|.:.      ::.||.:.|::|       |::  :.|
Human   451 IYGRSPEEWPNLAYWFIQHKVYSPNMRWII------QVPRIYDIFRSK-------KLLPNFGK-- 500

  Fly   288 RASEEEMLRRI-------TTFKQLH---HAKPNFVIGFDLIGQED-----------------TGE 325
                  ||..|       |...|.|   |....:|.|||.:..|.                 |.|
Human   501 ------MLENIFLPLFKATINPQDHRELHLFLKYVTGFDSVDDESKHSDHMFSDKSPNPDVWTSE 559

  Fly   326 ---PLNRY----------INQLSDLPSTANYFF--HAGETNWNGRTDWNMMDAILLNTKRIGHAF 375
               |.:.|          :|.|......:.:.|  |.||..    :..:::.| .|....|.|..
Human   560 QNPPYSYYLYYMYANIMVLNNLRRERGLSTFLFRPHCGEAG----SITHLVSA-FLTADNISHGL 619

  Fly   376 ALPKHPQLWSTIKKRNIAIEVNPISNQVLGFVWDLRNHPASFLIAENFPIVISSDDPGVWGAKGL 440
            .|.|.|.|........|.|.::|:||..| |: :...:|....:.:...:.:|:|||
Human   620 LLKKSPVLQYLYYLAQIPIAMSPLSNNSL-FL-EYSKNPLREFLHKGLHVSLSTDDP-------- 674

  Fly   441 SYDFYYAFMALAP-----------ADADLRFLKQLALNSIKYAVLTSDERRK 481
             ..|:|...||..           :..|   |.::|.||:..:.|:..|::|
Human   675 -MQFHYTKEALMEEYAIAAQVWKLSTCD---LCEIARNSVLQSGLSHQEKQK 722

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Adgf-D	NP_524345.2	A_deaminase_N	4..100	CDD:462481	2/14 (14%)
		ADGF	80..490	CDD:238646	99/507 (20%)
AMPD3	NP_000471.1	AMP_deaminase	137..768	CDD:437158	99/507 (20%)